Metolazone (Diulo)

09/01/2014 - "Metolazone, since its introduction in 1970s, has been proven effective in managing refractory heart failure, but whether its potential effect could be applied in ESRF patients not receiving dialysis is awaited to be proven. "
01/06/1990 - "17 patients with New York Heart Association (NYHA) class IV congestive cardiac failure, refractory to conventional treatment, were additionally treated with oral metolazone (1.25-10 mg daily). "
01/06/1990 - "Metolazone in treatment of severe refractory congestive cardiac failure."
11/01/1975 - "Biochemical and clinical effects of metolazone in congestive heart failure."
01/01/2016 - "Efficacy of Intravenous Chlorothiazide for Refractory Acute Decompensated Heart Failure Unresponsive to Adjunct Metolazone."

05/01/1978 - "Metolazone for effective treatment of hypertension."
01/01/1986 - "Clinical studies of a new, low-dose formulation of metolazone for the treatment of hypertension."
12/18/1979 - "[Treatment of hypertension with metolazone in general practice - a joint study (author's transl)]."
12/01/1978 - "[Metolazone in arterial hypertension. "
10/27/1978 - "Metolazone for hypertension?"

01/01/1974 - "Efficacy of metolazone in patients with renal edema."
03/01/2003 - "Metolazone and its role in edema management."
11/01/1984 - "Efficacy of metolazone and furosemide in children with furosemide-resistant edema."
01/01/1990 - "A combination of metolazone (0.2 mg/kg/day) and furosemide (4 mg/kg/day) was used in the treatment of a 2-week-old neonate who developed severe edema after cardiac surgery. "
01/01/1990 - "Combination of metolazone and furosemide in the treatment of edema in the first month of life."

12/01/1976 - "Effects of prolonged administration of metolazone in the treatment of essential hypertension."
08/01/1974 - "The effects of metolazone in the long-term treatment of essential hypertension."
04/01/1977 - "Renin angiotensin system parameters and blood pressure (B.P.) were followed monthly in patients with essential hypertension on metolazone, 5 mg daily for three months and with added propranolol, 40 to 160 mg, for the subsequent three months. "
10/01/1975 - "Metolazone in essential hypertension: the long-term clinical efficacy of a new diuretic."
01/01/1974 - "[Electrolyte balance, plasma renin concentration and reaction of blood pressure in patients with essential hypertension and control subjects during therapy with metolazone, a new diuretic]."

04/25/1997 - "These findings suggest that in infants with chronic lung disease, diuretic therapy induces intercompartmental shifts in body water, ultimately decreasing interstitial water while preserving PV. Only combined treatment with furosemide plus metolazone produced a significant increase in urine output, confirming the increased efficacy of combination therapy in inducing diuresis."