Metallothionein

A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.

Also Known As:

Networked: 1427 relevant articles (29 outcomes, 187 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dziegiel, Piotr: 19 articles (02/2016 - 01/2004)
2.	Cai, Lu: 19 articles (12/2015 - 03/2003)
3.	Penkowa, Milena: 17 articles (09/2010 - 01/2002)
4.	Hidalgo, Juan: 16 articles (02/2015 - 01/2002)
5.	Kang, Y James: 14 articles (09/2015 - 03/2003)
6.	Adam, Vojtech: 13 articles (01/2016 - 08/2009)
7.	Kizek, Rene: 13 articles (01/2016 - 08/2009)
8.	Zabel, Maciej: 12 articles (02/2016 - 11/2003)
9.	Bay, Boon-Huat: 11 articles (05/2011 - 01/2002)
10.	Hidalgo, J: 11 articles (12/2006 - 05/2000)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "p53 and metallothionein may be helpful in the typing of borderline and malignant ovarian tumors. " 01/01/2012 - "In conclusion, p53, p21, bax, c-kit, and metallothionein may be helpful for the typing of ovarian tumors as benign, borderline and malignant or serous and mucinous. " 01/01/2012 - "Recent studies have investigated the expression of proliferative markers, but little is known about the expression of metallothioneins (MT) in different histological subtypes of this cancer and their impact on proliferation intensity in BCC. " 01/01/2009 - "Previous studies have provided some evidence of a possible association between cancer and metallothioneins. " 04/01/2006 - "Clinicopathological study of metallothionein immunohistochemical expression, in benign, borderline and malignant ovarian epithelial tumors."
2.	Anoxia (Hypoxia) 01/01/2016 - "This metallothionein response to freezing is likely adaptive and possibly provides protection against freeze-induced elevated metal concentrations in the cytosol and excess ROS levels due to hypoxia during freezing. " 07/01/2014 - "An increased expression of hypoxia-inducible factor-1α and metallothionein was noted in the study group compared with the control group (P < 0.05). " 01/01/2014 - "The present study was to explore the effect of metallothionein (MT) on intermittent hypoxia (IH) induced aortic pathogenic changes. " 02/01/2009 - "Our study shows that upregulation of metallothionein expression by hypoxia activates the HIF-HRE system through the ERK/mTOR pathway and may be a novel defense against hypoxia." 02/01/2001 - "To study the relationship of Metallothionein (MT) and antioxidases in hypoxia/reoxygenation (H/R) and hypoxic preconditioning (HPC). "
3.	Ischemia 10/25/2010 - "The aim of the present study was to investigate whether metallothionein was involved in the protection of lung ischemic preconditioning (IP) against lung ischemia-reperfusion (I/R) injury. " 10/01/2003 - "Previous studies using a cardiac-specific metallothionein (MT)-overexpressing transgenic mouse model have demonstrated that MT inhibits ischemia/reperfusion-induced myocardial injury. " 11/01/2002 - "To study the possibility of metallothionein (MT) participating in the process of ischemia/reperfusion protection. " 08/01/2009 - "The ischemia-reperfusion sequence was associated with a significant decrease in cardiac metallothionein levels. " 07/01/2009 - "CCPA can increase the level of metallothionein during ischemia-reperfusion, which may be part of the molecular mechanism of CCPA delayed preconditioning on cardioprotection."
4.	Breast Neoplasms (Breast Cancer) 12/15/2007 - "Recent studies have shown that only breast cancer epithelial cells with intact p53 can induce metallothionein (MT) synthesis after exposure to metals. " 01/01/1998 - "The goal of this study was to determine which of the 10 functional metallothionein (MT) genes are expressed in four human breast cancer cell lines and whether expression varies among the cell lines. " 10/15/2015 - "Metallothionein 2A expression and its relation to different clinical stages and grades of breast cancer in Egyptian patients." 02/01/2014 - "Metallothionein 2A genetic polymorphisms and risk of ductal breast cancer." 05/01/2011 - "Targeting metallothionein for prognosis and treatment of breast cancer."
5.	Inflammation 07/01/2015 - "To compare the metallothionein (MT) immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour (KOT), to correlate MT with cellular proliferation, and to evaluate the influence of inflammation in MT. " 05/01/2014 - "Metallothioneins have been linked to IBDs, but their role in intestinal inflammation is inconclusive. " 01/01/2013 - "In particular, because metallothionein (MT) is induced by inflammatory stress, its roles in inflammation are implied. " 01/01/2013 - "Genes linked to inflammation, bacterial response, chemotaxis and angiogenesis were down-regulated in adipocytes from UC compared to CD, whereas genes related to metallothioneins, apoptosis pathways and growth factor binding were up-regulated. " 01/01/2012 - "Metallothionein deficiency exacerbates chronic inflammation associated with carcinogenesis in stomach of mice infected with Helicobacter pylori."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Zinc
3.	P-Glycoprotein
4.	Protein Isoforms (Isoforms)
5.	Cytokines
6.	Glutathione S-Transferase pi
7.	Glutathione Transferase (Glutathione S-Transferase)
8.	Cytochrome P-450 Enzyme System (Cytochrome P450)
9.	NG-Nitroarginine Methyl Ester (L-NAME)
10.	Ions

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Injections
3.	Homologous Transplantation (Allograft)
4.	Transplants (Transplant)
5.	Nephrectomy