Melorheostosis

07/01/1986 - "Successful symptomatic treatment of melorheostosis with nifedipine."
07/01/1986 - "We describe a patient with melorheostosis who showed improvement in pain and vasomotor function after treatment with nifedipine. "

03/01/2009 - "Report a new case of melorheostosis of the ribs improved by pamidronate infusions A 36-year-old man without any medical history was admitted for a history of one month painful tumefaction on the 7th left rib. "
03/01/2009 - "Atypical form of melorheostosis improved by pamidronate."

08/01/2007 - "Recent studies have reported loss of function mutations in the LEMD3 gene, encoding an inner nuclear membrane protein that influences Smad signaling, as a cause of osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis. "
09/01/2015 - "Novel Somatic Mutation in LEMD3 Splice Site Results in Buschke-Ollendorff Syndrome with Polyostotic Melorheostosis and Osteopoikilosis."
06/01/2009 - "Mutations in the LEMD3 gene were recently incriminated in Buschke-Ollendorff syndrome (BOS) and osteopoikilosis, with or without melorheostosis. "
06/01/2009 - "Novel and recurrent germline LEMD3 mutations causing Buschke-Ollendorff syndrome and osteopoikilosis but not isolated melorheostosis."
02/01/2007 - "Deactivating germline mutations in LEMD3 cause osteopoikilosis and Buschke-Ollendorff syndrome, but not sporadic melorheostosis."

01/01/1976 - "Letter: Mixed sclerosing bone dystrophy with regression of melorheostosis."
05/01/1975 - "Mixed sclerosing bone dystrophy with regression of melorheostosis."
03/01/1986 - "We present a detailed metabolic investigation and 42-year radiological follow-up of a 52-year-old man with mixed-sclerosing-bone-dystrophy, the rare occurrence of two or more distinct patterns of sclerosing-bone-dysplasia (e.g., osteopathia striata, osteopoikilosis, melorheostosis) in a single subject. "

06/01/2009 - "The search for mutations in DNA extracted from the peripheral blood, as well as skin and bone biopsies of the patient with melorheostosis failed to identify any pathogenic change. "
08/01/2007 - "Perhaps unsurprisingly in what is a segmental disease, we did not find LEMD3 mutations in peripheral-blood-derived DNA from the two other individuals with sporadic melorheostosis. "

01/01/2014 - "This systematic review explored current literature on therapeutic directions for the following rare genetic bone disorders: fibrous dysplasia, Gorham-Stout syndrome, fibrodysplasia ossificans progressiva, melorheostosis, multiple hereditary exostosis, osteogenesis imperfecta, craniometaphyseal dysplasia, achondroplasia, and hypophosphatasia. "
01/01/1991 - "The list of conditions constituting this group is relatively short: osteopetrosis (Albers-Schönberg disease), pycnodysostosis (Maroteaux-Lamy disease), enostosis (bone island), osteopoikilosis, osteopathia striata (Voorhoeve disease), progressive diaphyseal dysplasia (Camurati-Engelmann disease), hereditary multiple diaphyseal sclerosis (Ribbing disease), four types of endosteal hyperostosis (van Buchem disease, Worth disease, Nakamura disease, and Truswell-Hansen disease), dysosteosclerosis, metaphyseal dysplasia (Pyle's disease), craniometaphyseal dysplasia, melorheostosis (Leri disease), and craniodiaphyseal dysplasia. "

01/01/2010 - "We report a case of melorheostosis, a rare bone disorder characterised by mesodermal dysplasia, and its successful and prolonged treatment with the intravenous bisphosphonate zoledronic acid. "
01/01/2010 - "Melorheostosis and its treatment with intravenous zoledronic acid."
01/01/2013 - "We report an adult patient with a very painful melorheostosis, who  improved after treatment with zoledronate, either on symptoms or on bone scans. "
01/01/2013 - "Successful treatment of pain in melorheostosis with zoledronate, with improvement on bone scintigraphy."
01/01/2010 - "We suggest that melorheostosis can be treated with intravenous zoledronic acid and that treatment can be monitored by the use of a specific bone resorption marker."

03/01/2000 - "A TGF-beta-inducible cell adhesion molecule, betaig-h3, is downregulated in melorheostosis and involved in osteogenesis."

03/01/2001 - "These cytokines may have some association with the exuberant bone matrix production and angiogenesis in melorheostosis."

04/01/2003 - "Increased procollagen alpha1(I) mRNA expression by dermal fibroblasts in melorheostosis."
04/01/2003 - "We report a patient with melorheostosis in whom increased procollagen alpha1(I) mRNA expression and alpha1(I), alpha2(I) and alpha1(III) collagen secretion were observed in dermal fibroblasts obtained from a skin biopsy overlying the involved bone. "

01/01/2013 - "We report an adult patient with a very painful melorheostosis, who  improved after treatment with zoledronate, either on symptoms or on bone scans. "
07/01/1986 - "We describe a patient with melorheostosis who showed improvement in pain and vasomotor function after treatment with nifedipine. "

02/01/1963 - "[Hip osteotomy in the melorheostosis patient]."
08/01/1992 - "Traditional conservative and surgical methods of treatment of melorheostosis, such as manipulations, plaster casts, soft-tissue releases, capsulotomies, and osteotomies cause a high recurrence rate. "
09/01/2003 - "A 14-year, 2-month-old boy, who presented with a recurrent equinoplanovalgus deformity of the right foot caused by melorheostosis, was treated successfully using the Ilizarov technique, including distraction osteotomy in the calcaneus. "

04/01/2014 - "This case highlights the role of nerve decompression in melorheostosis and the importance of early identification of the disease to prevent unnecessary bone biopsies. "
08/01/2013 - "We report a case of lumbar melorheostosis causing disabling radiculopathy treated with nerve root decompression. "

04/01/2005 - "Melorheostosis--an unusual cause of amputation."
09/01/2000 - "We present a case of melorheostosis in the lower extremity of a 20-year-old woman for which detailed radiologic- pathologic correlation was achieved due to amputation of the involved limb."

09/01/2003 - "A 14-year, 2-month-old boy, who presented with a recurrent equinoplanovalgus deformity of the right foot caused by melorheostosis, was treated successfully using the Ilizarov technique, including distraction osteotomy in the calcaneus. "