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Methylthiouracil

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A thiourea antithyroid agent that inhibits the synthesis of thyroid hormone. It is used in the treatment of hyperthyroidism.

Also Known As:

4-Methyl-2-thiouracil; Alkiron; Metacil; Physicians Brand of Methylthiouracil; Thimecil; 4(1H)-Pyrimidinone, 2,3-dihydro-6-methyl-2-thioxo-

Networked: 154 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 319
    - Pyrimidinones: 14
      - Uracil: 1106
        Thiouracil: 406
        Methylthiouracil: 154

Experts

1.	Lee, Hyun-Shik: 1 article (09/2015)
2.	Jung, Byeongjin: 1 article (09/2015)
3.	Bae, Jong-Sup: 1 article (09/2015)
4.	Kang, Hyejin: 1 article (09/2015)
5.	Baek, Moon-Chang: 1 article (09/2015)
6.	Stempniak, B: 1 article (09/2009)
7.	Bartel, H: 1 article (09/2009)
8.	Slotwinska, D: 1 article (09/2009)
9.	Dabrowski, R: 1 article (09/2009)
10.	Zukowska, D: 1 article (09/2009)

Related Diseases

1.	Graves Disease (Basedow Disease) 06/01/1960 - "Effect of methylthiouracil and iodide on the iodinated constituents of thyroid tissue in Graves' disease." 03/31/1952 - "[Remote results of methylthiouracil therapy of Basedow's disease]." 03/01/1950 - "[Effects of methylthiouracil and aminothiazole in preoperative therapy in Basedow's disease and thyreotoxicosis]." 04/01/1950 - "[Relapse of Basedow's disease, with grave symptoms of cardiac insufficiency, following subtotal thyroidectomy, cured by methylthiouracil]." 01/01/1954 - "[Subacute miliary tuberculosis in Graves-Basedow disease treated with methylthiouracil]."
2.	Pheochromocytoma 07/06/1946 - "The clinical picture and treatment of pheochromocytomas of the suprarenal; two own cases, one with paroxysmal hypertension improved by treatment with methylthiouracil and cured by surgical intervention."
3.	Hypertension (High Blood Pressure) 07/06/1946 - "The clinical picture and treatment of pheochromocytomas of the suprarenal; two own cases, one with paroxysmal hypertension improved by treatment with methylthiouracil and cured by surgical intervention."
4.	Goiter 09/01/1949 - "[Experimental study of the thyroid: effect of tilia leaf extract on the methylthiouracil-induced goiter in the guinea-pig]." 09/01/1968 - "[Effect of methylthiouracil on the early course of the postoperative period in patients with nodular toxic goiter]." 05/01/1966 - "[The effects of local destruction of the reticular formation on development of goiter in rabbits in response to the methylthiouracil administration]." 01/01/1951 - "[Surgical results in goiters unsuccessfully treated with methylthiouracil]." 01/01/1951 - "[Mechanism of action of substances which inhibit methylthiouracil goiter]."
5.	Hyperthyroidism 06/01/1952 - "Therapeutic studies in hyperthyroidism: methylthiouracil." 01/01/1961 - "[Behavior of the reactivity of the organism in patients with hyperthyroidism treated with methylthiouracil]." 09/10/1955 - "[Combined methylthiouracil and x-ray treatment in hyperthyroidism]." 02/14/1955 - "[Therapy of primary diabetes complicated by low degree hyperthyroidism, with methylthiouracil]." 11/05/1952 - "[Experiences with methylthiouracil therapy of hyperthyroidism]."

Related Drugs and Biologics

1.	Iodine
2.	Butylated Hydroxytoluene (BHT)
3.	Thiouracil
4.	Thyroxine (Levothyroxine)
5.	Thyroid Hormones
6.	Methylnitrosourea (N-Methyl-N-nitrosourea)
7.	Diiodotyrosine
8.	Cystine (L-Cystine)
9.	Carbimazole
10.	Thyroglobulin

Related Therapies and Procedures

1.	Thyroidectomy
2.	Sympathectomy (Sympathectomies)
3.	Hypophysectomy
4.	Aftercare (After-Treatment)