Meperidine (Pethidine)

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.

Also Known As:

Networked: 1376 relevant articles (119 outcomes, 162 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Ho, Shung-Tai: 6 articles (04/2014 - 06/2004)
2.	Evron, Shmuel: 4 articles (05/2007 - 06/2002)
3.	Ezri, Tiberiu: 4 articles (05/2007 - 06/2002)
4.	Unlugenc, Hakki: 3 articles (02/2015 - 01/2008)
5.	Sessler, Daniel I: 3 articles (07/2014 - 05/2003)
6.	Lin, Tso-Chou: 3 articles (04/2014 - 07/2012)
7.	Lu, Chih-Cherng: 3 articles (04/2014 - 06/2004)
8.	Rowe, Brian H: 3 articles (02/2013 - 04/2005)
9.	Hsu, Hsao-Hsun: 3 articles (03/2012 - 04/2003)
10.	Kuo, Shuenn-Wen: 3 articles (03/2012 - 04/2003)

Related Diseases

1.	Pain (Aches) 07/01/2004 - "The study was terminated after recruitment of the first 50 women when planned interim analysis showed a significantly greater reduction of VAS pain score in the pethidine group (P= 0.009). " 10/01/2014 - "Standardization of opioid administration was improved significantly in the CPGT group, including more frequent pain evaluation (P<0.001), more standardized dosing titration (P<0.001), and less frequent meperidine prescriptions (P<0.001). " 07/01/2012 - "The reduction in pain was significantly greater in the pethidine group only at 15 minutes (P=0.004). " 11/19/1977 - "This mixture was used with 51 patients (37 to 85 years old) with beneficial results on pain in 4 cases out of 5. This effect can be improved by giving a small amount of pethidine with the inhalation. " 11/01/1984 - "Submucous paracervical blockade is superior to intramuscular meperidine as pain relief during labor. "
2.	Postoperative Pain 01/01/1992 - "We conclude PCA with pethidine is effective for postoperative pain in patients after upper abdominal surgery, but administered doses in this study is not enough to achieve complete relief of postoperative pain in view of the serum level of pethidine." 01/01/2013 - "The present study shows that preemptive intra-articular pethidine 50 mg injection is more effective than preventive injection for postoperative pain relief at rest and joint movement in arthroscopic knee surgery." 11/01/1999 - "The goal of the present study was to examine whether pethidine administration before skin incision is more effective in reducing postoperative pain than the same dose of pethidine given intraoperatively. " 01/01/2013 - "Several previous studies have evaluated the efficacy of intra-articular (IA) pethidine as a compound, which has local anesthetic and opioid agonist properties, on postoperative pain relief in arthroscopic knee surgery (AKS). " 04/01/2008 - "In this study, we helped patients, who underwent 1-level, first-time lumbar microdiscectomy have a postoperative pain-free and comfortable period by using epidural meperidine-impregnated AFFGs."
3.	Renal Colic 01/01/1991 - "pethidine in acute renal colic. " 12/01/1988 - "Supra-malleolar acupuncture substituting for pethidine in appeasement of renal colic." 01/01/1999 - "These results show that intramuscular ketorolac as a single agent for renal colic is more effective than meperidine and promotes earlier discharge of renal colic patients from the ED." 04/01/2000 - "In the doses studied, single-dose IV ketorolac is as effective as titrated IV meperidine for the relief of acute renal colic and causes less functional impairment." 01/01/1999 - "To compare the efficacy of intramuscular ketorolac and meperidine in the emergency department (ED) treatment of renal colic, a prospective, controlled, randomized, double-blind trial was conducted in an academic ED with 76,000 annual visits. "
4.	Vomiting 01/01/2005 - "The incidence of emesis was significantly lower (1 of 35; 2.9%) in the peribulbar group compared with the meperidine group (9 of 35; 25.6%) (P <.01) in the first 24 hours. " 06/12/2004 - "Pethidine was associated with a higher rate of vomiting. " 08/01/1993 - "Though the group with pethidine had a longer duration of analgesia and sedation, the very high incidence of vomiting and delay in urination observed in this group would preclude the use of pethidine routinely. " 09/01/2011 - "Nausea and vomiting and drowsiness were mild and occurred only in the pethidine group. " 03/01/2011 - "Nausea and vomiting occurred more frequently with higher doses of meperidine (P < 0.001 and P = 0.003, respectively). "
5.	Migraine Disorders (Migraine) 12/01/2008 - "The relative efficacy of meperidine for the treatment of acute migraine: a meta-analysis of randomized controlled trials." 03/01/2002 - "Opioid use, particularly meperidine, exceeds that of recommended nonopioid abortive migraine medications." 06/01/1999 - "Home use of Demerol for migraine." 12/01/2008 - "Clinicians should consider alternatives to meperidine when treating acute migraine with injectable agents." 03/01/2011 - "Three studies reported subjective headache relief with a butyrophenone versus placebo or meperidine in migraine. "

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Ketorolac
3.	Fentanyl (Sublimaze)
4.	Tramadol
5.	Meperidine (Pethidine)
6.	Diazepam (Valium)
7.	Diclofenac (SR 38)
8.	Lidocaine (Xylocaine)
9.	Opioid Analgesics (Opioids)
10.	Acetaminophen (Paracetamol)

Related Therapies and Procedures

1.	Analgesia
2.	Premedication
3.	Tourniquets
4.	Epidural Analgesia
5.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)