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Metiamide

A histamine H2 receptor antagonist that is used as an anti-ulcer agent.

Also Known As:

Metiamide Monohydrochloride; SK&F-92058; SKF-92058; Monohydrochloride, Metiamide; SK&F 92058; SK&F92058; SKF 92058; SKF92058; Thiourea, N-methyl-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-

Networked: 79 relevant articles (4 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 58
- Urea: 9142
  - Thiourea: 242
    - Metiamide: 79
      - SK&F 91581
- Sulfur Compounds: 135
  - Thiourea: 242
    - Metiamide: 79
      - SK&F 91581

Related Diseases

1.	Ulcer 12/15/1977 - "In contrast, with restraint and metiamide, ulcer index was not improved, whereas mucosal blood flow was restored to almost control levels. " 01/01/1983 - "Anti-ulcer effect of metiamide was stronger than its antisecretory action, suggesting also the antiulcer action of metiamide other than inhibition of acid secretion. " 06/01/1977 - "This paper presents the results of a pilot study to investigate whether the administration of a nocturnal dose of metiamide (the first orally active H2 receptor antagonist) would prevent or delay the relapse of duodenal ulceration after initial ulcer healing. " 04/01/1977 - "During stress the ulcer incidence is high, lower with prophylactic administration of metiamide and least with the latter and preserved gastroduodenal acid transit. " 04/01/1977 - "[Evaluation of H2 receptor blockade with metiamide in stress ulcers in rats]."
2.	Gastritis 05/01/1977 - "Metiamide and cimetidine were effective in preventing this type of experimental acute erosive gastritis." 04/01/1977 - "Aspirin- and bile- induced acute erosive gastritis: its prevention by metiamide therapy." 02/01/1977 - "Capsaicin induced acute erosive gastritis: its prevention by antacid, metiamide and cimetidine." 05/01/1977 - "Acute erosive gastritis induced by aspirin, ketoprofen, ibuprofen, and naproxen: its prevention by metiamide and cimetidine."
3.	Vomiting 06/01/1976 - "1 The protective effects of the intracerebroventicular (i.c.v.) administration of the H1-receptor antagonist, mepyramine and the H2-receptor antagonists, burimamide and metiamide on centrally induced histamine-emesis were studied in unanaesthetized dogs. " 01/01/1989 - "Intraventricular pretreatment with opioid antagonist naloxone, histamine H1 antagonist mepyramine and H2 antagonists metiamide and cimetidine afforded protection to icv morphine emesis. "
4.	Duodenal Ulcer (Curling's Ulcer) 06/17/1976 - "Recent clinical trials have shown Metiamide to be superior to placebo in therapy of duodenal ulcer." 06/01/1977 - "Endoscopically confirmed duodenal ulcer relapses occurred in two out of eight on metiamide and six out of eight on placebo. " 08/01/1976 - "In duodenal ulcer patients the peak concentration is sustained throughout the 3 hour test period, and this response is not affected by the administration of Metiamide. " 05/01/1976 - "Letter: Metiamide in duodenal ulcer." 08/22/1974 - "Metiamide, an H2-receptor blocker, as inhibitor of basal and meal-stimulated gastric acid secretion in patients with duodenal ulcer."
5.	Zollinger-Ellison Syndrome (Syndrome, Zollinger-Ellison) 02/01/1977 - "The increased fractional rate of gastric emptying in patients with Zollinger-Ellison syndrome persisted despite abolition of gastric hypersecretion by metiamide. " 01/01/1977 - "Five patients with Zollinger-Ellison syndrome received metiamide per os in doses ranging from 600 to 1,200 mg/day for a minimum period of 2 weeks. " 01/01/1977 - "Metiamide treatment in five patients with Zollinger-Ellison syndrome." 05/01/1975 - "Proceedings: Metiamide therapy in the Zollinger-Ellison syndrome." 03/01/1975 - "Inhibition of gastric acid secretion by metiamide in Zollinger-Ellison syndrome."

Related Drugs and Biologics

1.	Cimetidine (Biomet)
2.	Histamine (Histamine Dihydrochloride)
3.	Pyrilamine (Mepyramine)
4.	Burimamide
5.	Atropine (Hyoscyamine)
6.	Aspirin (Acetylsalicylic Acid)
7.	Pepsin A (Pepsin)
8.	Histamine Receptors (Histamine Receptor)
9.	Ranitidine (Zantac)
10.	Indomethacin (Indometacin)

Related Therapies and Procedures

1.	Parathyroidectomy
2.	Vagotomy
3.	Chemical Sympathectomy
4.	Intravenous Infusions
5.	Renal Dialysis (Hemodialysis)