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Methylmalonyl-CoA Mutase

An enzyme that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carbonyl group. It requires a cobamide coenzyme. A block in this enzymatic conversion leads to the metabolic disease, methylmalonic aciduria. EC 5.4.99.2.
Also Known As:
Isomerase, Methylmalonyl-CoA; Methylmalonyl CoA Isomerase; Methylmalonyl CoA Mutase; Mutase, Methylmalonyl-CoA; Methylmalonyl-CoA Isomerase; (R)-2-Methyl-3-oxopropanoyl-CoA CoA-carbonylmutase
Networked: 180 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Venditti, Charles P: 19 articles (01/2022 - 09/2006)
2. Chandler, Randy J: 16 articles (12/2021 - 09/2006)
3. Baumgartner, Matthias R: 9 articles (01/2021 - 08/2007)
4. Forny, Patrick: 6 articles (04/2020 - 01/2016)
5. Sloan, Jennifer L: 6 articles (01/2020 - 08/2013)
6. Rosenblatt, David S: 5 articles (01/2022 - 01/2006)
7. Hoffmann, Victoria: 5 articles (01/2021 - 04/2009)
8. Kölker, Stefan: 5 articles (01/2021 - 08/2007)
9. Peters, Heidi L: 5 articles (01/2016 - 11/2002)
10. Venturoni, Leah E: 4 articles (01/2022 - 01/2021)

Related Diseases

1. Methylmalonic acidemia
2. Bovine Tuberculosis
3. Ischemia
4. Metabolic Diseases (Metabolic Disease)
5. Inborn Errors Metabolism (Inborn Errors of Metabolism)

Related Drugs and Biologics

1. Enzymes
2. Methylmalonic Acid
3. Propionates
4. Neurotoxins
5. Vitamin B 12 (Cyanocobalamin)
6. cobamamide (adenosylcobalamin)
7. 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)
8. Acids
9. Vitamins
10. Coenzymes (Enzyme Cofactors)

Related Therapies and Procedures

1. Liver Transplantation
2. Therapeutics
3. Catheters
4. Punctures