Meniere Disease (Menieres Disease)

A disease of the inner ear (LABYRINTH) that is characterized by fluctuating SENSORINEURAL HEARING LOSS; TINNITUS; episodic VERTIGO; and aural fullness. It is the most common form of endolymphatic hydrops.

Also Known As:

Networked: 606 relevant articles (59 outcomes, 86 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Vertigo (Positional Vertigo)
2.	Tinnitus
3.	Hearing Loss (Hearing Impairment)
4.	Dizziness (Lightheadedness)
5.	Sensorineural Hearing Loss

Experts

1.	Kitahara, Tadashi: 7 articles (07/2015 - 09/2002)
2.	Naganawa, Shinji: 6 articles (10/2011 - 03/2006)
3.	Horii, Arata: 5 articles (10/2013 - 05/2006)
4.	Ishiyama, Akira: 5 articles (09/2013 - 10/2006)
5.	Ishiyama, Gail: 5 articles (09/2013 - 10/2006)
6.	Sone, Michihiko: 5 articles (10/2011 - 03/2007)
7.	Nakashima, Tsutomu: 5 articles (10/2011 - 03/2007)
8.	Pirodda, Antonio: 4 articles (10/2012 - 01/2010)
9.	Borghi, Claudio: 4 articles (10/2012 - 01/2010)
10.	Kubo, Takeshi: 4 articles (04/2009 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Meniere Disease:

1.	Gentamicins (Gentamicin)FDA LinkGeneric 01/01/1997 - "Low-dose intratympanic gentamicin is a safe, simple, office procedure that is effective in controlling the definitive vertiginous episodes in most patients with unilateral Meniere's disease. " 12/01/2003 - "Intratympanic gentamicin appears effective in controlling the symptoms of Meniere's disease, regardless of the protocol used. " 06/01/1998 - "Intratympanic gentamicin treatment is a relatively safe and effective way to treat Meniere's disease. " 02/01/1994 - "Intratympanic gentamicin treatment is a relatively safe and effective way to treat bilateral Meniere's disease when the symptoms can be localized to one ear." 10/01/2001 - "Round Window Microcatheter-administered microdose gentamicin is an exciting new treatment for Meniere's disease. "
2.	Glycerol (Glycerine)FDA LinkGeneric 06/01/2005 - "[The control study of glycerol test in different stage of Meniere's disease patients]." 11/01/1985 - "Previous studies have shown that otoadmittance changes are a sensitive indicator of glycerol-induced intracochlear pressure alterations in hydropic ears, but do not occur in patients without Meniere's disease. " 05/01/2013 - "Selection was made among 38 patients with Meniere's disease for those having positive glycerol test. " 05/01/2013 - "Dynamics of pure tone audiometry and DPOAE changes induced by glycerol in Meniere's disease." 10/01/2012 - "[Comparison of the diagnostic value of 3 T MRI after intratympanic injection of GBCA, electrocochleography, and the glycerol test in patients with Meniere's disease]."
3.	Dexamethasone (Maxidex)FDA LinkGeneric 01/01/2005 - "To compare the efficacy of conventional medical treatment versus transtympanic dexamethasone application into middle ear as treatment modality in Meniere's disease. " 05/01/2014 - "The study showed results of intratympanic perfusion therapy with dexamethasone in patients with retractable Meniere's disease who are resistant to conservative treatment. " 03/01/1998 - "Dexamethasone inner ear perfusion for the treatment of Meniere's disease: a prospective, randomized, double-blind, crossover trial." 01/01/2015 - "Together, our results demonstrate that intratympanic dexamethasone injection, as an effective therapeutic strategy for refractory Meniere's disease, could either be used for cascade therapy preoperation or used for patients who couldn't accept the surgery. " 05/01/2014 - "Single doses of 4 mg/ml dexamethasone were given intratympanically in 19 patients with retractable Meniere's disease. "
4.	Betahistine (Serc)IBA 01/01/1991 - "From clinical studies, it appears that betahistine is an effective agent for the symptomatic treatment of Meniere's syndrome. " 09/01/1976 - "The management of Meniere's disease with betahistine can be regarded as an improvement in the conservative therapy of this disorder." 01/01/1991 - "Betahistine is the current most effective drug in maintenance therapy of Meniere's disease, although it does not resolve all of the problem of this disorder. " 05/01/1985 - "[Treatment of Meniere disease with betahistine dimesilate (Aequamen)--double-blind study versus placebo (crossover)]." 12/01/1978 - "[Management of Meniere's disease using betahistine]."
5.	Urea (Carbamide)FDA LinkGeneric 01/01/1984 - "Urea (9 g a day) is a very useful drug in the treatment of Meniere's disease. " 09/01/1979 - "The results of the present study seem to render partial explanation of improved hearing in patients with Meniere's disease who were treated with urea." 01/01/2014 - "Oral urea has been used in the past to treat various diseases like gastric ulcers, liver metastases, sickle cell disease, heart failure, brain oedema, glaucoma, Meniere disease, etc. We have demonstrated for years, the efficacy of urea to treat euvolemic (SIADH) or hypervolemic hyponatremia. " 05/01/1986 - "A study of patients with Meniere's disease was designed to compare the effectiveness of glycerol versus urea in inducing a temporary improvement in hearing thresholds. " 03/01/1983 - "A mathematical-statistical analysis of the role of glycerin and urea tests in patients with Meniere's disease is presented. "
6.	Streptomycin (Streptomycin Sulfate)FDA Link 08/01/1984 - "Great caution and supervision should be exercised in the use of streptomycin titration therapy in the individual with bilateral Meniere's disease, as further experience is required to determine the efficacy of this form of management." 02/01/1998 - "At the Gruppo Otologico, Piacenza, Italy, between 1987 and 1995 we treated 16 patients with either bilateral Meniere's disease or with Meniere's disease in their only hearing ear, adopting the titration streptomycin therapy protocol of Graham et al. Three patients with follow-up periods of less than 2 years were not included in this study. " 01/01/2001 - "The ablation treatment of Meniere's disease by intratympanic streptomycin applications was first reported by Schuknecht in 1957. " 10/01/2000 - "To investigate the clinical effect of streptomycin perfusion of the labyrinth (SPL) in the treatment of Meniere's disease. " 02/01/1998 - "Titration streptomycin therapy in Meniere's disease: long-term results."
7.	SteroidsIBA 05/01/2008 - "Effects of endolymphatic sac drainage with steroids for intractable Meniere's disease: a long-term follow-up and randomized controlled study." 07/01/2015 - "Effects of posterior tympanotomy with steroids at round window on hearing recovery after revision surgery for intractable Meniere's disease." 10/01/2013 - "Long-term results of endolymphatic sac drainage with local steroids for intractable Meniere's disease." 05/01/2008 - "Since Meniere's disease is thought to be triggered by an immune insult to the inner ear, we examined intraendolymphatic sac application of steroids as a new therapeutic strategy for intractable Meniere's disease. " 09/01/2002 - "Although steroid treatment is generally administered for patients with inner ear disorders, including Meniere's disease, the mechanism via which steroids exert their effects remains to be clarified. "
8.	Lidocaine (Xylocaine)FDA LinkGeneric 09/01/1976 - "The effect of xylocaine on epileptic attacks suggested a study of its effect in attacks on Meniere's disease, as the symptoms can be very much alike in the two conditions. " 12/01/1985 - "Lidocaine in the treatment of Meniere's disease." 08/01/1985 - "Treatment of Meniere's disease by intratympanic injection with lidocaine." 09/01/1976 - "Intravenous xylocaine in the treatment of attacks on Meniere's disease." 01/01/1999 - "Intravenous lidocaine has been reported to alleviate vertigo in Meniere's disease and suggested as a possible antivertigo agent after unilateral labyrinthectomy in a study of cats. "
9.	AntigensIBA 05/01/2001 - "Further study is required for elucidating the role of these antigens in the pathogenesis of Meniere's disease, which might eventually result in better therapy." 01/01/2014 - "Enhanced immune reactions with 18 candidate antigens were detected in patients with Meniere's disease in Protoarray analysis; levels of 8 of these antigens were more than 10-fold higher in patients than in controls. " 08/01/2012 - "The immune response in Meniere's disease is focused on inner ear antigens. " 08/01/2008 - "To investigate the main components of inner ear antigens inducing autoimmune Meniere's disease (AIMD) in guinea pigs. " 08/01/2008 - "[Analysis of the main components of inner ear antigens inducing autoimmune Meniere's disease in guinea pigs]."
10.	GadoliniumIBA 01/01/2015 - "The aim of the study is to probe whether intratympanically gadolinium contrast-enhanced three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging, together with magnetic resonance imaging scoring system of the perilymphatic space, had advantages in diagnosing patients with bilateral Meniere's disease. " 08/01/2013 - "To study the feasibility of endolymphatic visualization and the diagnosis of Meniere's disease by applying intratympanic gadolinium administration through the tympanic membrance and three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI). " 01/01/2015 - "Diagnostic advantages of intratympanically gadolinium contrast-enhanced magnetic resonance imaging in patients with bilateral Meniere's disease." 08/01/2013 - "With a three Tesla magnetic resonance imaging (MRI) unit, 3D-FLAIR imaging was performed 24 hours after intratympanic gadolinium through the tympanic membrance in 32 patients with clinically diagnosed unilateral Meniere's Disease. " 12/13/2011 - "[Diagnostic value and clinical application of inner ear imaging after an intratympanic injection of gadolinium for Meniere's disease]."

Therapies and Procedures

1.	Decompression 08/01/2005 - "Endolymphatic sac decompression significantly improved perception of physical health, as well as symptom-specific outcomes, in patients with medically intractable Meniere's disease." 04/01/2003 - "The beneficial long-term outcome of the endolymphatic sac-vein decompression supports its continued use as a first-line treatment option in intractable Meniere's disease." 11/01/2009 - "To investigate the efficacy of endolymphatic sac surgery for Meniere's disease, and compare the effects of endolymphatic sac decompression with endolymphatic-mastoid shunting. " 04/01/2003 - "We sought to determine the long-term efficacy of endolymphatic sac-vein decompression surgery on patients with classic Meniere's disease. " 07/01/1987 - "This study demonstrates the superiority of a valved implant (Denver-Arenberg valve) over simple sac decompression surgery for Meniere's disease. "
2.	Injections 03/01/2003 - "Ending weekly intratympanic injections when clinical signs of vestibular deafferentation appear can control vertigo in the majority of patients, and it is a useful alternative, together with other surgical options, for the treatment of patients with Meniere's disease who do not respond to medical treatment." 08/01/2005 - "To investigate the efficacy of intratympanic dexamethasone injections (IDI) and intermittent pressure (IP) for 13 patients with intractable Meniere's disease (MD). " 07/01/2004 - "To investigate the efficacy of intratympanic dexamethasone injections (IDI) for 15 patients with intractable Meniere's disease (MD). " 07/01/2006 - "The present study is a prospective study of 8 patients in Ramathibodi Hospital who had transtympanic gentamicin treatment of Meniere's disease by fixed dose regimen of 12 injections during a period of 4 days. " 01/01/2005 - "The aim of this study is to analyze the effects of intratympanic gentamicin injections on vestibular function in 33 patients with unilateral Meniere's Disease (according to AAO-HNS guidelines 1995) that had been unresponsive to medical therapy for at least one year. "
3.	Oral Administration 08/01/2001 - "vestibular evoked myogenic potentials in some patients with unilateral Meniere's disease were improved by oral administration of glycerol. " 06/01/2001 - "Transiently evoked OAE (TEOAE) and distortion product OAE (DPOAE) were measured before and 3 hours after oral administration of glycerol in 22 ears of patients with Meniere's disease. " 01/01/1984 - "In the diagnosis of Meniere's disease, oral administration of glycerol is more effective than intravenous injection."
4.	Tenotomy 12/01/2015 - "This study aims to compare the outcomes of patients with Meniere's disease submitted to either endolymphatic mastoid shunt (ES) or tenotomy of the stapedius and tensor tympani muscles (TSTM). " 05/01/2012 - "This study compares the unique long-term results of tenotomy of the stapedius and tensor tympani muscles in definite Meniere's disease refractory to medical treatment and presents a hypothesis on why tenotomy seems effective. " 12/01/2015 - "Endolymphatic sac surgery versus tenotomy of the stapedius and tensor tympani muscles in the management of patients with unilateral definite Meniere's disease." 04/01/2013 - "A retrospective follow-up study of 42 patients with definite, unilateral Meniere's disease (19 males, 23 females, average age = 58.1 ± 14.1 years) had undergone tenotomy under general anesthesia through an endaural approach. " 05/01/2012 - "Because the presented data reveal an immediate and persistent reduction of vertigo and a clear improvement in hearing function and functional scales, we conclude tenotomy to be effective in unilateral, definite Meniere's disease - laying the foundation for future prospective, randomized controlled trials. "
5.	Electrodes (Electrode) 04/01/1991 - "Recent advances in electrode design have helped to rekindle clinical interests in noninvasive electrocochleography--to enhance auditory brain stem response (ABR) recordings (namely, wave I) and to screen Meniere's disease. " 01/01/2000 - "In this study, eight adults (16 ears) with suspected Meniere's disease were examined using a newly designed, disposable tympanic electrode and a traditional, thin transtympanic needle. " 06/01/1989 - "The purpose of the present study was to evaluate ECoG recordings obtained simultaneously from a transtympanic electrode and a tympanic membrane electrode in 26 patients with unilateral Meniere's disease. "