Methisazone (Metisazone)

An antiviral agent effective against pox viruses.

Also Known As:

Metisazone; Marboran; Hydrazinecarbothioamide, 2-(1,2-dihydro-1-methyl-2-oxo-3H-indol-3-ylidene)-

Networked: 49 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiosemicarbazones: 649
    - Methisazone: 49
      - TSKI-VI: 1
      - N-methylisatin beta-4',4'-diethylthiosemicarbazone
- Semicarbazides: 7
  - Semicarbazones: 67
    - Thiosemicarbazones: 649
      - Methisazone: 49
        TSKI-VI: 1
        N-methylisatin beta-4',4'-diethylthiosemicarbazone
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Methisazone: 49
        TSKI-VI: 1
        N-methylisatin beta-4',4'-diethylthiosemicarbazone

Experts

1.	Kern, Earl R: 2 articles (08/2006 - 03/2005)
2.	Modi, Palmi: 1 article (07/2020)
3.	Sagar, Sneha R: 1 article (07/2020)
4.	Shah, Bhumi: 1 article (07/2020)
5.	Keith, Kathy A: 1 article (08/2006)
6.	Quenelle, Debra C: 1 article (08/2006)
7.	McLean, Donald M: 1 article (06/2006)
8.	Jyoti, Mayank: 1 article (03/2005)
9.	Pandeya, Surendra Nath: 1 article (03/2005)
10.	Prichard, Mark N: 1 article (03/2005)

Related Diseases

1.	Smallpox (Variola) 11/01/1971 - "Field trials of methisazone as a prophylactic agent against smallpox." 02/08/1964 - "CONTROLLED TRIAL OF MARBORAN ON GROUP VACCINATED AGAINST SMALLPOX." 03/01/2005 - "Methisazone is an effective compound against variola and vaccinia viruses. " 01/01/2003 - "One of the derivatives, methisazone, was even investigated in the prophylaxis of smallpox. " 04/01/1983 - "Because of the eradication of smallpox, methisazone has become obsolete as a prophylactic agent in smallpox."
2.	Vaccinia 01/01/1970 - "[Attempt at treatment with methisazone of an infant with vaccinia and herpes simplex viruses]." 03/16/1967 - "Methisazone in progressive vaccinia." 06/01/2006 - "Vaccinia complications and methisazone therapy." 03/04/1977 - "Methisazone therapy in pediatric vaccinia complications." 04/01/1977 - "Methisazone is effective in prevention of smallpox and in the treatment of complications of vaccinia."
3.	Infections 11/11/1966 - "A study of adenovirus 11 under single-cycle conditions showed that multiplication of the virus, was completely inhibited by 30 microM methisazone when addition of the compound was delayed until 13 hours after infection. " 08/01/2006 - "Viral replication in liver, spleen and kidney was delayed or reduced by 100-to 10,000-fold by 10 mg/kg of marboran, but not IBT, in VV infections. " 04/01/1968 - "Studies of adenovirus type 3 infection treated with methisazone and trifluorothymidine." 01/01/2003 - "Other classes of compounds that have not been sufficiently studied in lethal infection models and deserve further consideration are thiosemicarbazones related to methisazone, and analogs of adenosine-N(1)-oxide and 1-(benzyloxy)adenosine." 08/01/2006 - "In vitro and in vivo evaluation of isatin-beta-thiosemicarbazone and marboran against vaccinia and cowpox virus infections."
4.	Infectious Mononucleosis (Glandular Fever) 04/01/1971 - "A pilot trial of methisazone in infectious mononucleosis and chcikenpox."
5.	Herpes Zoster 09/01/1983 - "[Treatment of herpes zoster with methisazone]." 07/01/1984 - "[Use of the Soviet antiviral preparation methisazone in herpes zoster]."

Related Drugs and Biologics

1.	Antiviral Agents (Antivirals)
2.	Immunoglobulins (Immunoglobulin)
3.	gamma-Globulins (gamma-Globulin)
4.	Trifluridine (Viroptic)
5.	Methisazone (Metisazone)
6.	Vaccines
7.	isatin beta-thiosemicarbazone
8.	Therapeutic Uses
9.	Type 2 Angiotensin Receptor
10.	Thiosemicarbazones

Related Therapies and Procedures

1.	Therapeutics
2.	Contraindications
3.	Drug Therapy (Chemotherapy)
4.	Debridement