Metolazone (Diulo)

A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic RENAL FAILURE. It also tends to lower BLOOD PRESSURE and increase POTASSIUM loss.

Also Known As:

Networked: 75 relevant articles (8 outcomes, 4 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Ng, Tien M H: 2 articles (07/2013 - 11/2012)
2.	Rich, Jonathan D: 1 article (04/2015)
3.	Hogg, Jennifer: 1 article (04/2015)
4.	Choi, Suji: 1 article (04/2015)
5.	Moranville, Michael P: 1 article (04/2015)
6.	Anderson, Allen S: 1 article (04/2015)
7.	Schulte, Phillip J: 1 article (11/2014)
8.	Heizer, Gretchen: 1 article (11/2014)
9.	Dickstein, Kenneth: 1 article (11/2014)
10.	Patel, Priyesh A: 1 article (11/2014)

Related Diseases

1.	Hypertension (High Blood Pressure) 01/01/1986 - "We conclude that 0.5 mg of metolazone is safe and effective therapy for hypertension; it will significantly reduce systolic and diastolic blood pressure and minimizes changes in laboratory test values." 05/01/1978 - "Metolazone for effective treatment of hypertension." 01/01/1986 - "Two multicenter, double-blind, randomized studies were performed to determine the antihypertensive efficacy and effects on laboratory values of a new, shorter-acting formulation of metolazone in patients with mild to moderate hypertension. " 01/01/1986 - "Clinical studies of a new, low-dose formulation of metolazone for the treatment of hypertension." 12/18/1979 - "[Treatment of hypertension with metolazone in general practice - a joint study (author's transl)]."
2.	Heart Failure 09/01/2014 - "Metolazone, since its introduction in 1970s, has been proven effective in managing refractory heart failure, but whether its potential effect could be applied in ESRF patients not receiving dialysis is awaited to be proven. " 01/06/1990 - "17 patients with New York Heart Association (NYHA) class IV congestive cardiac failure, refractory to conventional treatment, were additionally treated with oral metolazone (1.25-10 mg daily). " 01/06/1990 - "Metolazone in treatment of severe refractory congestive cardiac failure." 08/01/2005 - "Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature." 04/01/2015 - "Comparison of metolazone versus chlorothiazide in acute decompensated heart failure with diuretic resistance."
3.	Edema 01/01/1974 - "Efficacy of metolazone in patients with renal edema." 03/01/2003 - "Metolazone and its role in edema management." 07/01/1973 - "Use of a new diuretic agent (metolazone) in patients with edema and ascites." 11/01/1984 - "Efficacy of metolazone and furosemide in children with furosemide-resistant edema." 01/01/1990 - "A combination of metolazone (0.2 mg/kg/day) and furosemide (4 mg/kg/day) was used in the treatment of a 2-week-old neonate who developed severe edema after cardiac surgery. "
4.	Lung Diseases (Lung Disease) 04/25/1997 - "These findings suggest that in infants with chronic lung disease, diuretic therapy induces intercompartmental shifts in body water, ultimately decreasing interstitial water while preserving PV. Only combined treatment with furosemide plus metolazone produced a significant increase in urine output, confirming the increased efficacy of combination therapy in inducing diuresis."
5.	Cough 03/01/1997 - "Cough frequency evaluated by the visual analog scale was significantly lower for losartan than for lisinopril and similar to that for metolazone. " 03/01/1997 - "The incidence of cough with losartan (18%) was significantly lower than with lisinopril (97%) and similar to that for metolazone (21%). " 03/01/1997 - "Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough." 03/01/1997 - "This study compared the incidence of cough with the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the diuretic metolazone with angiotensin II receptor antagonist losartan in elderly hypertensive patients with previous histories of ACE inhibitor-induced cough. "

Related Drugs and Biologics

1.	Furosemide (Lasix)
2.	Metolazone (Diulo)
3.	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)
4.	Bendroflumethiazide (Naturetin)
5.	Reserpine (Serpasil)
6.	Losartan (Cozaar)
7.	Lisinopril (Prinivil)
8.	Angiotensin Receptors (Angiotensin II Receptor)
9.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
10.	Diuretics

Related Therapies and Procedures

1.	Palliative Care (Palliative Medicine)
2.	Intravenous Infusions
3.	Renal Dialysis (Hemodialysis)
4.	Drug Therapy (Chemotherapy)
5.	Aftercare (After-Treatment)