Aseptic Meningitis

A syndrome characterized by headache, neck stiffness, low grade fever, and CSF lymphocytic pleocytosis in the absence of an acute bacterial pathogen. Viral meningitis is the most frequent cause although MYCOPLASMA INFECTIONS; RICKETTSIA INFECTIONS; diagnostic or therapeutic procedures; NEOPLASTIC PROCESSES; septic perimeningeal foci; and other conditions may result in this syndrome. (From Adams et al., Principles of Neurology, 6th ed, p745)

Also Known As:

Networked: 701 relevant articles (18 outcomes, 41 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Meningitis
2.	Bacterial Meningitis
3.	Encephalitis (Encephalitis, Rasmussen)
4.	Headache (Headaches)
5.	Hydrocephalus (Hydrocephaly)

Experts

1.	Nakayama, Tetsuo: 4 articles (11/2015 - 01/2007)
2.	Nigrovic, Lise E: 3 articles (01/2014 - 10/2002)
3.	Malik, Tahir: 3 articles (07/2011 - 09/2007)
4.	Gendrel, Dominique: 3 articles (06/2009 - 07/2006)
5.	Chalumeau, Martin: 3 articles (06/2009 - 07/2006)
6.	Hayashi, T: 3 articles (11/2000 - 07/2000)
7.	Furukawa, S: 3 articles (11/2000 - 07/2000)
8.	Ichiyama, T: 3 articles (11/2000 - 07/2000)
9.	Nishikawa, M: 3 articles (11/2000 - 07/2000)
10.	Ito, Yuhei: 2 articles (11/2015 - 03/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aseptic Meningitis:

1.	SteroidsIBA 07/01/1998 - "One patient developed an aseptic meningitis 10 days after the study, which was successfully treated with steroids; no other complications were noted. " 10/01/2013 - "Two patients experienced aseptic meningitis treated with a 14-day course of steroids. " 01/01/2013 - "Intravenous steroids at presentation are helpful in managing the aseptic meningitis associated with rupture. " 09/01/1993 - "It is the purpose of this paper to reexamine the impact that steroids have made on the prevalence of the aseptic meningitis syndrome, and to review recent studies that have attempted to distinguish between aseptic and bacterial meningitis." 06/01/1998 - "Perioperative administration of steroids and wound protection may be beneficial for preventing the development of postoperative aseptic meningitis and hydrocephalus."
2.	Immunoglobulin G (IgG)IBA 08/01/1995 - "Most patients with aseptic meningitis showed little or no elevation of albumin ratio and IgG index. " 11/01/1991 - "The values for de novo IgG synthesis showed significant increase in all types of CNS inflammatory diseases except for the group with aseptic meningitis. " 11/23/1988 - "In one case a polyclonal increase in IgG synthesis, secondary to an aseptic meningitis, masked oligoclonal banding, which was confirmed on subsequent examination. " 08/01/1979 - "The immune response within the CNS in aseptic meningitis seems to be dominated by synthesis of IgG with lambda light chains." 01/01/1989 - "None of the CSF of normal controls, bacterial and viral meningitis cases gave positive antimycobacteria IgG by ELISA while 9.5% of the CSF of bacterial and 14.3% of aseptic meningitis cases gave positive results with IF. "
3.	Lactic AcidFDA LinkGeneric 01/01/2010 - "Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: a systemic review and meta-analysis." 01/01/2001 - "Increased total CSF lactate is an important indicator differentiating bacterial from aseptic meningitis. " 05/01/1992 - "In differential diagnosis between infectious and acute aseptic meningitis syndrome maximal sensitivity was a CRP value exceeding 0.5 mg/dl, a CSF lactate value of over 3 mmol/l and a CSF cell count of over 2000/3 cells. " 01/01/1986 - "Of 28 children with aseptic meningitis 3 had lactate in the range 2.5-2.7 mmol/l, while the others had values of 2.4 mmol/l or less. " 01/01/1983 - "These data suggest that the determination of cerebrospinal fluid lactic acid may be of diagnostic value in differentiating between bacterial and aseptic meningitis."
4.	RNA (Ribonucleic Acid)IBA 01/01/2013 - "Enteroviruses (EVs) are a major cause of aseptic meningitis, and RNA detection using molecular assay is the gold standard diagnostic test. " 12/01/2003 - "The purpose of this study was to compare the results of conventional virus isolation with those of enteroviral RNA detection by reverse transcription (RT)-PCR method in identical specimens from cases of suspected aseptic meningitis. " 10/01/1998 - "The aim of this study was to compare conventional enterovirus isolation with rapid detection of enteroviral RNA by a reverse transcription-nested polymerase chain reaction (RT-nPCR) method amplifying the 5' nontranslated region of the enteroviral genome in specimens from patients with aseptic meningitis. " 09/01/1992 - "This study proves the usefulness of the PCR assay for detection of enteroviral RNA in stool samples and suggests that the test may be an alternative to virus isolation for rapid enterovirus diagnosis in patients with aseptic meningitis." 09/01/2007 - "Cerebrospinal fluid (CSF) samples taken during May 2005-February 2006 from children admitted to the Children Hospital of Patras with signs of aseptic meningitis were tested for the presence of enteroviral RNA. "
5.	Interleukin-6 (Interleukin 6)IBA 08/01/1992 - "In conclusion, this study shows evidence that IL-6 is released into the meningeal space in aseptic meningitis and is correlated with the local acute inflammatory response." 08/01/2012 - "Group B (with aseptic meningitis): n = 27, average IL-6 level: 7.34 (median: 5; 25/75 percentiles: 0.0/15.1; 95% CI 3.94-10.73; range 0-23.6). " 06/01/1995 - "Furthermore, CSF IL-6 levels were 10 times greater in infants with bacterial versus aseptic meningitis (p < 0.001). " 04/01/2009 - "The CSF IL-6 levels in the bacterial meningitis group (45.2 +/- 50.0 pg/ml) were significantly higher than those in the aseptic meningitis group (12.9 +/- 10.2 pg/ml) and the nonmeningitis group (6.5 +/- 7.8 pg/ml; p < 0.05). " 01/01/2008 - "We suggest that IFN-gamma and IL-6 may be involved in both disease-associated and drug-induced aseptic meningitis, whereas CSF-anti-U1RNP Abs is detected only in a patient with MCTD-associated aseptic meningitis."
6.	Anti-Bacterial Agents (Antibiotics)IBA 09/01/2015 - "Human enteroviruses are the major cause of aseptic meningitis and are resistant to all known antibiotics and chemotherapeutic agents. " 06/01/2007 - "In centers where the turnaround time for these tests is less than 24 h, there can be substantial cost savings and avoidance of unnecessary treatment of aseptic meningitis with antibiotics. " 01/01/2015 - "To assess the impact of introducing EV-PCR on the use of antibiotics and hospital length of stay in aseptic meningitis. " 06/01/2009 - "This strategy ensures rapid treatment for bacterial meningitis, but also involves unnecessary admissions and antibiotics for aseptic meningitis. " 05/01/2009 - "Parenteral antibiotics are indicated for Lyme meningitis but not viral causes of aseptic meningitis. "
7.	C-Reactive ProteinIBA 09/01/2005 - "C reactive protein for differentiating bacterial from aseptic meningitis in Thai patients." 10/01/2000 - "Although determination of serum C-reactive protein (CRP) is considered one of the most useful tests for differentiating between bacterial and aseptic meningitis, its diagnostic accuracy in comparison with other laboratory parameters is yet to be further evaluated. " 03/17/1984 - "The presence of C-reactive protein in CSF obtained at first lumbar puncture therefore is unreliable to distinguish between bacterial and aseptic meningitis." 05/01/1983 - "Use of serum C-reactive protein in differentiating septic from aseptic meningitis in children." 12/01/1991 - "Quantitative C-reactive protein (CRP) was determined sequentially by nephelometry and photometry from a finger prick serum sample in 67 children with bacterial meningitis (BM) and 16 children with aseptic meningitis (AM). "
8.	Sulindac (Copal)FDA LinkGeneric 01/01/1989 - "After discontinuing sulindac, the aseptic meningitis improved in five days. " 11/01/1988 - "Recurrent sulindac-induced aseptic meningitis in a patient tolerant to other nonsteroidal anti-inflammatory drugs." 09/01/1983 - "Recurrent aseptic meningitis due to sulindac." 01/01/1982 - "Sulindac-induced aseptic meningitis." 02/01/2008 - "We report a case of aseptic meningitis thought to be associated with chronic sulindac use in a patient with osteoarthritis. "
9.	Adrenal Cortex Hormones (Corticosteroids)IBA 02/01/2015 - "For another CD patient, aseptic meningitis developed and was treated effectively with corticosteroids. " 10/01/2009 - "Behçet's disease should be listed as a differential diagnosis of acute aseptic meningitis because, in acute aseptic meningitis caused by Behçet's disease, early treatment with corticosteroids could ameliorate this disorder." 12/23/1967 - "Corticosteroids in aseptic meningitis." 08/01/2003 - "Spontaneous aseptic meningitis is rare and corticoids lower its development time, but hydrocephalus may occur as a complication due to upsets in the reabsorption of cerebrospinal fluid." 01/01/1999 - "Five patients with aseptic meningitis and 9 patients with viral encephalitis, who were moderately to severely ill, were examined for cerebrospinal fluid (CSF) parameters before and after short-term intravenous administration of corticosteroids. "
10.	AntigensIBA 11/01/2011 - "The aim of this work was to assess the efficacy of rapid antigen detection (RAD) assay for the confirmation of human enteroviruses in comparison to that of the conventional cell culture (CCC), and to identify the serotypes associated with aseptic meningitis cases in the Autonomous Province of Vojvodina. " 11/01/2011 - "Detection of enteroviruses in clinical samples of patients with aseptic meningitis by rapid antigen detection assay." 10/01/1979 - "HLA antigen frequencies were similar in patients with aseptic meningitis and controls. " 12/01/2002 - "We suspected that the two patients suffered from aseptic meningitis caused by allergic reaction, and the antigen for this abnormal allergic reaction was the foreign materials used for MVD. " 10/01/2009 - "They were divided into 3 groups according to the culture- or bacterial antigen assay-proven diagnosis and CSF findings: bacterial meningitis (n = 31), aseptic meningitis (n = 65), and non-meningitis (n = 61). "

Therapies and Procedures

1.	Critical Care 11/01/1988 - "Critical care personnel have a great deal of difficulty in differentiating aseptic meningitis from partially treated meningitis from bacterial meningitis. " 01/01/2011 - "A systematic review by Huy and colleagues in the previous issue of Critical Care summarizes data from 25 studies evaluating the role of CSF lactate in the differential diagnosis between acute bacterial and aseptic meningitis. "
2.	Drug Therapy (Chemotherapy) 03/01/2004 - "Drug-induced aseptic meningitis is an unusual complication of drug therapy. " 06/01/2003 - "Aseptic meningitis is a rare but well-recognized complication of drug therapy. " 03/01/1998 - "Aseptic meningitis due to intraventricular chemotherapy was seen in 7 patients (Group B patients). " 01/01/1980 - "The protein profile at the end of combined chemotherapy and radiotherapy was very similar to that in patients with acute aseptic meningitis. " 11/01/1997 - "In the majority of instances, catheter infections may be managed medically, as may the most common complications of intraventricular chemotherapy including aseptic meningitis (43% of patients) and myelosuppression (18%)."
3.	Catheters 04/01/2004 - "A malposition of a central venous catheter resulting in intrathecal infusion of parenteral nutrition and subsequent aseptic meningitis in a preterm neonate is presented. " 04/01/2004 - "[Aseptic meningitis after intrathecal infusion of a parenteral nutrition solution: examples of rare malpositions of central venous catheters in preterm neonates]." 11/01/1997 - "In the majority of instances, catheter infections may be managed medically, as may the most common complications of intraventricular chemotherapy including aseptic meningitis (43% of patients) and myelosuppression (18%)." 01/01/1993 - "Three minor complications (bleeding, aseptic meningitis, catheter infection) led to no sequelae. " 12/01/1992 - "Three complications (bleeding, aseptic meningitis, catheter infection) remained without sequelae. "
4.	Spinal Injections 01/01/1953 - "[Tetanus and aseptic meningitis caused by the initial intraspinal injection of serum]." 11/30/1921 - "It has been shown that an aseptic meningitis of 3 to 5 days duration and favorable prognosis can be induced in cats by intrathecal injection of sterile saliva filtrate from early cases of parotitis, and that such a meningitis can be transmitted to other cats by injecting the cerebrospinal fluid in the same manner. " 11/01/1970 - "Aseptic meningitis following the intrathecal injection of radioiodinated serum albumin." 07/01/1965 - "A CASE OF ASEPTIC MENINGITIS SECONDARY TO INTRATHECAL INJECTION OF I-131 HUMAN SERUM ALBUMIN." 03/01/1991 - "6) High GAD activities in CSF were observed in the acute phase of aseptic meningitis and after intrathecal injection of methotrexate for the therapy against meningeal leukemia. "
5.	Spinal Anesthesia 04/01/2000 - "Aseptic meningitis after spinal anesthesia in an infant." 07/01/1999 - "Aseptic meningitis after spinal anesthesia in an infant." 05/01/1985 - "Aseptic meningitis following spinal anesthesia--a complication of the past?" 11/01/1970 - "Aseptic meningitis following spinal anesthesia." 07/01/1964 - "ASEPTIC MENINGITIS FOLLOWING SPINAL ANESTHESIA. "