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Microtubule-Associated Proteins (Microtubule-Associated Protein 2)

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High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.

Also Known As:

Microtubule-Associated Protein 2; MAP1 Microtubule-Associated Protein; MAP2 Microtubule-Associated Protein; MAP3 Microtubule-Associated Protein; Microtubule Associated Proteins; Microtubule-Associated Protein 1; Microtubule-Associated Protein 3; MAP1 Microtubule Associated Protein; MAP2 Microtubule Associated Protein; MAP3 Microtubule Associated Protein; Microtubule Associated Protein 1; Microtubule Associated Protein 2; Microtubule Associated Protein 3; Microtubule-Associated Protein, MAP1; Microtubule-Associated Protein, MAP2; Microtubule-Associated Protein, MAP3

Networked: 382 relevant articles (5 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Cytoskeletal Proteins: 557
    - Microtubule Proteins: 31
      - Microtubule-Associated Proteins: 382
        tau Proteins: 2605
        Kinesin: 380
        Stathmin: 264
        Dynamins: 260
        dynactin: 79
        microtubule-associated protein 1B: 70
        MAP4: 34
        cytoplasmic linker protein 170: 27
        spindlin: 3
        cytoplasmic linker protein 115: 2
        doublecortin protein: 2
        rat Pde4dip protein: 2
        115 kDa epithelial microtubule-associate protein: 1
        kinesin-like protein 1: 1
        Arabidopsis AIR9 protein
        Arabidopsis APG8a protein
        Arabidopsis APG8i protein
        Arabidopsis CLASP protein
        Arabidopsis FRA1 protein
        Arabidopsis GCP1 protein
        Arabidopsis GCP2 protein
        Arabidopsis GCP3 protein
        Arabidopsis HINKEL protein
        Arabidopsis KIC protein
        Arabidopsis MAP18 protein
        Arabidopsis MAP65-1 protein
        Arabidopsis MAP65-5 protein
        Arabidopsis MAP65-6 protein
        Arabidopsis MAP70-5 protein
        Arabidopsis MOR1 protein
        Arabidopsis MPB2C protein
        Arabidopsis NEDD1 protein
        Arabidopsis POR protein
        Arabidopsis RIC1 protein
        Arabidopsis Spc98 protein
        Arabidopsis SPIRAL2 protein
        Arabidopsis SPR1 protein
        Arabidopsis TPX2 protein
        Artemia microtubule cross-linking protein
        axolinin
        C elegans adligin protein
        C elegans ELP-1 protein
        C elegans F53F4.3 protein
        C elegans Grip-1 protein
        C elegans KLP-15 protein
        C elegans KLP-16 protein
        C elegans KNL-1 protein
        C elegans KNL-2 protein
        C elegans KNL-3 protein
        C elegans lis-1 protein
        C elegans MKLP1 protein
        C elegans NDC-80 protein
        C elegans PTL-1 protein
        C elegans Rmd-1 protein
        C elegans SPD-1 protein
        Cercopithecus aethiops MBD-205 protein
        chartins
        chicken p22 calcium binding protein
        Chlamydomonas KHP1 protein
        Chlamydomonas PF20 protein
        Cricetulus griseus CdkI-p30 protein
        cytoplasmic linker protein 190
        Dictyostelium centrosomal protein 224-kDa
        Drosophila 205-kDa MAP protein
        Drosophila asp protein
        Drosophila cana protein
        Drosophila CENP-meta protein
        Drosophila CG10373 protein
        Drosophila CG33206 protein
        Drosophila chb protein
        Drosophila Cornetto protein
        Drosophila CP190 protein
        Drosophila Dgt6 protein
        Drosophila Feo protein
        Drosophila futsch protein
        Drosophila Glued protein
        Drosophila Grip128 protein
        Drosophila Grip163 protein
        Drosophila Grip71WD protein
        Drosophila Grip75 protein
        Drosophila Grip84 protein
        Drosophila huntingtin protein
        Drosophila Klp61F protein
        Drosophila KLP67A protein
        Drosophila Lava lamp protein
        Drosophila Lis-1 protein
        Drosophila Map60 protein
        Drosophila mini spindles protein
        Drosophila Msd1 protein
        Drosophila Ndc80 protein
        Drosophila patronin protein
        Drosophila Pavarotti protein
        Drosophila ROD protein
        Drosophila Spn-F protein
        Drosophila TACC protein
        Drosophila toucan protein
        EB1 microtubule binding proteins
        Emericella nidulans mipA protein
        fp3D2 protein
        human 76p protein
  - Nerve Tissue Proteins: 1
    - Microtubule-Associated Proteins: 382

Experts

1.	Abe, Koji: 4 articles (10/2014 - 04/2005)
2.	Yamashita, Toru: 3 articles (10/2014 - 11/2010)
3.	Deguchi, Kentaro: 3 articles (10/2014 - 11/2010)
4.	Kondo, Seiji: 3 articles (05/2008 - 09/2007)
5.	Kleinman, Joel E: 2 articles (09/2015 - 10/2004)
6.	Chen, Hong: 2 articles (08/2015 - 12/2011)
7.	Wang, Wei: 2 articles (03/2015 - 01/2013)
8.	Xiang, Yang: 2 articles (02/2015 - 07/2014)
9.	Hsu, Chin-Yuan: 2 articles (01/2015 - 02/2014)
10.	Li, Jing: 2 articles (01/2015 - 12/2013)

Related Diseases

1.	Ischemia 07/01/1994 - "Previous studies in gerbils have shown that cytoskeletal disruption and a loss of the dendritic microtubule-associated protein, MAP2, may occur after short periods of transient global ischemia. " 12/01/2005 - "The loss of neuronal immunoreactivity of the cytoskeletal microtubule-associated protein 2 (MAP2) is known to be a marker of--at least--transient functional failure of neurons following ischemia. " 01/01/1999 - "The microtubule-associated protein 2 immunoreactivity was completely lost before development of changes in nuclear morphology or DNA cleavage after complete ischemia. " 01/01/1999 - "In contrast, disappearance of the immunoreaction for microtubule-associated protein 2 was much faster than genomic DNA cleavage after unilateral hemispheric ischemia and reperfusion. " 01/01/1999 - "During evolution of delayed neuronal death after transient forebrain ischemia, loss of the immunoreaction for microtubule-associated protein 2 occurred almost in parallel with DNA cleavage in the CA1 region. "
2.	Anoxia (Hypoxia) 06/20/2014 - "Developmental study of the distribution of hypoxia-induced factor-1 alpha and microtubule-associated protein 2 in children's brainstem: comparison between controls and cases with signs of perinatal hypoxia." 02/01/2014 - "In hypoxia at rest, autophagic flux was increased, as indicated by an increased microtubule-associated protein 1 light chain 3 type II/I (LC3-II/I) ratio (+25%) and LC3-II expression (+60%) and decreased p62/SQSTM1 expression (-25%; P<0.05), whereas exercise reversed those changes to a level similar to that with normoxia except for p62/SQSTM1, which was further decreased (P<0.05). " 01/01/2014 - "We also found that protein levels of hypoxia-inducible factor-1α, BNIP3, Beclin and NDRG1 were increased and that enriched expression of BNIP3 and Beclin caused autophagy mediated by microtubule-associated protein 1 light chain 3 in the treated cells. " 07/14/2000 - "Cultures were then subjected to anoxia for 2 h and subsequently reincubated for 24 h prior to neuron immunostaining with microtubule-associated protein 2 (MAP-2) antibody. " 08/27/1993 - "To determine the effect of hypoxia on cytoskeletal structures and neuronal morphology, we performed experiments and examined anoxia-induced changes in microtubule-associated protein 2 (MAP2) and cell morphology in hippocampal slices in vitro. "
3.	Seizures (Seizure) 04/30/2003 - "We have carried out a chronological and comparative analysis of microtubule-associated protein 1A (MAP1A) and microtubule-associated protein 2 (MAP2) immunoreactivities in the hippocampi of seizure-resistant (SR) and seizure-sensitive (SS) gerbils. " 04/30/2003 - "Accumulation of microtubule-associated proteins in the hippocampal neurons of seizure-sensitive gerbils." 01/01/2003 - "It has been shown that modification of microtubule (MT) ultrastructure are accompanied by functional changes in microtubule-associated protein MAP2 in the hippocampus of Krushinsky--Molodkina rats (KM), which are prone to autogenic seizures. " 09/01/1995 - "Microtubule-associated protein 2 (MAP-2): a sensitive marker of seizure-related brain damage." 04/01/2004 - "We found that the overexpression of Arc as well as Arc induction by seizure in vivo decreased microtubule-associated protein 2 (MAP2) staining in the dendrites by immunocytochemistry, although MAP2 content was not changed on Western blot. "
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 07/13/2012 - "Multiple neurodegenerative disorders are linked to aberrant phosphorylation of microtubule-associated proteins (MAPs). " 07/11/2012 - "Furthermore, microtubule-associated proteins (MAPs) can block motor protein-powered transport in neurons, which can lead to neurodegenerative diseases. " 01/01/2011 - "Abnormal accumulation and aggregation of microtubule associated proteins (MAPs) plays an important role in the pathogenesis of neurodegenerative diseases. " 05/01/2005 - "Cytoskeletal components have been shown to play a major role in the maintenance of the nervous system through adulthood, and changes in neurofilaments and microtubule-associated proteins (MAPs) have been linked to a variety of neurodegenerative diseases. " 06/05/2015 - "To gain an improved understanding of the pathways regulating defective autophagy specifically in juvenile neuronal ceroid lipofuscinosis (JNCL or Batten disease), a neurodegenerative disease of childhood, we developed and piloted a GFP-microtubule-associated protein 1 light chain 3 (GFP-LC3) screening assay to identify, in an unbiased fashion, genotype-sensitive small molecule autophagy modifiers, employing a JNCL neuronal cell model bearing the most common disease mutation in CLN3. "
5.	Glioma (Gliomas) 06/01/2004 - "The authors found that recombinant wild-type VSV (rVSV-wt) rapidly eliminated C6 glioma cells from the coculture, but also caused significant damage to neurons, as measured by a loss of microtubule-associated protein 2 immunoreactivity and a failure in electrophysiological responses from neurons in the tissue slice. " 12/01/2014 - "In addition, we determined activation of autophagy in gliomas samples by assessing expression of microtubule-associated protein 1 light chain-3B (LC3B). " 06/01/2012 - "Here, we report that, shortly after infection, NDV triggers the formation of autophagosomes in U251 glioma cells, as demonstrated by an increased number of double-membrane vesicles, GFP-microtubule-associated protein 1 light chain 3 (GFP-LC3) a dot formations, and elevated production of LC3II. " 11/01/1993 - "Distinct mode of microtubule-associated protein 2 expression in the neuroblastoma/glioma cell line 108CC15/NG108-15." 12/01/2015 - "Transcriptional upregulation of microtubule-associated protein 2 is involved in the protein kinase A-induced decrease in the invasiveness of glioma cells."

Related Drugs and Biologics

1.	Hematoxylin (Haematoxylon)
2.	Eosine Yellowish-(YS) (Eosin)
3.	KB 5666
4.	HU 211 (HU 210)
5.	Tubulin
6.	Phosphotransferases (Kinase)
7.	Synaptophysin
8.	Glial Fibrillary Acidic Protein
9.	Cytoskeletal Proteins
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Transplantation (Transplant Recipients)
4.	Mesenchymal Stem Cell Transplantation
5.	Resuscitation