Meningococcal Infections

09/01/2012 - "Polysaccharide vaccines against serogroups A, C, W-135, and Y were developed but they were not so effective in protecting infants, who are at particularly high risk from invasive meningococcal infections. "
11/01/1985 - "Vaccines effective against meningococcal infection are available and have been widely employed. "
08/01/2005 - "Taken together, the results of this study confirmed the immunogenicity of TspA in humans during natural meningococcal infection, and therefore, TspA is worthy of further investigation as a possible T-cell stimulating component of future vaccines."
06/01/1996 - "Vaccines against group B meningococcal infection tested in several field trials have all been extracts of the outer membrane of the bacteria. "
11/01/2012 - "The use of polyvalent conjugate carbohydrate-based vaccines has decreased the meningococcal infection around the world. "

01/01/1996 - "Protection against meningococcal infection has been correlated with serum bactericidal antibodies, therefore, it is important for these vaccine candidates to generate such antibodies. "
02/01/2014 - "The data demonstrate clearly the presence of meningococcal antibodies in healthy individuals with no history of meningococcal infection and a wide diversity of immune responses. "
10/01/2011 - "Analysis of the specificity of bactericidal antibodies in normal, convalescent, and postvaccination human sera is important in understanding human immunity to meningococcal infections and can aid in the design of an effective group B vaccine. "
01/01/2010 - "meningitidis B antibodies in serum of patients with meningococcal infections. "
01/01/2010 - "The results endorse the lack of clinical recurrences once antibodies are present, whereas in C7Q0 patients the anti-meningococcal antibodies may not suffice to protect from recurrent meningococcal infection."

10/01/1983 - "[Efficacy of penicillin therapy of meningococcal infection in children undergoing different regimes of pathogenetic therapy]."
05/01/2006 - "Uniform penicillin susceptibility has been assumed for meningococcal infections for many years, but decreased penicillin susceptibility has been recognized recently with increasing frequency. "
12/01/1998 - "The vast majority of GPs in Birmingham would apparently give benzyl penicillin to a patient they suspected had meningococcal infection. "
08/01/1997 - "In recent years an increase has been observed in the prevalence of meningococcal infection by Neisseria meningitidis serogroup C and in the appearance of strains with moderate resistance to penicillin. "
07/01/1996 - "Seven patients with meningococcal infection received benzyl penicillin before admission. "

01/01/2013 - "To study the effectiveness, adverse events and development of drug resistance of different antibiotics as prophylactic treatment regimens for meningococcal infection. "
01/01/2013 - "Randomised controlled trials (RCTs) or quasi-RCTs comparing antibiotics versus placebo or no intervention, in people with suspected meningococcal infection, or different antibiotics administered before admission to hospital or confirmation of the diagnosis. "
03/01/2005 - "Prophylactic use of antibiotics for prevention of meningococcal infections: systematic review and meta-analysis of randomised trials."
11/01/2003 - "In this study, national and regional reference laboratories used a standardized methodology to determine the MICs of antibiotics used in the management of meningococcal infection. "
01/01/2013 - "Antibiotics for preventing meningococcal infections."

09/01/2015 - "Conjugate meningococcal vaccines have been shown to be more effective in preventing meningococcal infection in young children. "
04/01/2000 - "Future studies will need to focus on the potential vaccine prevention of the increased risk of meningococcal infection in persons of high school age, particularly as new conjugate meningococcal vaccines become available."
03/01/2003 - "As more effective meningococcal vaccines become available, recommendations for their use in nonepidemic settings should consider current epidemiologic trends, particularly changes in age and serogroup distribution of meningococcal infections."
01/01/2002 - "[Menomune: a tetravalent vaccine for the prophylaxis of meningococcal infections of types A, C, W135, Y]."
01/01/1993 - "We describe here the presentation and clinical course of systemic meningococcal infection in two HIV-1-seropositive men and the response to meningococcal vaccine in one. "

10/01/2012 - "Without iron, the Neisseriae cannot survive and, therefore, these iron import systems tend to be relatively well conserved and are promising vaccine targets, having the potential to offer broad protection against both gonococcal and meningococcal infections. "
01/01/1992 - "To examine the protective nature of the antibody response elicited by 6F9 we performed a series of live challenge studies using a murine model for meningococcal infection in which mice were iron dextran treated and challenged with 10 x LD50 of meningococcal group C strain 35E. "
01/01/1983 - "Mouse transferrin was used to specifically label the plasma transferrin iron pool for studies of iron kinetics in normal mice and infected mice during the hypoferremic phase of experimental meningococcal infection. "
08/15/1994 - "Using a model of meningococcal infection in BALB/c mice in which the animals are rendered susceptible with iron dextran, we studied the ability of this anti-id to protect adult mice against challenge. "
11/01/1984 - "Turpentine-induced hypoferremia was also found to provide a protective effect against meningococcal infection which could be partially reversed by exogenous iron. "

01/30/2003 - "Combined with data derived from genome-based approaches (such as reverse vaccinology) and immunogenicity studies, this novel transcriptome-based antigen identification should reveal ideal vaccine candidates against serogroup B meningococcal infection."
03/07/2006 - "Neisseria meningitidis serogroup C capsular polysaccharide (MenCPS) is an important antigen against meningococcal infection. "
07/14/2005 - "Identification of novel antigens that protect against systemic meningococcal infection."
08/01/1994 - "meningitidis strains isolated from 218 healthy carriers in 1989-1991 in closed communities of adults, irrespective of cases of meningococcal infection registered in these communities, were characterized with a variety of different type and subtype antigens. "
03/01/1990 - "The possible role of these structures as common Neisseria antigen in the formation of natural resistance to meningococcal infection is discussed."

03/01/1970 - "These studies are consistent with previous reports suggesting that immunization with group A and group C polysaccharides may well provide group-specific protection against meningococcal infections."
03/01/1970 - "Absorption studies with sera from patients with natural meningococcal infections revealed that these polysaccharides are the major antiphagocytic determinants for group A and group C meningococci. "
04/24/2008 - "Bacterial capsular polysaccharides covalently linked to an appropriate carrier protein represent the best tool to induce a protective immune response against a wide range of bacterial diseases, such as meningococcal infections. "
11/01/1988 - "The results of serological surveys, carried out with a view to the detection of capsular meningococcal polysaccharides in the passive hemagglutination (PHA) test and covering 1,289 patients with systemic meningococcal infection, 221 patients with bacteriologically confirmed meningococcal nasopharyngitis, 2,820 persons in organized groups of children and adults with different epidemiological situation (including 650 carriers) and 4,050 residents of 8 cities with different morbidity levels, were analyzed. "
01/01/2010 - "Capsular polysaccharides (CPS) are a major virulence factor in meningococcal infections and form the basis for serogroup designation and protective vaccines. "

06/01/1986 - "The significant reduction in CH50 and Factor B in the more severely affected patients suggests that activation of both classical and alternate pathways occurs in group B meningococcal infection."
06/01/1986 - "During an epidemic of group B meningococcal infection mean values obtained in 96 consecutively affected children showed a reduction in classical pathway function (CH50), normal alternate pathway function (AP50), C4 and factor B levels, and raised C3 levels. "
04/01/2005 - "To evaluate the functional activity of the classical and alternative pathways of the complement system and the levels of C3, C4, and factor B during the first episode of meningococcal infection and during the convalescence period. "
01/01/1983 - "The specific susceptibility to meningococcal infections was connected with half-normal levels of several components of the complement system (C3, C4, C9, factor B, properdin), and reduced antibody responses to group A and group C meningococcal polysaccharides, but not to several other polysaccharide or protein antigens."

01/01/2012 - "Thyroid hormone enhances nitric oxide-mediated bacterial clearance and promotes survival after meningococcal infection."
11/01/1975 - "Complex therapy with steroid hormones, antibiotics, oxygen, cardiac glycosides and vitamins was effective in meningococcal infections complicated by myo- and pericarditis but failed to prevent their development."

03/04/1989 - "To determine the incidence of secondary meningococcal infection in close family and household contacts of index patients and to review the efficacy of chemoprophylaxis the records of 3256 cases occurring from 1984 through 1987 were examined. "
03/01/2013 - "Public health action and mass chemoprophylaxis in response to a small meningococcal infection outbreak at a nursery in the West Midlands, England."
03/01/2003 - "[Prevention of secondary cases of invasive meningococcal infection: role of chemoprophylaxis and vaccination]."
12/01/2000 - "One hundred and fifty cases of probable meningococcal infection notified to the consultants in communicable disease control in a local health authority were reviewed to identify the proportion receiving chemoprophylaxis and to examine the final clinical outcome, in terms of diagnosis, of each case. "
12/01/1997 - "After four years following the vaccination and chemoprophylaxis strategy recommended in the Guidelines, set up by the National Reference Laboratory for Meningococcal Infections in 1993, it is possible to conclude, that there have been practically no secondary cases of invasive meningococcal disease in the Czech Republic."

11/01/2004 - "However, in family members of patients with meningococcal infection the risk of developing the disease during the following week is about one hundred times higher than in the general population and they should receive an antibiotic prophylaxis. "
05/01/2003 - "[Antibiotic prophylaxis against invasive meningococcal infection]."
11/01/1998 - "In January 1994 mass antibiotic prophylaxis was undertaken in the contiguous villages of Deir el-Asad and B'ine in northern Israel (combined population of 11600) in response to a prolonged outbreak of serogroup B meningococcal infection with an overall annual rate of 37.4 cases of infection per 100000 residents. "
06/01/2015 - "We recommend that children be vaccinated against invasive meningococcal infection before beginning eculizumab therapy and take appropriate antibiotic prophylaxis during treatment, and we suggest that vaccine responses should be checked and followed annually. "

05/01/2005 - "The meningococcal infection in these young children resulted in limb amputation and significant plastic surgery. "
04/01/1992 - "Amputation for gangrene of the limbs following severe meningococcal infection."
02/01/1991 - "Five cases of severe meningococcal infection in children and young adults with gangrene leading to major amputation are described. "
02/01/1991 - "Amputation for gangrene of the limbs following severe meningococcal infection."
01/01/1985 - "Gangrene requiring amputation in meningococcal infection."

05/01/2012 - "Administration of an LPS antagonist with antibiotic merits consideration in the emergency treatment of patients presenting with meningococcal infection."
12/01/1983 - "[Early diagnosis and emergency treatment of meningococcal infection]."
06/01/1980 - "[Emergency treatment of brain edema in meningococcal infection]."

09/01/2008 - "Single nucleotide polymorphisms in genes of circulatory homeostasis in surviving pediatric intensive care patients with meningococcal infection."
01/01/2007 - "This is the result of several factors such as the centralization of care of seriously ill children in paediatric intensive care units (PICUs), the establishment of specialized mobile intensive care teams, the development of protocols for the treatment of meningococcal infection, and the dissemination by national bodies and charities of guidance about early recognition and management. "