Metabolic Diseases (Metabolic Disease)

Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)

Also Known As:

Networked: 3200 relevant articles (99 outcomes, 256 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Obesity
2.	Inflammation
3.	Neoplasms (Cancer)
4.	Hypertension (High Blood Pressure)
5.	Insulin Resistance

Experts

1.	Wajner, Moacir: 15 articles (10/2015 - 09/2002)
2.	Seckl, Jonathan R: 10 articles (03/2012 - 06/2004)
3.	Jakóbkiewicz-Banecka, Joanna: 8 articles (10/2015 - 01/2005)
4.	Odermatt, Alex: 8 articles (07/2015 - 02/2009)
5.	Blüher, Matthias: 8 articles (11/2014 - 11/2006)
6.	Auwerx, Johan: 8 articles (12/2012 - 12/2006)
7.	Stumvoll, Michael: 7 articles (10/2015 - 11/2006)
8.	Weber, Anne: 7 articles (01/2015 - 03/2004)
9.	Tontonoz, Peter: 7 articles (07/2013 - 02/2002)
10.	Aburada, Masaki: 7 articles (10/2012 - 07/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Metabolic Diseases:

1.	Insulin (Novolin)FDA Link 01/01/2013 - "Experimental studies in animal models of metabolic disease have demonstrated their effects on improving lipid profile, insulin sensitivity, and reducing inflammatory responses. " 05/01/2012 - "Several lines of evidence suggest that 4-HNE could be involved in the pathophysiology of metabolic diseases; therefore, in this study we assessed the direct effects of 4-HNE on skeletal muscle insulin sensitivity. " 01/01/2011 - "The study of the role of TRP channels in the regulation of insulin release is of wide interest for fundamental research, evaluation of molecular mechanisms of disease and exploration of novel drug targets for metabolic diseases." 01/01/2010 - "In our recent study we decipher a new function for these factors in the control of insulin secretion and open up new avenues for the treatment of metabolic diseases, in particular type 2 diabetes." 09/01/2007 - "Further follow-up and longer-term studies are needed to explore the possibility that insulin sensitization therapy during puberty might reprogramme predisposition to metabolic disease."
2.	Glucose (Dextrose)FDA LinkGeneric 12/01/2015 - "Thus, PG seemed to induce a 2-step adaption to lactation, reducing the immediate postpartum nadir and peak of plasma concentration of glucose and BHB, respectively; which is beneficial for postpartum cows at high risk of lipid-related metabolic diseases. " 07/01/2015 - "Optogenetic technology shows great promise for understanding the mechanisms of glucose homeostasis and for developing treatments for metabolic diseases such as DM." 06/01/2014 - "Association between health-related quality of life and impaired glucose metabolism in Iran: the Qazvin Metabolic Diseases Study." 01/01/2013 - "Findings from this trial may lead to an effective intervention to assist women diagnosed with GDM to improve maternal glucose homeostasis and weight as well as stabilize infant growth trajectory, reducing the burden of metabolic disease across two generations. " 11/01/2010 - "This technique could represent a beneficial tool for future studies exploring the role of glucose metabolism in equine exercise performance and metabolic disease."
3.	HormonesIBA 01/01/2013 - "The current study suggests that targeting DGAT1 to enhance postprandial gut hormone secretion requires maximal inhibition, and suggests combination with DPP-4i as a potential strategy to develop DGAT1 inhibitors for treatment of metabolic diseases." 11/30/2011 - "It has potentially wide-ranging applications that encompass endocrinology, pharmacology, phenotypic analysis in genetic models of metabolic disease, and hormone discovery, and could also effectively limit the numbers of animals required for such studies." 08/01/2015 - "Irisin is a novel hormone which is related to many metabolic diseases. " 03/01/2015 - "Metabolic diseases and sex hormone levels affect differently in the development of cardiovascular and cerebrovascular diseases in elderly males." 01/01/2015 - "Irisin is a newly termed hormone that is related to metabolic diseases. "
4.	LigandsIBA 02/01/2015 - "Patent applications for expanding clinical application of PPARγ ligands to non-metabolic diseases, such as neurological and inflammatory diseases, and to skin whitening have been filed, and future studies are needed to elucidate the underlying mechanisms." 07/15/2013 - "FXR ligands have been investigated in preclinical studies for targeted therapy against metabolic diseases, but have shown limitations. " 08/11/2015 - "The newly discovered ligands can serve as chemical tools for further characterization of the SLC13 family or as lead molecules for the future development of potent inhibitors for the treatment of metabolic diseases and aging. " 08/01/2013 - "Designed multiple ligands in metabolic disease research: from concept to platform." 06/01/2012 - "The emerging discovery of novel endogenous orphan NR ligands and synthetic agonists has provided the foundation for therapeutic exploitation of the orphans in the treatment of metabolic disease."
5.	resveratrolIBA 07/01/2012 - "The phytochemical resveratrol has recently gained attention for its protection against metabolic disease. " 06/01/2010 - "The phytochemical resveratrol has recently gained attention for its protection against metabolic disease and for extension of life span, which have been linked to its metabolic effects and SIRT1 activation in fat cells. " 01/01/2009 - "Armed with the ability to prevent the deleterious effects of excess caloric intake and prevent detrimental cardiovascular events, resveratrol merits proper clinical investigations for its efficacy in treating metabolic diseases and CVD." 08/15/2015 - "The purpose of this study was to investigate if Z-TMS still shows potential for the prevention of metabolic diseases as known for resveratrol. " 11/01/2013 - "Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases."
6.	AdiponectinIBA 01/01/2013 - "Adiponectin is exclusively expressed in adipose tissues and exhibits protective effects against cardiovascular and metabolic diseases. " 10/16/2015 - "Adiponectin may have potential therapeutic applications in metabolic disease. " 10/01/2014 - "The discovery of GTDF as an adiponectin mimetic provides a promising therapeutic tool for the treatment of metabolic diseases." 04/01/2014 - "Adiponectin, extensively studied in metabolic diseases, exerts anti-diabetic, anti-atherogenic and anti-inflammatory activities. " 12/01/2013 - "Elevation of adiponectin levels is a potential therapeutic tool against cardiovascular and metabolic diseases. "
7.	Carbon MonoxideIBA 01/01/2014 - "The most frequent co-morbidities in the study group were cardiac, vascular, locomotor, sensory organs and metabolic diseases. " 05/01/2012 - "Pre-pregnancy counselling and co-management of high risk medical patients by obstetricians and specialist physicians with an understanding of the relationship between pregnancy and inherited metabolic disease is essential." 07/01/2011 - "Therefore, CO can be studied in the search for potential therapeutic targets for metabolic diseases via inhibition of inflammatory response and ER stress." 07/01/2011 - "The role of carbon monoxide in metabolic disease." 01/01/2008 - "Post-translational modifications of nuclear co-repressor RIP140: a therapeutic target for metabolic diseases."
8.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 08/01/2014 - "Studies indicate that fish and omega-3 polyunsaturated fatty acids (n3-PUFA) supplements may help prevent cardiovascular and metabolic diseases. " 01/01/2014 - "Polyunsaturated fatty acids (PUFAs) may protect against metabolic diseases. " 02/01/2013 - "In Western countries, this epidemic of metabolic disease has coincided with a marked increase in the intake of omega-6 polyunsaturated fatty acids (omega-6 PUFA), leading to suggestions that the two may be causally related. " 12/01/2013 - "Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) are not synthesized by the human body; they must be derived from dietary sources and they have been known to be involved with neurological, cardiovascular, cerebrovascular, autoimmune and metabolic diseases, and cognitive disorder as well as mood disorders. " 01/01/2014 - "Saturated fatty acids (SFA) are a risk factor for, whereas unsaturated fatty acids (UFA) are thought to be protective against, developing metabolic diseases. "
9.	NAD (NADH)IBA 04/01/2010 - "In this review, we will provide an integrated view on: 1) the pathways that control NAD(+) production and cycling, as well as its cellular compartmentalization; 2) the signaling and transcriptional pathways controlled by NAD(+); and 3) novel data that show how modulation of NAD(+)-producing and -consuming pathways have a major physiological impact and hold promise for the prevention and treatment of metabolic disease." 06/06/2012 - "In line with this premise, decreased activity of PARP-1 or CD38-both NAD(+) consumers-increases NAD(+) bioavailability, resulting in SIRT1 activation and protection against metabolic disease. " 06/01/2015 - "The primary functions of the DPN molecular network were inflammatory response, metabolic disease, cellular assembly and organization. " 06/01/2013 - "Being intimately associated with the cells' metabolism, it is expected that alterations to the NAD(+)/NADH ratio are to be found in situations of metabolic diseases, as is the case of diabetes. " 04/01/2013 - "Our results show that CD38 is a novel pharmacological target to treat metabolic diseases via NAD(+)-dependent pathways."
10.	Anti-Obesity Agents (Antiobesity Drugs)IBA 09/07/2013 - "As obesity and its associated metabolic diseases become a worldwide epidemic, the demand for novel anti-obesity agents is increasing. " 09/01/2002 - "It is anticipated that new anti-obesity drugs for this serious, multifaceted metabolic disease will become as safe and effective and as medically accepted as the treatment of other metabolic disorders such as hypertension, dyslipidaemia or Type 2 diabetes mellitus. " 08/01/2007 - "Weight loss through improved nutrition, increased physical activity, and weight loss agents (ie, orlistat and sibutramine) improves adiposopathy and improves many metabolic diseases whose prevalence are directly associated with an increase in body fat and sedentary lifestyle. "

Therapies and Procedures

1.	Liver Transplantation 01/01/2012 - "Liver transplantation offers a definitive cure for many liver and metabolic diseases. " 08/01/1997 - "In metabolic diseases, improved understanding of the underlying genetic and molecular defects will lead to advances in medical therapy and perhaps a decreased need for liver transplantation. " 09/01/2010 - "Liver transplantation in children with metabolic diseases: the studies of pediatric liver transplantation experience." 03/01/2003 - "We studied pediatric liver transplantation for metabolic disease in a large national cohort to determine whether smaller studies suggesting a survival advantage for these recipients could be corroborated. " 07/01/2014 - "These findings have positive implications for the control of metabolic diseases, which are common in patients after liver transplantation."
2.	Bariatric Surgery 02/01/2013 - "The superior efficacy of bariatric surgery compared with intensive medical treatment in reversing metabolic disease is now well accepted, but the critical mechanisms remain unknown. " 11/01/2010 - "Our study show that the preoperative treatment with a balanced energy formula diet as were included in our protocol in patients undergoing bariatric surgery improves statistical better their overall conditions, lowers cardiovascular risk and metabolic diseases that the patients with regular diet alone." 06/01/2014 - "Bariatric surgery is a well-established approach to improve metabolic disease in morbidly obese patients with high cardiovascular risk. " 01/01/2014 - "In this review, we examine the developing indications for the use of bariatric surgery in metabolic disease. " 01/01/2014 - "Bariatric surgery: the indications in metabolic disease."
3.	Drug Therapy (Chemotherapy) 06/01/2014 - "We utilized published consensus guidelines (GL) to benchmark the efficacy of standard pharmacotherapy for these metabolic diseases, and 881 patients met the study design criteria. " 03/01/1997 - "It has proved to be a powerful research tool with which to study inherited metabolic diseases, renal disease, drug metabolism, and toxicity, and can be used to monitor the effects of drug therapy. " 10/01/2014 - "Bile acid signaling in metabolic disease and drug therapy." 05/01/2014 - "The potential of modulating the epicardial fat with targeted pharmacological agents can open new avenues in the pharmacotherapy of endocrine and metabolic diseases. " 01/01/2014 - "Clinically, increased MAT is associated with age, metabolic diseases, drug treatment, and marrow recovery in children receiving radiation and chemotherapy. "
4.	Transplantation (Transplant Recipients) 01/01/2015 - "Our study marks the first time a human metabolic disease is induced in an experimental animal model by human hepatocyte transplantation and treated by gene therapy. " 12/01/2001 - "We are not far from new clinical trials with hepatocyte transplantation in humans for the treatment hereditary metabolic diseases. " 09/01/2015 - "Cord blood (CB) transplantation slows neurodegeneration during certain inherited metabolic diseases. " 06/01/2015 - "Cord blood (CB) transplantation slows neurodegeneration during certain inherited metabolic diseases. " 03/01/2014 - "The applications, outcomes and future strategies of hepatocyte transplantation (HTx) as a corrective intervention for inherited metabolic disease (IMD) are described. "
5.	Transplants (Transplant) 11/01/1993 - "The 5-year survival of the whole group was 78.1% without any significant difference regarding type of transplant, indications (with the best results: 89.4% 5-year survival obtained in 41 children grafted for metabolic diseases), or age (the 5-year survival was 82.2% for the 41 infants transplanted under the age of 1 year, 78.9% for the 124 children transplanted between 1 and 3 years, and 81.3% for the 96 children transplanted between 6 and 15 years). " 04/01/2008 - "Although individual results are encouraging, different treatment protocols, difficulties in the objective assessment of function of the transplant, and finally the lack of a controlled study make it difficult to judge the overall significance of LCT in the treatment of metabolic diseases and call for collaborative clinical research." 03/01/2013 - "Some infectious and metabolic diseases have been transmitted to the recipient via marginal donor grafts. " 11/01/2012 - "Our preliminary data, although in a small series of CLL patients, suggest that the metabolic findings revealed at first PET-CT after transplant seem to predict the patient outcome and to assess the metabolic disease status earlier than clinical evaluation by standard criteria. " 04/01/2011 - "Children with G/M who received a living donor liver transplant from heterozygote parents did well without any signs of expressing underlying metabolic disease. "