Methionine Sulfoximine

12/01/2009 - "The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study."
09/01/2012 - "Rats were chronically infused with methionine sulfoximine (MSO, n=4) into the hippocampal formation to induce GS deficiency and recurrent seizures. "
07/01/2011 - "To investigate the neurochemical changes that underlie seizure susceptibility we studied four strains of mice that respond differently to the convulsant methionine sulfoximine (MSO). "
10/01/2010 - "We selected two lines of mice based upon their latency to methionine sulfoximine (MSO) dependent-seizures: MSO-Fast and MSO-Slow, and their neurochemical characterization was attempted in order to look for the mechanisms of epileptogeny. "
01/01/2010 - "Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures."

08/01/1963 - "(A STUDY OF THE EXPERIMENTAL EPILEPSY INDUCED WITH METHIONINE SULFOXIMINE. "
08/01/1963 - "[RESEARCH FOR BEHAVIORAL AND ELECTROENCEPHALOGRAPHICAL CHANGES IN THE EXPERIMENTAL EPILEPSY INDUCED WITH METHIONINE SULFOXIMINE. "
09/01/1964 - "[A STUDY OF FREE AMINO ACID METABOLISM IN THE BRAIN TISSUE UNDERLYING METHIONINE SULFOXIMINE SEIZURE--A STUDY OF THE EXPERIMENTAL EPILEPSY INDUCED WITH METHIONINE SULFOXIMINE. "
05/01/2013 - "The experimental model of seizures which depends upon methionine sulfoximine (MSO) simulates the most striking form of human epilepsy. "
01/01/2010 - "In various animals methionine sulfoximine (MSO) induces tonic-clonic seizures resembling the most striking form of human epilepsies. "

02/01/1977 - "Ultrastructural study of methionine sulfoximine-induced Alzheimer type II astrocytosis."
02/01/1975 - "Alzheimer II astrocytosis following methionine sulfoximine."
08/01/1989 - "A model of hepatic encephalopathy can be produced using methionine sulfoximine to inhibit irreversibly the enzyme glutamine synthetase, resulting in elevated brain ammonia levels and development of Alzheimer type II astrocytosis. "
12/15/1983 - "The enzymes of glutamate metabolism were estimated in astrocytes isolated from brains of normal rats and those injected with the potent convulsant, methionine sulfoximine (MSO), which inhibits glutamine synthetase and induces Alzheimer type II astrocytosis. "

02/01/1990 - "Further study of the mechanisms by which methionine sulfoximine decreases infarct volume could lead to new therapeutic approaches for stroke."

07/01/2011 - "The aim of this study was to test if intrathecal application to the rat medulla of the astroglial glutamine synthetase inhibitor methionine sulfoximine (MSO) can influence the central sensitization of MDH nociceptive neurons and the animal's associated behaviour that are manifested in a model of chronic pulpitis pain induced by exposure of a mandibular molar pulp. "