Merbromin (Mercurochrome)

A once-popular mercury containing topical antiseptic.

Also Known As:

Mercurochrome; Merbromine; 2,7 Dibromo 4 Hydroxymercurifluoresceine; 2,7-Dibromo-4-Hydroxymercurifluoresceine; Mercury, (2',7'-dibromo-3',6'-dihydroxy-3-oxospiro(isobenzofuran-1(3H),9'-(9H)xanthen)-4'-yl)hydroxy-, disodium salt

Networked: 68 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Erlank, Erica: 1 article (12/2022)
2.	Koekemoer, Lizette L: 1 article (12/2022)
3.	Venter, Nelius: 1 article (12/2022)
4.	Bianchi, Leonardo: 1 article (01/2022)
5.	Caroppo, Elena Sofia: 1 article (01/2022)
6.	Hansel, Katharina: 1 article (01/2022)
7.	Marietti, Rossella: 1 article (01/2022)
8.	Stingeni, Luca: 1 article (01/2022)
9.	Tramontana, Marta: 1 article (01/2022)
10.	Alkhashrom, Sewar: 1 article (12/2021)

Related Diseases

1.	Otomycosis 01/01/1996 - "Otomycosis--a clinico-mycological study and efficacy of mercurochrome in its treatment." 11/01/2001 - "Mercurochrome is recommended as a safe and economical drug for the topical treatment of otomycosis in developing countries like Nigeria." 11/01/2001 - "Otomycosis in Nigeria: treatment with mercurochrome." 11/01/2001 - "Three topical drugs, namely mercurochrome, clotrimazole and locacorten-vioform, were evaluated for otomycosis therapy in separate groups of 24 patients each. "
2.	Infections 12/01/2021 - "More importantly, merbromin was found to inhibit HCMV infection of cells in three different assays, as well as to disrupt HCMV NEC nuclear rim formation. " 12/01/2015 - "During our observation period, fewer infections were noted with merbromin treatment. " 08/01/2001 - "Mercurochrome significantly decreased local infection, especially before surgery, but its effect in decreasing fistula formation, although appreciable, was not statistically significant. " 12/01/2022 - "To detect infection within the mosquito and/or to assess the efficacy of antimalarial compounds, the midguts of the female mosquitoes were removed post infection and were stained with mercurochrome. " 04/01/1993 - "Two new methods were recently introduced for the determination and quantification of egg viability in Schistosoma haematobium infections by staining eggs filtered from urine on Nytrel filters with mercurochrome and iodine. "
3.	Hypersensitivity (Allergy) 01/01/1984 - "[Study of mercurochrome allergy]." 11/01/1997 - "We describe eight patients suffering from Mercurochrome allergy. " 11/01/1997 - "Mercurochrome allergy. " 01/01/1994 - "Mercurochrome allergy: concurrence of 2 hypersensitivity mechanisms in the same patient." 03/01/1985 - "Anaphylactic hypersensitivity to mercurochrome (merbrominum)."
4.	Burns 01/01/1983 - "[Mercury poisoning caused by topical treatment of burns with merbromine (mercurochrome)]." 12/01/2017 - "Antiseptics versus topical antibioticsCompared with the topical antibiotic, SSD, there is low certainty evidence that, on average, there is no clear difference in the hazard of healing (chance of healing over time), between silver-based antiseptics and SSD (HR 1.25, 95% CI 0.94 to 1.67; I2 = 0%; 3 studies; 259 participants); silver-based antiseptics may, on average, increase the number of healing events over 21 or 28 days' follow-up (RR 1.17 95% CI 1.00 to 1.37; I2 = 45%; 5 studies; 408 participants) and may, on average, reduce mean time to healing (difference in means -3.33 days; 95% CI -4.96 to -1.70; I2 = 87%; 10 studies; 979 participants).There is moderate certainty evidence that, on average, burns treated with honey are probably more likely to heal over time compared with topical antibiotics (HR 2.45, 95% CI 1.71 to 3.52; I2 = 66%; 5 studies; 140 participants).There is low certainty evidence from single trials that sodium hypochlorite may, on average, slightly reduce mean time to healing compared with SSD (difference in means -2.10 days, 95% CI -3.87 to -0.33, 10 participants (20 burns)) as may merbromin compared with zinc sulfadiazine (difference in means -3.48 days, 95% CI -6.85 to -0.11, 50 relevant participants). "
5.	Ganglion Cysts (Ganglion) 04/01/2019 - "In addition, significant degeneration was detected in Corti organs, spiral ganglions and stria vascularis in groups 2 and 3. In this study, it was observed that mercurochrome use in external otitis and otitis media with tympanic membrane perforation could cause ototoxicity and concluded that the solution should be used cautiously."

Related Drugs and Biologics

1.	Antimalarials (Antimalarial Agents)
2.	Solutions
3.	Local Anti-Infective Agents (Antiseptics)
4.	Coloring Agents (Dyes)
5.	Xanthenes
6.	Sulfadiazine (Sulphadiazine)
7.	Sodium Hypochlorite (Clorox)
8.	Silver Sulfadiazine (SSD)
9.	Silver
10.	Rose Bengal

Related Therapies and Procedures

1.	Therapeutics
2.	Thermometers
3.	Conservative Treatment
4.	Hydrocolloid Bandages (Duoderm)
5.	Parathyroidectomy