HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Methadone (Dolophine)

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

Also Known As:

Dolophine; Methadose; Amidone; Biodone; Biomet Brand of Methadone Hydrochloride; Esteve Brand of Methadone Hydrochloride; Generics Brand of Methadone Hydrochloride; GlaxoSmithKline Brand of Methadone Hydrochloride; Mallinckrodt Brand of Methadone Hydrochloride; Martindale Brand of Methadone Hydrochloride; Metadol; Metasedin; Methaddict; Methadone Hydrochloride; Methex; Pharmascience Brand of Methadone Hydrochloride; Phenadone; Phymet; Physeptone; Pinadone; Pinewood Brand of Methadone Hydrochloride; Rosemont Brand of Methadone Hydrochloride; Roxane Brand of Methadone Hydrochloride; Symoron; Yamanouchi Brand of Methadone Hydrochloride; addiCare Brand of Methadone Hydrochloride; Hydrochloride, Methadone; 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-

Networked: 2985 relevant articles (228 outcomes, 468 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Ketones: 431
  - Methadone: 2985

Experts

1.	Adelson, Miriam: 28 articles (10/2015 - 08/2003)
2.	Peles, Einat: 24 articles (10/2015 - 02/2005)
3.	Schreiber, Shaul: 21 articles (10/2015 - 02/2005)
4.	Jones, Hendrée E: 17 articles (11/2015 - 09/2004)
5.	Kreek, Mary Jeanne: 17 articles (09/2013 - 01/2002)
6.	Krantz, Mori J: 16 articles (09/2015 - 09/2002)
7.	O'Grady, Kevin E: 16 articles (09/2013 - 07/2005)
8.	Bruera, Eduardo: 13 articles (02/2015 - 02/2002)
9.	White, Jason M: 13 articles (01/2014 - 10/2003)
10.	Kaltenbach, Karol: 12 articles (09/2013 - 11/2002)

Related Diseases

1.	Pain (Aches) 04/01/2010 - "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain. " 01/01/2012 - "When dosed appropriately on carefully chosen patients, methadone can be a very safe and effective choice in managing chronic pain. " 11/01/2005 - "The randomized trial demonstrated a statistically significant improvement in pain for methadone (20 mg/day) compared to placebo. " 08/01/2013 - "Patients rotated to methadone from high opioid doses had a two-point improvement in median pain scale scores after conversion (p=0.039). " 07/01/2013 - "The intensity of spontaneous pain was significantly decreased after the methadone treatment compared to placebo on the category verbal scale (50% improved after the methadone treatment, none after the placebo, p=0.031). "
2.	Opioid-Related Disorders (Opiate Addiction) 10/01/2000 - "Reviews issued by the Institute of Medicine and the National Institutes of Health have defined narcotic addiction as a chronic medical disorder and have claimed that methadone maintenance coupled with social services is the most effective treatment for this condition. " 03/20/1991 - "Despite methadone treatment having been found effective in cases of opiate-dependence, and in many cases a prerequisite of rehabilitation, the queues for it are very long in Sweden--up to two years. " 01/01/2001 - "The new proposal for rule making (NPRM) will help the medical profession accept methadone treatment as beneficial for opiate addiction and realize that it should be more accessible to patients from trained physicians in the community. " 01/01/2015 - "Methadone maintenance therapy is an effective treatment for opiate dependence, but more than three-quarters of persons receiving the treatment report sleep quality disturbances. " 10/09/1976 - "Methadone was not found to be "the quick cure" for opiate addiction. "
3.	Substance-Related Disorders (Drug Abuse) 09/18/1989 - "A significant minority of patients has benefited from methadone maintenance therapy, but most patients have continued their drug abuse and drug-related life-styles." 02/01/1977 - "It has been shown that while poor and middle class communities show good results with methadone maintenance approaches, in the area of secondary drug abuse they show marked dissimilarities. " 05/01/2002 - "In conclusion, INH retention time and completion rates were significantly improved by methadone treatment combined with observed INH, whether or not substance abuse counseling was provided. " 03/01/2011 - "A randomized trial of substance abuse treatment programs tested whether "enhanced profiles," consisting of feedback and coaching about performance indicators, improved the performance of residential, methadone, and detoxification programs. " 12/01/2008 - "This study examines the efficacy of the Focus on Families project (currently called Families Facing the Future), a preventive intervention to reduce substance use disorders among children in families with a parent in methadone treatment. "
4.	Heroin Dependence (Heroin Abuse) 07/01/2006 - "The results confirm that, in a nonexperimental clinical practice setting, BUP is as effective as methadone in the treatment of heroin dependence, with significantly better opiate abuse control, thus possibly allowing longer and more effective treatment programs with reduced relapse rates." 03/01/2010 - "Finally, L-, but not D,L-methadone seems to be more effective in reducing additional heroin abuse." 06/01/2008 - "Heat and pain thresholds were measured by quantitative sensory testing (QST) in 23 subjects with heroin dependence in full, sustained remission months after detoxification from methadone and 27 healthy non-drug using controls. " 07/15/2008 - "ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence." 03/01/2007 - "Methadone maintenance therapy has been the mainstay of treatment for heroin addiction since the 1970s. "
5.	Neoplasms (Cancer) 05/01/2014 - "Four articles were obtained in the first search, and from the second 7 clinical trials, none of them specific to methadone use in elderly patients with cancer. " 03/01/2012 - "The aim of this study was to retrospectively review the chart of cancer patients switched to methadone for unfavorable response to the previous opioid. " 12/01/2011 - "Methadone maintenance and cancer risk: an Israeli case registry study." 09/01/2008 - "The objective of this study is to describe methadone use as primary opioid analgesic for advanced pediatric cancer over a 6.5-year period. " 05/01/2014 - "There are insufficient data on the use of methadone as an analgesic in the elderly with cancer. "

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Buprenorphine (Subutex)
3.	2-methylcyclopentadienyl manganese tricarbonyl (MMT)
4.	Heroin (Diamorphine)
5.	Opioid Analgesics (Opioids)
6.	Fentanyl (Sublimaze)
7.	Cocaine (Cocaine HCl)
8.	Oxycodone (Oxycontin)
9.	Opioid Receptors (Opioid Receptor)
10.	Meperidine (Pethidine)

Related Therapies and Procedures

1.	Analgesia
2.	Palliative Care (Palliative Medicine)
3.	Opiate Substitution Treatment
4.	Intravenous Anesthesia
5.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)