Mesonephroma

A rare tumor of the female genital tract, most often the ovary, formerly considered to be derived from mesonephric rests. Two varieties are recognized: (1) clear cell carcinoma, so called because of its histologic resemblance to renal cell carcinoma, and now considered to be of muellerian duct derivation and (2) an embryonal tumor (called also ENDODERMAL SINUS TUMOR and yolk sac tumor), occurring chiefly in children. The latter variety may also arise in the testis. (Dorland, 27th ed)

Also Known As:

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Carcinoma (Carcinomatosis)
2.	Clear Cell Adenocarcinoma
3.	Neoplasms (Cancer)

Experts

1.	Longacre, Teri A: 1 article (09/2012)
2.	Offman, Saul L: 1 article (09/2012)
3.	Kato, Noriko: 1 article (11/2009)
4.	Motoyama, Teiichi: 1 article (11/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mesonephroma:

1.	Diethylstilbestrol (Stilbestrol)FDA Link 11/01/1982 - " 3 data sources have been particularly important for continued assessment of DES: the 1951 University of Chicago double-blind study following controls, treated women, and offspring; the National Cooperative Diethylstilbestrol Adenosis (DESAD) project which collects information on thousands of women exposed in utero, and the Registry of Clear-Cell Adenocarcinoma (Mesonephroma) of the Genital Tract in Young Females. " 09/01/2012 - "From the initial designation of ovarian clear cell adenocarcinoma as "mesonephroma" to the linkage between vaginal clear cell carcinoma and diethylstilbestrol exposure in utero, gynecologic tract clear cell tumors have puzzled investigators, posed therapeutic dilemmas for oncologists, and otherwise presented major differential diagnostic challenges for pathologists. "
2.	Hepatocyte Nuclear Factor 1-betaIBA 11/01/2009 - "Recent microarray analyses have disclosed that HNF-1beta is aberrantly up-regulated in clear cell carcinoma of the ovary, which is a carcinoma of müllerian nature, but which was initially misnamed "mesonephroma". "
3.	GlycogenIBA 01/01/1987 - "Because glycogen-rich clear cell carcinomas of the lower urinary tract do not resemble ultrastructurally mesonephric remnants or carcinomas known to arise from them, these glycogen-rich clear cell carcinomas should not be called "mesonephromas" as has been the practice."