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Methohexital (Brevital)

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An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.

Also Known As:

Brevital; Methohexital Sodium; Brevimytal Natrium; Brietal; Brietal-Sodium; Jones Brand of Methohexital Sodium; Lilly Brand of Methohexital Sodium; Methohexital, Monosodium Salt; Brietal Sodium; Monosodium Salt Methohexital; Natrium, Brevimytal; Sodium, Methohexital; Methohexitone

Networked: 261 relevant articles (21 outcomes, 17 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 319
    - Pyrimidinones: 14
      - Barbiturates: 929
        Methohexital: 261
        4'-hydroxymethohexital

Experts

1.	Rasmussen, Keith G: 5 articles (09/2014 - 12/2006)
2.	Michael, Nikolaus: 2 articles (12/2011 - 03/2002)
3.	Petrides, Georgios: 2 articles (12/2009 - 09/2003)
4.	Morris, Harold H: 2 articles (10/2008 - 02/2007)
5.	Möddel, Gabriel: 2 articles (10/2008 - 02/2007)
6.	Loddenkemper, Tobias: 2 articles (10/2008 - 02/2007)
7.	Hooten, W Michael: 2 articles (09/2008 - 12/2006)
8.	Miner, James R: 2 articles (09/2003 - 04/2002)
9.	Plummer, David: 2 articles (09/2003 - 04/2002)
10.	Heegaard, William: 2 articles (09/2003 - 04/2002)

Related Diseases

1.	Seizures (Seizure) 03/01/2005 - "A recent period of unavailability of methohexital in the United States allowed for retrospective comparison of seizure length as well as clinical improvement in treatment using each agent. " 03/01/2013 - "This case documents a generalized tonic-clonic seizure in a 15-year-old girl after receiving 60 mg of methohexital and numerous prior episodes of bitemporal electroconvulsive therapy." 03/01/2013 - "In the adult literature, there are a few case reports of tonic-clonic seizures occurring immediately after the administration of methohexital. " 03/01/2013 - "Methohexital-induced seizures during electroconvulsive therapy." 02/01/2007 - "Nine of 222 patients had a seizure after methohexital injection (4.1%) (P=0.001). "
2.	Pain (Aches) 06/01/1992 - "The pain score for 1% methohexital in saline was significantly greater than those for the other two solutions (P less than 0.001 for each comparison). " 02/01/1977 - "If no relief from pain has been obtained a further 20 mg of methohexital are injected and the operation is repeated." 09/01/2012 - "Using the dilution method to reduce the pain associated with methohexital injection." 08/01/1989 - "Pain on injection of methohexitone. " 08/01/1985 - "Pain on injection was significantly less than with methohexitone. "
3.	Epilepsy (Aura) 04/01/1978 - "Although Brietal proved to be of value in the investigation of all forms of epilepsy, with 55% positive results, there remained groups of patients in whom there was still a call for greater diagnostic precision. " 09/01/1998 - "To explore the mechanism by which methohexital (MTH) activates epileptiform activity in patients with epilepsy, we examined the effects of MTH on hippocampal CA1 and neocortical neurons via extracellular and whole-cell patch-clamp recordings in rat brain slices. " 11/01/1997 - "Seventeen patients with intractable epilepsy were tested during intracarotid methohexital infusion. " 05/01/1997 - "Electrocorticography (ECOG) compared the effects of methohexital (MTH) and selective amygdalo-hippocampectomy (selAH) upon lateral temporal neocortical epileptiform activity (EA) in 31 patients with mesial temporal epilepsy. " 05/01/1997 - "Spontaneous and methohexital-induced spikes were studied in a group of 15 patients with temporomesial epilepsy using a 37-channel neuromagnetometer. "
4.	Vomiting 05/01/1991 - "The results showed that propofol was superior to methohexitone for most parameters, with small but statistically significant differences in response time, ambulation time, vomiting and drowsiness during recovery. " 01/01/1976 - "Frequency of nausea and vomiting after anaesthesia was considerably higher in the Althesin group than in the methohexitone group. " 04/01/1988 - "Propofol is particularly suitable for outpatient surgery since it provides superior operating conditions to methohexitone (particularly less movement), and rapid recovery in the postoperative period associated with a low incidence of nausea and vomiting. " 10/01/1998 - "A continuous infusion technique using either methohexital or propofol (50 to 100 microg/kg/min) was found to be safe and effective, with no clinically significant differences in cooperation, cardiopulmonary stability, recovery time, amnesia, comfort, and the incidence of nausea or vomiting. " 09/01/2003 - "Propofol may be a useful alternative to methohexital for the treatment of patients who have excessively long seizures and/or severe nausea and vomiting after ECT. "
5.	Amnesia (Dissociative Amnesia) 08/01/1973 - "Sodium methohexital amnesia for urethral instrumentation." 07/01/1968 - "[Method of anesthesia-amnesia-sedation using sodium methohexital during labor in continuous drip perfusion]." 03/01/1992 - "To compare the efficacy of propofol, methohexital, and midazalom in providing adequate sedation during administration of retrobulbar block and satisfactory postoperative amnesia. " 03/01/1971 - "Amnesia for brief exodontia procedures using small doses of diazepam and methohexital with local block anesthesia for ambulatory patients." 10/01/1998 - "A continuous infusion technique using either methohexital or propofol (50 to 100 microg/kg/min) was found to be safe and effective, with no clinically significant differences in cooperation, cardiopulmonary stability, recovery time, amnesia, comfort, and the incidence of nausea or vomiting. "

Related Drugs and Biologics

1.	Propofol (Diprivan)
2.	Alfentanil (Alfenta)
3.	Lidocaine (Xylocaine)
4.	Thiopental (Pentothal)
5.	Midazolam (Versed)
6.	remifentanil (Ultiva)
7.	barbituric acid (barbiturate)
8.	Fentanyl (Sublimaze)
9.	Anesthetics (Anesthetic Agents)
10.	Alfaxalone Alfadolone Mixture

Related Therapies and Procedures

1.	Anesthesia
2.	Injections
3.	Dilatation and Curettage (D&C)
4.	Intensive Care (Surgical Intensive Care)
5.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)