Methionine Sulfoximine

01/01/2022 - "This hypothesis suggests that inhibiting glutamine synthetase with its well-characterized inhibitor, methionine sulfoximine, might prove therapeutic in cases of hepatic encephalopathy, a conclusion supported by their subsequent studies in animals. "
08/01/1989 - "A model of hepatic encephalopathy can be produced using methionine sulfoximine to inhibit irreversibly the enzyme glutamine synthetase, resulting in elevated brain ammonia levels and development of Alzheimer type II astrocytosis. "

08/01/1963 - "(A STUDY OF THE EXPERIMENTAL EPILEPSY INDUCED WITH METHIONINE SULFOXIMINE. "
08/01/1963 - "[RESEARCH FOR BEHAVIORAL AND ELECTROENCEPHALOGRAPHICAL CHANGES IN THE EXPERIMENTAL EPILEPSY INDUCED WITH METHIONINE SULFOXIMINE. "
05/01/2013 - "The experimental model of seizures which depends upon methionine sulfoximine (MSO) simulates the most striking form of human epilepsy. "
01/01/2010 - "In various animals methionine sulfoximine (MSO) induces tonic-clonic seizures resembling the most striking form of human epilepsies. "
01/01/2009 - "Animals subjected to methionine sulfoximine develop seizures similar to the most striking form of human epilepsy, with a long pre-convulsive period of several hours, a long convulsive period during up to 48 hours and a post convulsive period during which they recover normal behavior. "

12/01/2009 - "The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study."
09/01/2012 - "Rats were chronically infused with methionine sulfoximine (MSO, n=4) into the hippocampal formation to induce GS deficiency and recurrent seizures. "
10/01/2010 - "We selected two lines of mice based upon their latency to methionine sulfoximine (MSO) dependent-seizures: MSO-Fast and MSO-Slow, and their neurochemical characterization was attempted in order to look for the mechanisms of epileptogeny. "
01/01/2010 - "Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures."
07/15/1990 - "In this case, methionine sulfoximine failed to induce seizures. "

02/01/1977 - "Ultrastructural study of methionine sulfoximine-induced Alzheimer type II astrocytosis."
02/01/1975 - "Alzheimer II astrocytosis following methionine sulfoximine."
08/01/1989 - "A model of hepatic encephalopathy can be produced using methionine sulfoximine to inhibit irreversibly the enzyme glutamine synthetase, resulting in elevated brain ammonia levels and development of Alzheimer type II astrocytosis. "
12/15/1983 - "The enzymes of glutamate metabolism were estimated in astrocytes isolated from brains of normal rats and those injected with the potent convulsant, methionine sulfoximine (MSO), which inhibits glutamine synthetase and induces Alzheimer type II astrocytosis. "

02/01/1990 - "Further study of the mechanisms by which methionine sulfoximine decreases infarct volume could lead to new therapeutic approaches for stroke."