Methylene Blue (Methylthioninium Chloride)

A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.

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Networked: 1670 relevant articles (99 outcomes, 208 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Müller, Olaf: 14 articles (03/2015 - 01/2003)
2.	Coulibaly, Boubacar: 11 articles (03/2015 - 01/2003)
3.	Walter-Sack, Ingeborg: 11 articles (04/2013 - 12/2004)
4.	Mansmann, Ulrich: 10 articles (04/2013 - 01/2005)
5.	Schirmer, R Heiner: 9 articles (03/2015 - 01/2003)
6.	Evora, Paulo Roberto Barbosa: 9 articles (01/2015 - 10/2006)
7.	Burhenne, Jürgen: 8 articles (06/2010 - 12/2004)
8.	Wiklund, Lars: 7 articles (10/2015 - 11/2006)
9.	Mockenhaupt, Frank P: 7 articles (03/2015 - 11/2005)
10.	Yaroslavsky, Anna N: 7 articles (09/2014 - 08/2003)

Related Diseases

1.	Methemoglobinemia 03/01/2008 - "The mean levels of MetHb in Gr II was statistically significant after 12, 24, 36, 48 and 72 hrs of methylene blue therapy as compared to Gr I. Continuous I.V methylene blue therapy causes significant decline in MetHb level and is more effective in treatment of methemoglobinemia as compared to intermittent regimen." 10/01/1988 - "Administration of methylene blue was effective in the reversal of the methemoglobinemia. " 02/01/2015 - "Currently, methylene blue is the drug of choice for the management of methemoglobinemia. " 10/31/2014 - "Here, we tested whether the experimental agent methylene blue (MB), used for treatment of methemoglobinemia, might improve AD-like pathology and behavioral deficits. " 09/01/2014 - "Methylene blue (MB) is used for various clinical purposes, including chromoendoscopy and methemoglobinemia treatment. "
2.	Neoplasms (Cancer) 01/01/2014 - "To study the accuracy and feasibility of identifying sentinel lymph nodes (SLN) using methylene blue dye in patients with cervical cancer. " 09/01/2004 - "This study was to investigate influential factors of identifying SLN with methylene blue in cervical cancer. " 11/01/2002 - "We used methylene blue dye to identify SN in patients with clinically non-palpable breast mass and palpable breast mass smaller than 3 cm. We also explored the role of imprint cytology and immunochemical studies to identify metastatic cancer cells in the lymph nodes. " 01/01/2016 - "Intravital staining with methylene blue in parotidectomies simplifies the operation and could assist in better visualization that leads to (1) rapid and precise localization of the tumor, (2) preservation of the facial nerve, and (3) complete removal of the gland tissue in cases with malignancy. " 12/01/2015 - "The patients with deep-lobe benign tumors were operated on with the method of superficial lobe preservation, which included methylene blue staining of the gland and intra-operative facial nerve detection. "
3.	Breast Neoplasms (Breast Cancer) 10/01/2007 - "This study was to evaluate the efficacy of methylene blue dye (MBD) as a tracer in SLNB for breast cancer, and to analyze its influencing factors. " 07/01/2011 - "We prospectively compare the efficacy of SLN biopsy and the number of SLNs identified, by injecting methylene blue (MB) alone in the subareolar area (SA) or peritumorally (PT) in patients with early stage breast cancer. " 10/01/2009 - "The aim of this prospective study was to analyze the safety of methylene blue dye (MBD) and compare its efficacy with that of isotopic mapping for sentinel lymph node (SLN) identification in breast cancer. " 08/01/2008 - "We aimed to evaluate the safety and efficacy of methylene blue dye (MBD) for sentinel lymph node (SLN) mapping in breast cancer. " 09/01/2004 - "Efficacy of methylene blue dye in localization of sentinel lymph node in breast cancer patients."
4.	Cyanosis 06/01/2010 - "After a single dose of methylene blue (1 mg/kg/dose), cyanosis was reduced and oxygenation improved. " 04/01/1989 - "Cyanosis was cleared and O2 saturation and PaO2 were normalized 15 mn after methylene blue (1 mg/kg) administered intravenously. " 04/01/1989 - "Pulse oximeters currently available are not helpful in patients treated with methylene blue and should be used with caution in patients who present with cyanosis of unknown origin." 01/01/1981 - "Methylene blue again cleared the cyanosis. " 11/01/2014 - "Methylene blue was administered and the patient promptly responded with resolution of cyanosis. "
5.	Malaria 06/01/2010 - "To assess the efficacy of methylene blue (MB) monotherapy in semi-immune adults with uncomplicated malaria in Burkina Faso. " 01/01/2009 - "We here report on the effects of methylene blue (MB)-based malaria combination therapy on gametocytaemia during a randomised-controlled trial in Burkina Faso. " 03/01/2008 - "Selective and sensitive methods for the determination of the cationic dye and anti-malarial methylene blue in human liquid whole blood, dried whole blood (paper spot), and plasma depending on protein precipitation and cation exchange chromatography coupled to electrospray ionisation (ESI) tandem mass spectrometry (MS/MS) have been developed, validated according to FDA standards, and applied to samples of healthy individuals and malaria patients within clinical studies. " 01/01/2008 - "Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have been promising with regard to its revival in malaria therapy. " 01/01/2015 - "Our data support further efforts to employ methylene blue as a safe, low-cost antimalarial to treat drug-resistant malaria."

Related Drugs and Biologics

1.	Guanylate Cyclase (Guanylyl Cyclase)
2.	artesunate
3.	Nitric Oxide (Nitrogen Monoxide)
4.	1-phenyl-3,3-dimethyltriazene (PDT)
5.	Doxorubicin (Adriamycin)
6.	Nitric Oxide Synthase (NO Synthase)
7.	NG-Nitroarginine Methyl Ester (L-NAME)
8.	Methemoglobin
9.	Heparin (Liquaemin)
10.	Hemoglobin M

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Catheters
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Thyroidectomy
5.	Anesthesia