Microphthalmos

09/01/2005 - "The records of all patients with a phthisical globe or microphthalmos who underwent a corneal covering procedure to allow comfortable wearing of a cosmetic scleral shell between March 1999 and July 2004 were reviewed. "
03/01/2003 - "But the use of cosmetic scleral shells in all cases of microphthalmos, even severe ones, is useful and effective."
03/01/2003 - "One child presenting a bilateral microphthalmos received a cosmetic scleral shell with optical correction. "
09/01/2006 - "Children with congenital microphthalmos are usually able to wear an eye prosthesis but the cosmetic aspect is determined by the size of the orbital volume deficiency. "
01/01/2011 - "To describe the prevalence of congenital anophthalmia and microphthalmia in Hospital Universitario La Paz, and to identify associated risk factors and evaluate cosmetic results in treated and nontreated patients. "

07/01/2007 - "To evaluate the efficacy of ethanolamine oleate (EO) sclerotherapy in the management of orbitopalpebral cysts associated with congenital microphthalmos, and compare it with simple cyst aspiration. "
07/01/2007 - "Ethanolamine oleate sclerotherapy versus simple cyst aspiration in the management of orbitopalpebral cyst associated with congenital microphthalmos."
05/01/2005 - "Ethanolamine oleate sclerotherapy in the management of orbito-palpebral cyst associated with congenital microphthalmos."
05/01/2005 - "Ethanolamine oleate sclerotherapy may be an effective minimal intervention treatment option for cosmetic rehabilitation of patients with orbito-palpebral cyst associated with congenital microphthalmos with no visual potential."

10/01/1982 - "Study of the prenatal morphogenesis of the microphthalmia suggested that the primary disorder reflects a disturbance of the neuroepithelium of the retinal anlage and results in defective early formation of the optic cup. "
09/01/2015 - "In the eye primordium, Meis1 coordinates, in a dose-dependent manner, retinal proliferation and differentiation by regulating genes responsible for human microphthalmia and components of the Notch signaling pathway. "
11/01/2013 - "Retinal lamination and initial neurogenesis are not affected by RA exposure, but we found widespread apoptosis after RA treatment that could be the main cause of microphthalmia. "
11/01/2013 - "We did not find severe alterations in 0.1μM RA treated animals, but the exposure to 1μM RA significantly reduced retinal size upon treatment, and this microphthalmia persisted through larval development. "
11/01/2013 - "Perturbations in its levels cause retinal malformations such as microphthalmia. "

09/01/2011 - "These studies suggest that FASD intervention strategies based upon augmentation of RA or Shh signaling may not prevent ethanol-induced microphthalmia."
01/01/2014 - "Thermal preconditioning partially prevented ethanol-mediated microphthalmia while maintaining Hsf-1 expression. "
01/01/2014 - "We used the zebrafish model to elucidate eye-specific mechanisms that underlie ethanol-mediated microphthalmia (reduced eye size), through time-series microarray analysis of gene expression within eyes of embryos exposed to 1.5% ethanol. "
09/01/2011 - "Injection of 20% ethanol (125μl) directly into the yolk sac of HH-stage 7 embryos resulted in an overall 30% incidence of eye anomalies including microphthalmia. "
09/01/2011 - "The eye is a sensitive indicator of the teratogenic effects of ethanol with ophthalmic defects such as microphthalmia frequently observed in FAS children. "

10/01/2015 - "The microphthalmia (MiT) family of transcription factors is an important mediator of metabolism. "
06/01/2014 - "We examined the role of a key NR transcription factor, visual system homeobox 2 (VSX2), using hiPSCs derived from a patient with microphthalmia caused by an R200Q mutation in the VSX2 homeodomain region. "
01/01/2014 - "Microphthalmia is a severe ocular disorder, and this condition is typically caused by mutations in transcription factors that are involved in eye development. "
01/01/2012 - "This correlates with reduced and enhanced expression, respectively, of microphthalmia-associated (Mitf) and Pou3f2/Brn-2 transcription factors. "
08/01/2004 - "The mi (microphthalmia) locus of mice encodes a transcription factor, MITF. "

06/01/2012 - "Our present study observed the morphologic changes in conventional Msx2 knockout (KO) mice and found phenotypes consistent with Peters anomaly and microphthalmia seen in humans. "
11/01/2014 - "Ophthalmopathologic examination of the eyes revealed microphthalmia with anterior segment developmental anomalies, in particular sclerocornea and Peters' anomaly, respectively. "
11/01/2014 - "Analysis of 24 unrelated A/M exomes identified a novel c.2122G>A, p.(Gly708Arg) mutation in an additional patient with unilateral microphthalmia, bilateral microcornea and Peters anomaly; the mutation was absent in the unaffected mother and the unaffected father was not available. "
06/01/2008 - "Sox11-deficient mice show a persistent lens stalk, a delay in lens formation, and the phenotypes of Peters' anomaly and microphthalmia at birth. "
02/01/2003 - "Malformed fetuses displayed a range of ocular defects that included microphthalmia and keratolenticular dysgenesis (Peters anomaly). "

12/01/1974 - "[Electrophoretic study of the proteins of the cerebral cortex of mice with hereditary microphthalmia]."
05/01/2004 - "The novel mouse microphthalmia mutations Mitfmi-enu5 and Mitfmi-bcc2 produce dominant negative Mitf proteins."
10/11/1995 - "The TFE3 pro-rich activation domain contains regions of strong homology with the related proteins microphthalmia and TFEB, suggesting that these regions are important for function. "
01/01/2014 - "Therefore, we speculated that the microphthalmos/aphakia in this mutant is caused by the expression of truncated PITX3, resulting in the abnormal expression of downstream targets and lens fiber proteins. "
11/01/2007 - "The loss of both products of the CDKN2A gene, proteins p16(ARF) and p14(INK4a), or amplification of microphthalmia-associated transcriptional factor (MITF) are also predisposing factors in the development of melanoma. "

09/01/2012 - "Early retinoic acid deprivation in developing zebrafish results in microphthalmia."
06/01/1992 - "Some drugs, for instance retinoic acid are regulators of Hox genes which control an ordered sequence of differentiation; coloboma or microphthalmos may appear if deregulation occurs. "
10/03/2013 - "Our study thus suggests that both recessive and dominant mutations in RARB cause anophthalmia and/or microphthalmia and diaphragmatic hernia, providing further evidence of the crucial role of the retinoic acid pathway during eye development and organogenesis. "
10/01/2000 - "A wide spectrum of congenital abnormalities, including exophthalmos, microphthalmia and anophthalmia, maxillo-mandibular dysostosis, micrognathia of both maxilla and mandible, cleft palate, subdevelopment of ear lobe, preauricular tags and macroglossia, were observed in the offspring of retinoic acid treated animals. "
09/01/2011 - "Ethanol-induced microphthalmia is not mediated by changes in retinoic acid or sonic hedgehog signaling during retinal neurogenesis."

01/01/1999 - "High heterozygosity (0.81) makes this polymorphism a useful marker in the genetic study of disorders localized at the 14q32 region, such as autosomal recessive congenital microphthalmia (CMIC)."
10/10/2013 - "Congenital microphthalmia (CMIC) is a common developmental ocular disorder characterized by a small, and sometimes malformed, eye. "
05/01/1998 - "However, both CHX10 (14q24.3), mutations of which give rise to CMIC in mouse models, and OTX2 (14q21-22) can be excluded as candidates for autosomal recessive congenital microphthalmia (arCMIC), since they map outside the critical disease region defined by recombination events. "
05/01/1998 - "Congenital microphthalmia (CMIC) (OMIM 309700) may occur in isolation or in association with a variety of systemic malformations. "
10/10/2013 - "Posterior microphthalmia (PM) and nanophthalmia are two rare subtypes of isolated CMIC characterized by extreme hyperopia due to short axial length and elevated lens/eye volume ratio. "

11/01/2012 - "In our search for novel genes that cause autosomal recessive microphthalmia when mutated, we enrolled a family that consists of third-cousin parents and two children with isolated colobomatous microphthalmia. "
08/01/1989 - "The gene for microphthalmia in the homozygous cinnamon mouse produces colobomatous microphthalmia due to failure of closure of the optic fissure. "
01/01/2010 - "Seventy patients having non-syndromic forms of colobomatous microphthalmia (n=25), isolated microphthalmia (n=18), or anophthalmia (n=17), and syndromic forms of micro/anophthalmia (n=10) were included in this study after negative molecular screening for OTX2, RAX, SOX2, and CHX10 mutations. "

09/01/2006 - "Children with aphakia (17), coloboma (5), refractive error (5) and microphthalmos (4) benefited from spectacles. "
04/01/2000 - "The aim of the study was (1) to determine the need for spectacles in children in Southern India with coloboma, microphthalmos and microcornea, (2) to describe their refractive errors and (3) to assess their needs for low vision aids (LVAs). "

07/01/2007 - "To evaluate the efficacy of ethanolamine oleate (EO) sclerotherapy in the management of orbitopalpebral cysts associated with congenital microphthalmos, and compare it with simple cyst aspiration. "
07/01/2007 - "Ethanolamine oleate sclerotherapy versus simple cyst aspiration in the management of orbitopalpebral cyst associated with congenital microphthalmos."
05/01/2005 - "Ethanolamine oleate sclerotherapy in the management of orbito-palpebral cyst associated with congenital microphthalmos."
11/01/2015 - "Percutaneous Ethanolamine Sclerotherapy of a Retrobulbar Cyst in a Child with Microphthalmos and Proptosis."
05/01/2005 - "Ethanolamine oleate sclerotherapy may be an effective minimal intervention treatment option for cosmetic rehabilitation of patients with orbito-palpebral cyst associated with congenital microphthalmos with no visual potential."

01/01/2013 - "We considered the PPL and 25 gauge vitrectomy effective in microphthalmos when performed safely."
01/01/2013 - "We report the first case report of pars plana lensectomy (PPL) and pars plana vitrectomy using a 25 gauge vitrectomy system for microphthalmos. "
01/01/2014 - "Acquired retinoschisis resolved after 23Gage pars plana vitrectomy in posterior microphthalmos."
01/01/2013 - "A case of 25 gauge vitrectomy for malignant glaucoma with microphthalmos."

06/01/2014 - "Surgical management of extensive epibulbar choristoma associated with microphthalmos using a simplified method of partial tumor excision and skin grafting can result in improved cosmetic outcomes."

10/01/2006 - "Ocular defects including microphthalmia and uveal coloboma, which have previously been shown to result from ethanol administered by gavage or via intraperitoneal injection on these days, served as the developmental end point for this study. "