Mescaline (Peyote)

Hallucinogenic alkaloid isolated from the flowering heads (peyote) of Lophophora (formerly Anhalonium) williamsii, a Mexican cactus used in Indian religious rites and as an experimental psychotomimetic. Among its cellular effects are agonist actions at some types of serotonin receptors. It has no accepted therapeutic uses although it is legal for religious use by members of the Native American Church.

Also Known As:

Networked: 101 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jones, Grant: 2 articles (01/2022 - 01/2022)
2.	Lipson, Joshua: 2 articles (01/2022 - 01/2022)
3.	Nock, Matthew K: 2 articles (01/2022 - 01/2022)
4.	Holze, Friederike: 1 article (01/2022)
5.	Liechti, Matthias E: 1 article (01/2022)
6.	Ricard, Jocelyn A: 1 article (01/2022)
7.	Nichols, David E: 1 article (07/2021)
8.	Walter, Hannes: 1 article (07/2021)
9.	Kempley, Eilís: 1 article (12/2019)
10.	Aday, Jacob S: 1 article (07/2019)

Related Diseases

1.	Psychotic Disorders (Schizoaffective Disorder) 10/01/2004 - "A case of prolonged peyote-induced psychosis resolved by sleep." 07/01/1998 - "Blood flow and cerebral laterality in the mescaline model of psychosis." 12/01/1992 - "Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: experimental psychosis as a tool for psychiatric research." 09/01/1989 - "Right hemisphere involvement in mescaline-induced psychosis." 01/01/2016 - "These accounts identified thought insertion as one of the self-disturbances (from German: "Ichstörungen") of schizophrenia and used mescaline as a model-psychosis in healthy individuals to explore the possible mechanisms. "
2.	Alcoholism (Alcohol Abuse) 01/01/2023 - "Improvement in mental well-being and its ability to overcome alcoholism render mescaline potentially beneficial in clinical settings. " 01/01/2009 - "Peyote also has some evidence for alcoholism treatment among Native Americans. " 12/01/2000 - "Jesus, peyote, and the holy people: alcohol abuse and the ethos of power in Navajo healing." 01/01/1977 - "Peyote, a potential ethnopharmacologic agent for alcoholism and other drug dependencies: possible biochemical rationale." 11/01/1974 - "Peyote in the treatment of alcoholism among American Indians."
3.	Substance-Related Disorders (Drug Abuse) 01/01/2006 - "The results of this exploratory study suggest that illicit peyote use is uncommon among AI adolescents with serious substance abuse problems." 01/01/2006 - "Illicit peyote use among American Indian adolescents in substance abuse treatment: a preliminary investigation." 10/15/2005 - "Compared to Navajos with minimal substance use, the peyote group showed no significant deficits on the RMHI or any neuropsychological measures, whereas the former alcoholic group showed significant deficits (p < .05) on every scale of the RMHI and on two neuropsychological measures. " 01/01/2006 - "Illicit peyote users did not differ from nonusers in terms of age, gender, other substance use, prevalence of either other substance abuse/dependence or other nonsubstance use psychiatric disorders. " 01/01/2017 - "Challenges in Laboratory Detection of Unusual Substance Abuse: Issues with Magic Mushroom, Peyote Cactus, Khat, and Solvent Abuse."
4.	Shock 12/01/1981 - "Mescaline and reactivity to foot shock--a dose response study." 01/01/1981 - "These experiments demonstrate an interaction between shock, which presumably is a stressor, and mescaline. " 01/01/1981 - "Mescaline given to shock rats had no effect on acquisition even though levels of acquisition were the same for both shock and nonshock rats without drug. " 01/01/1981 - "Inescapable shock alters mescaline's disruption of active avoidance acquisition." 05/01/1978 - "Several measures of aggressive behavior were investigated in three ages (40-50, 90-110, and 180-200 days old) and in three strains (Sprague-Dawley, Wistar, and Long-Evans) of rats before and following the administration of mescaline hydrochloride in a shock-elicited aggression situation. "
5.	Schizophrenia (Dementia Praecox) 05/01/1968 - "Studies on mescaline XIX: a new theory concernig the nature of schizophrenia." 01/01/2016 - "These accounts identified thought insertion as one of the self-disturbances (from German: "Ichstörungen") of schizophrenia and used mescaline as a model-psychosis in healthy individuals to explore the possible mechanisms. " 07/01/1957 - "The effects of mescaline sulfate in chronic schizophrenia." 09/01/1951 - "VIII. Experimental tests in schizophrenia; lysergic acid diethylamide and mescaline]." 08/25/1951 - "VIII. Experimental tests in schizophrenia: lysergic acid diethylamide and mescaline]."

Related Drugs and Biologics

1.	Methamphetamine (Desoxyn)
2.	Lysergic Acid Diethylamide (LSD)
3.	Hallucinogens (Psychedelics)
4.	Psilocybin (Psilocibin)
5.	Lysergic Acid
6.	Sulfates (Sulfates, Inorganic)
7.	Mescaline (Peyote)
8.	N,N-Dimethyltryptamine (Dimethyltryptamine)
9.	Serotonin (5 Hydroxytryptamine)
10.	5-HT2A Serotonin Receptor (5 HT2A Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections