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Meningism (Meningismus)

A condition characterized by neck stiffness, headache, and other symptoms suggestive of meningeal irritation, but without actual inflammation of the meninges (MENINGITIS). Spinal fluid pressure may be elevated but spinal fluid is normal. (DeJong, The Neurologic Examination, 4th ed, p673)

Also Known As:

Meningismus; Dupre's Syndrome; Meningitis-Like Reaction; Dupres Syndrome; Meningisms; Meningitis Like Reaction; Meningitis-Like Reactions; Pseudomeningitides; Reaction, Meningitis-Like; Reactions, Meningitis-Like; Syndrome, Dupre; Syndrome, Dupre's; Dupre Syndrome; Pseudomeningitis

Networked: 66 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Fever (Fevers)
2.	Headache (Headaches)
3.	Meningitis
4.	Viral Meningitis
5.	Bacterial Meningitis

Experts

1.	Mayes, Michael: 2 articles (06/2015 - 06/2015)
2.	Richie, Alexa: 2 articles (06/2015 - 06/2015)
3.	Freeman, William D: 2 articles (06/2015 - 06/2015)
4.	Ng, Lauren K: 2 articles (06/2015 - 06/2015)
5.	Nagel, Jay: 2 articles (06/2015 - 06/2015)
6.	Dhakal, Laxmi P: 2 articles (06/2015 - 06/2015)
7.	Hodge, David O: 2 articles (06/2015 - 06/2015)
8.	Huang, Kevin T: 1 article (10/2015)
9.	Bi, Wenya Linda: 1 article (10/2015)
10.	Dunn, Ian F: 1 article (10/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Meningism:

1.	Ferritins (Ferritin)IBA 12/01/1986 - "Results of the study indicate that CSF ferritin levels are a valuable adjunct in the early evaluation of patients presenting with meningism." 12/01/1986 - "Cerebrospinal fluid ferritin levels in screening for meningism." 09/01/1993 - "The diagnostic value of cerebrospinal fluid (CSF) ferritin was assessed in 30 patients with meningeal reaction (viral meningitis 10; bacterial meningitis 6; meningism 14) and in 37 patients with cerebrovascular disease (cerebral infarction 29; transient ischaemic attacks 4; cerebral haemorrhage 4). "
2.	Lactic Acid FDA LinkGeneric 01/01/1991 - "Elevated lactate values (above 2.95) were also found in all the patients who had tuberculous meningitis and statistically they differed significantly from the cerebrospinal fluid values of the patients with viral meningitis and meningism (p less than 0.01). " 03/01/2011 - "Average blood and CSF-lactate levels were significantly higher in children with mitochondrial disorders (3.87 ± 0.48 and 4.43 ± 0.55 mmol/l) and meningitis (2.77 ± 0.45 and 8.58 ± 1.08 mmol/l) than in children with epilepsy (1.72 ± 0.13 and 1.62 ± 0.04 mmol/l), psychomotor retardation (1.79 ± 1.40 and 1.68 ± 0.06 mmol/l) or meningism (1.70 ± 0.13 and 1.64 ± 0.07 mmol/l). " 01/01/1979 - "Adenylate kinase activity and lactate concentration in patients with serous meningitis were significantly higher than in those with meningism. " 03/01/2011 - "To address this problem, we ascertained the diagnostic value of lactate and alanine in blood (B) and cerebrospinal fluid (CSF) in children with mitochondrial disorders (n = 24), epilepsy (n = 32), psychomotor retardation (n = 23), meningitis (n = 12) and meningism (n = 16). "
3.	IronIBA 09/01/1996 - "Clinical features included pyrexia, kwashiorkor, extensive ulcerating skin lesions suggestive of ecthyma gangrenosum, hepatomegaly, meningismus, neutropenia and iron deficiency anaemia. " 05/01/1991 - "Meningism following intravenous iron dextran." 08/20/1983 - "Meningism due to intravenous iron dextran."
4.	Glucose (Dextrose)FDA LinkGeneric 01/01/1975 - "When the patterns of CSF glucose concentration of the two groups were compared it was noted that patients suffering from acute meningitis showed generally a quicker and more profound rise of glucose levels after induced hyperglycaemia than patients with meningism. " 01/01/1975 - "The pattern of glucose CSF concentration after induced hyperglycaemia was studied in 14 patients suffering from acute meningitis and 10 having meningism, as judged by normal CSF. " 10/01/1993 - "The classic presentation consists of the acute onset of meningismus, headache, fever, malaise with pleocytosis and normal glucose and slightly elevated protein in the cerebrospinal fluid. " 04/01/1980 - "Tuberculous meningitis should be suspected, even in the infant or child with a negative tuberculin skin test, when a chronically ill patient presents with the acute signs of meningismus, the cerebrospinal fluid analysis demonstrates a low glucose and monocytosis, and cranial CT shows ventricular enlargement with prominent basal and sylvian fissure enhancement after intravenous contrast medium injection. "
5.	Muromonab-CD3 (Muromonab CD3)FDA Link 11/01/1990 - "Meningism in a ten-month-old infant during OKT3 therapy." 01/01/1988 - "One of the major side effects induced by the in vivo administration of the murine monoclonal antibody OKT3 is a spontaneously reversible clinical syndrome associating in variable proportions depending on the patient: fever, chills, headaches, diarrhea and seldomly meningismus. "
6.	OxygenIBA 08/01/2011 - "MTS high urgency discriminators include several known predictors of SBI, such as fever, work of breathing, meningism and oxygen saturation, but apply to non-SBI children as well. " 11/01/1995 - "Exclusion criteria were pregnancy, fever, signs of meningismus, altered sensorium, drug or alcohol use, oxygen saturation less than 90%, recent trauma or seizure, "worst headache," abnormal blood pressure, recent (within 48 hours) use of metoclopramide or prochlorperazine, and allergy to metoclopramide or prochlorperazine. "
7.	Interleukin-2 (IL2)IBA 01/01/1990 - "Elevated levels of soluble interleukin-2 receptors (S-IL-2R) but not interleukin-2 (IL-2) activity were found in sera from patients with aseptic meningitis, purulent meningitis, and meningism. " 01/01/2006 - "In the CSF samples of the 5 patients with meningism and the 17 with viral meningitis, the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, and IL-10 were determined using a cytometric bead array. "
8.	Immunoglobulin G (IgG)IBA 09/01/1990 - "IgG intrathecal synthesis was established in one patient with meningism. " 07/01/1982 - "Liquor:serum quotients of IgG and albumin in patients with meningism, meningitis and multiple sclerosis have been studied. " 07/01/1982 - "Liquor:serum quotients of IgG and albumin in patients with meningism, meningitis and multiple sclerosis."
9.	Dextrans (Dextran)FDA Link 05/01/1991 - "Meningism following intravenous iron dextran." 08/20/1983 - "Meningism due to intravenous iron dextran."
10.	Creatine Kinase (Creatine Phosphokinase)IBA 03/01/1985 - "Reference values for control patients with meningism were 16-269 U/1. In a subset of 9 patients creatine kinase isoenzyme analysis was performed. " 11/01/1994 - "Enzymatic determinations in cerebrospinal fluid (CSF) of aspartate aminotransferase (AST), lactic dehydrogenase (LDH), gammaglutamyl transpeptidase (GGT), creatine phosphokinase (CPK) and creatine kinase BB (CK-BB) were performed in 16 patients with aseptic meningitis (AM), in 25 children with bacterial meningitis (BM) and in 15 patients with meningism. "

Therapies and Procedures

1.	Mechanical Ventilators (Ventilator) 11/01/2006 - "Six children (86%) responded well with one or more of the following: a halt in progressive motor weakness, improvement in leg pains, meningismus, and straight-leg raising within 24 to 48 hours; one could be weaned off the ventilator by 60 hours. "
2.	Catheters 01/01/2011 - "Meningismus associated with malpositioned intraspinal catheter for drug delivery." 02/01/1990 - "The epidural catheter was removed on the third postoperative day, after which the patient complained of persistent lumbar pain which was associated with meningismus, fever, leucocytosis and a raised erythrocyte sedimentation rate. " 01/01/2011 - "Meningismus from malpositioned catheters is a rare complication that can mimic meningitis but should be considered in the differential for postimplant headaches. "
3.	Neurosurgical Procedures 06/01/2009 - "Viral reactivation should be considered in patients with fever, meningism and extended hospital admission following neurosurgical procedures." 09/01/1990 - "This is a report of fungal pseudomeningitis superimposed on a case of nosocomial Escherichia coli meningitis resulting from a neurosurgical procedure. "
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 05/01/2007 - "We present a 24-year-old female with a prodrome of facial pain without fever or meningismus, who developed a locked-in syndrome due to an invasive fungal infection after bone marrow transplantation. "
5.	Tooth Extraction (Tooth Extractions) 02/01/2001 - "The authors report the case of a 69-year-old man with a pituitary adenoma confirmed by neuroimaging results, in whom a high fever, meningismus, and left-sided ophthalmoplegia developed 4 days after tooth extraction. "