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Tiopronin (Thiola)

Sulfhydryl acylated derivative of GLYCINE.

Also Known As:

Thiola; 2-Mercaptopropionylglycine; 2-Thiol-propionamido-acetic Acid; 2-Thiolpropionamidoacetic Acid; Acadione; Aventis Brand of Tiopronin; Captimer; MIT Gesundheit Brand of Tiopronin; Meprin; Tiopronine; alpha-Mercaptopropionylglycine; 2 Mercaptopropionylglycine; 2 Thiol propionamido acetic Acid; 2 Thiolpropionamidoacetic Acid; Acid, 2-Thiol-propionamido-acetic; Acid, 2-Thiolpropionamidoacetic; Tiopronin Aventis Brand; alpha Mercaptopropionylglycine; Mercaptopropionylglycine; Thiopronine; Glycine, N-(2-mercapto-1-oxopropyl)-

Networked: 258 relevant articles (10 outcomes, 28 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Becker-Pauly, Christoph: 14 articles (08/2015 - 05/2007)
2.	Bond, Judith S: 14 articles (03/2014 - 02/2003)
3.	Stöcker, Walter: 10 articles (12/2012 - 10/2002)
4.	Sterchi, Erwin E: 10 articles (10/2012 - 10/2002)
5.	Lottaz, Daniel: 7 articles (01/2011 - 10/2002)
6.	Matters, Gail L: 5 articles (02/2011 - 01/2005)
7.	Arnold, Philipp: 3 articles (08/2015 - 05/2015)
8.	Prox, Johannes: 3 articles (08/2015 - 05/2015)
9.	Shah, Sudhir V: 3 articles (05/2013 - 03/2002)
10.	Banerjee, Sanjita: 3 articles (02/2011 - 06/2005)

Related Diseases

1.	Alcoholic Fatty Liver 06/01/2012 - "To study the protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats. " 06/01/2012 - "Protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats." 06/01/2012 - "Tiopronin exerts protective effects against non-alcoholic steatohepatitis in rats, which may be associated with its antioxidant properties and regulation of lipid metabolism." 08/01/2010 - "Acupoint catgut embedding is an effective method for the treatment of non-alcoholic steatohepatitis and this therapy is superior to oral administration of Tiopronin and Xuezhikang capsule."
2.	Proteinuria 10/01/2014 - "Proteinuria in the nephrotic range may spontaneously remit after tiopronin withdrawal. " 06/01/2001 - "It must be emphasized that patients treated with tiopronin should be screened for proteinuria." 10/01/2014 - "Withdrawal of tiopronin-induced proteinuria complete remission and clinical resolution of nephrotic syndrome. " 02/01/1990 - "cent) discontinuation of the thiopronine because of nephrotic syndrome (3 case) and proteinuria (5 cases). " 05/01/1983 - "Pemphigus foliaceus and proteinuria induced by alpha-mercaptopropionylglycine."
3.	Neoplasms (Cancer) 06/01/2015 - "This study compares fluorescence and photoacoustic (PA) imaging of ex vivo tumors and organs from tumor-bearing mice injected intravenously with ultrasmall (<3 nm ) tiopronin-capped Au nanoparticles and compares the data with inductively coupled plasma mass spectrometry (ICP-MS). " 02/01/2013 - "This study describes the basic intracellular characteristics of Tiopronin-Au nanoparticles from the standpoint of their anti-cancer activity in different cancer cell cultures." 05/22/2012 - "Surprisingly, both 2 and 6 nm [email protected] nanoparticles were distributed throughout the cytoplasm and nucleus of cancer cells in vitro and in vivo, whereas 15 nm [email protected] nanoparticles were found only in the cytoplasm, where they formed aggregates. " 01/01/2011 - "Sera from cancer patients exhibited reduced meprin-α inhibition compared to healthy controls. " 01/01/2011 - "The impact of increased meprin-α levels on tumor progression is not known. "
4.	Chronic Hepatitis (Chronic Active Hepatitis) 01/01/1982 - "The efficacy of tiopronin (2-mercaptopropionyl glycine) 600 mg daily in the treatment of chronic active or chronic persistent hepatitis has been assessed in a double-blind controlled clinical trial of 12 weeks involving 165 Japanese patients with histologically proven disease. " 01/01/1982 - "The results of this short-term study indicate that tiopronin may be of value in the treatment of chronic hepatitis." 01/01/1982 - "Therapeutic effects of tiopronin on chronic hepatitis: a double-blind clinical study." 12/01/1981 - "Follow-up study in chronic active hepatitis after therapies with immunosuppressive drugs and tiopronin." 01/01/1980 - "Having used 2-mercaptopropionylglycine in successful treatment of chronic hepatitis the mode of action of the reagent was further studied in rat liver mitochondrial membrane. "
5.	Reperfusion Injury 03/01/2008 - "Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice." 03/01/2002 - "Radical shifts in the localization of an activated enzyme to potentially sensitive areas of the tubule suggest a toxic role for meprin in ischemia-reperfusion injury. " 03/01/2002 - "The second objective was to determine if inhibition of meprin is protective against hypoxia-reoxygenation injury in vitro and ischemia-reperfusion injury in vivo. " 06/01/1998 - "Since in our in vitro studies, we identified a distinct meprin-induced 55 kDa nidogen breakdown product, the urine was also examined for the presence of nidogen degradation products after rat renal ischemia-reperfusion injury. "

Related Drugs and Biologics

1.	Zinostatin
2.	Free Radicals
3.	Oxygen
4.	xuezhikang
5.	sulfosalicylic acid
6.	Penicillamine (Cuprimine)
7.	Metalloproteases (Metalloproteinases)
8.	Cystine (L-Cystine)
9.	Zinc
10.	Glycine (Aminoacetic Acid)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration
3.	Acupuncture Points (Acupuncture Point)
4.	Catgut
5.	Injections