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Methoxamine (Methoxamine Hydrochloride)

Subscribe to New Research on Methoxamine

An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.

Also Known As:

Methoxamine Hydrochloride; Vasoxyl; Glaxo Wellcome Brand 1 of Methoxamine Hydrochloride; Glaxo Wellcome Brand 2 of Methoxamine Hydrochloride; Metoxamine Wellcome; Vasoxin; Vasoxine; Vasylox; Wellcome Brand of Methoxamine Hydrochloride; Hydrochloride, Methoxamine; Wellcome, Metoxamine; Methoxamedrin; Benzenemethanol, alpha-(1-aminoethyl)-2,5-dimethoxy-

Networked: 279 relevant articles (13 outcomes, 22 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Amino Alcohols: 14
    - Propanolamines: 3
      - Methoxamine: 279
        isopropylmethoxamine: 1
  - Ethylamines: 5
    - Phenethylamines: 14
      - Methoxamine: 279
        isopropylmethoxamine: 1
- Alcohols: 387
  - Amino Alcohols: 14
    - Propanolamines: 3
      - Methoxamine: 279
        isopropylmethoxamine: 1
  - Propanols: 2
    - Propanolamines: 3
      - Methoxamine: 279
        isopropylmethoxamine: 1

Experts

1.	Carlsson, Leif: 4 articles (01/2011 - 08/2005)
2.	Kumar, Velayudhan Mohan: 3 articles (08/2006 - 01/2003)
3.	Mallick, Hruda Nanda: 3 articles (08/2006 - 01/2003)
4.	Duker, G: 2 articles (01/2012 - 02/2001)
5.	Duker, Göran: 2 articles (01/2011 - 10/2008)
6.	Loureiro-Silva, Mauricio R: 2 articles (11/2008 - 04/2003)
7.	Groszmann, Roberto J: 2 articles (11/2008 - 04/2003)
8.	Nattel, Stanley: 2 articles (10/2008 - 07/2008)
9.	Vetrivelan, Ramalingam: 2 articles (08/2006 - 04/2006)
10.	Carlsson, L: 2 articles (07/2001 - 02/2001)

Related Diseases

1.	Heart Arrest (Cardiac Arrest) 11/01/2001 - "An intravenous alpha agonist, such as methoxamine 20 mg, should be considered for any case of cardiac arrest secondary to electromechanical dissociation which is unresponsive to epinephrine given according to current guidelines." 08/01/1995 - "A randomized, double-blind comparison of methoxamine and epinephrine in human cardiopulmonary arrest." 07/01/1987 - "Methoxamine, a pure alpha-1 agonist, has only been shown to be comparable to epinephrine in restoring circulation after cardiac arrest in a canine model. " 08/01/1995 - "This study failed to demonstrate any difference in the rate of initial resuscitation, survival to discharge from the hospital, or neurologic status with methoxamine as opposed to epinephrine in the setting of cardiac arrest." 07/01/1987 - "This study compares the effectiveness of equipotent doses of epinephrine and methoxamine in improving CBF during CPR after a prolonged cardiac arrest in a swine model. "
2.	Hypotension (Low Blood Pressure) 06/05/1998 - "Methoxamine, a specific alpha1-selective adrenoceptor agonist, has proven to be useful in the treatment of hypotension, especially hypotension due to failure of the sympathetic nervous system. " 02/01/1998 - "Requirements for rescue methoxamine i.v. (27% vs 53%, P = 0.04, OR = 3.11) was less in group MX than in group HS but the dose of rescue methoxamine given (mean 6.3 (95% confidence intervals 3.0-9.6) vs 8.9 (5.6-12.2) mg) and time to onset of hypotension (20.7 (14.5-26.7) vs 17.3 (11.4-23.1) min) were similar in groups MX and HS, respectively. " 02/01/1998 - "Methoxamine 2 mg i.v. was given if systolic arterial pressure (SAP) decreased to < 100 mm Hg. Hypotension was defined as a 25% decrease from baseline SAP or mean arterial pressure (MAP). " 09/18/1958 - "[Methoxamine in peroperative hypotension]." 10/01/1977 - "Measurements during normotensive cardiopulmonary bypass were compared with values during intraoperative hypotension and subsequent normotension achieved following methoxamine infusion. "
3.	Portal Hypertension 06/01/1992 - "In conclusion, these in vitro results in mesenteric vessels demonstrate that 1) portal hypertension is accompanied by a hyporeactivity to the vasopressor methoxamine and 2) locally released NO in this preparation is responsible for the decreased vasoconstrictive response." 02/01/1987 - "The effects of beta-blockade with propranolol and of alpha-adrenergic stimulation with methoxamine, a powerful alpha-agonist, on azygos blood flow and on systemic and hepatic haemodynamics were investigated in 26 cirrhotic patients with portal hypertension. " 05/01/1996 - "In the present study, we have evaluated the involvement of protein kinase C (PKC) in the reduced pressor response to methoxamine (MTX) of a rat model of portal hypertension induced by partial portal vein ligation (PVL). " 12/01/2012 - "Cirrhotic portal hypertension is characterized by increased hepatic oxidative stress, AA (arachidonic acid)-derived TXA(2) (thromboxane A(2)) release and exaggerated hepatic response to the α-adrenergic agonist MTX (methoxamine). " 10/01/1992 - "We performed dose-response curves to methoxamine, an alpha-adrenoceptor agonist, with and without N omega-nitro-L-arginine, a specific inhibitor of nitric oxide synthesis, in experimental portal hypertension. "
4.	Contracture 05/01/1994 - "5. Contractures were prevented by prazosin at concentrations 2-3 log units higher than those which antagonized methoxamine-evoked inotropic responses. " 05/21/1990 - "In the pulmonary artery the contractures to methoxamine were inhibited more potently by APII (pD2 = 9.10 +/- 0.40, n = 6) than by the vasodilatory neuropeptide VIP (pD2 = 7.37 +/- 0.66, n = 6). " 08/01/1987 - "Exogenous VIP inhibited the methoxamine-evoked contractures in the atropine-blocked preparations with a lower potency in the inner, circular (pD2 = 6.4 +/- 0.5, n = 6) than in the outer, longitudinal layer (pD2 = 7.7 +/- 0.1, n = 6). " 01/01/1985 - "Alpha 1-adrenoceptor agonists (phenylephrine, methoxamine) induce contracture of the isolated bronchial smooth muscle (fig. " 05/01/1983 - "Contracture evoked by methoxamine 10(-4) M was impaired by prazosin 10(-8) M as well as by NIF 3 X 10(-10) M. "
5.	Necrosis 04/01/1962 - "Arterial necrosis caused by methoxamine: a comparison between acute experimental hypertensive arterial disease in the rat and lesions caused by a sympathomimetic amine." 07/01/1960 - "Arterial necrosis in the rat produced by methoxamine." 01/26/2004 - "Only the group given 0.3 mg ml(-1) epinephrine (not that given methoxamine) showed significantly greater necrosis than the control. " 11/01/1991 - "The ability to potentiate carbon tetrachloride-induced hepatic necrosis was shared by a compound with agonist effects relatively selective for alpha 2-adrenoreceptors (clonidine, 5 mg/kg, ip), but not by specific alpha 1-adrenoreceptor agonists (phenylephrine, up to 100 mg/kg, ip and methoxamine, up to 50 mg/kg, ip) or by the beta-adrenoreceptor agonist isoproterenol (up to 100 mg/kg, ip). "

Related Drugs and Biologics

1.	Epinephrine (Adrenaline)
2.	Clonidine (ST 155)
3.	Phenylephrine (Neo-Synephrine)
4.	Prazosin (Minipress)
5.	Isoproterenol (Isoprenaline)
6.	Angiotensin II
7.	Norepinephrine (Noradrenaline)
8.	Phentolamine (Z-Max)
9.	salicylhydroxamic acid (SHAM)
10.	NG-Nitroarginine Methyl Ester (L-NAME)

Related Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR)
2.	Ligation
3.	Epidural Anesthesia
4.	Resuscitation
5.	Injections