Melkersson-Rosenthal Syndrome

An idiopathic syndrome characterized by one or more of the following; recurrent orofacial swelling, relapsing facial paralysis, and fissured tongue (lingua plicata). The onset is usually in childhood and relapses are common. Cheilitis granulomatosa is a monosymptomatic variant of this condition. (Dermatol Clin 1996 Apr;14(2):371-9; Magalini & Magalini, Dictionary of Medical Syndromes, 4th ed, p531)
Also Known As:
Cheilitis Granulomatosa; Cheilitis Granulomatosa, Orofacial Edema, Facial Neuropathy; Facial Neuropathy, Cheilitis Granulomatosa, Orofacial Edema; Facial Neuropathy, Orofacial Edema, Cheilitis Granulomatosa; Macrocheilia, Facial Palsy, Edema; Melkerson-Rosenthal Syndrome; Melkersson Syndrome; Melkersson-Rosenthal-Miescher Syndrome; Miescher-Melkersson-Rosenthal Granulomatous Cheilitis; Orofacial Edema, Cheilitis Granulomatosa, Facial Neuropathy; Orofacial Edema, Facial Neuropathy, Cheilitis Granulomatosa; Rosenthal-Melkerson Syndrome; Rosenthal-Melkersson Syndrome; Syndrome, Melkerson Rosenthal; Cheilitis, Miescher-Melkersson-Rosenthal Granulomatous; Granulomatous Cheilitis, Miescher-Melkersson-Rosenthal; Melkerson Rosenthal Syndrome; Melkersson Rosenthal Miescher Syndrome; Melkersson Rosenthal Syndrome; Miescher Melkersson Rosenthal Granulomatous Cheilitis; Rosenthal Melkerson Syndrome; Rosenthal Melkersson Syndrome; Cheilitis Granulomatosa, Facial Neuropathy, Orofacial Edema; Granulomatous Cheilitis
Networked: 85 relevant articles (8 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Cheilitis
2. Cutaneous Leishmaniasis
3. Necrosis
4. Blepharitis
5. Melkersson-Rosenthal Syndrome


1. Imafuku, Shinichi: 1 article (06/2015)
2. Koga, Monji: 1 article (06/2015)
3. Tatsukawa, Ryoko: 1 article (06/2015)
4. Koga, Kaori: 1 article (06/2015)
5. Tan, Zulin: 1 article (05/2015)
6. Coggi, Antonella: 1 article (05/2015)
7. Muratori, Simona: 1 article (05/2015)
8. Carrera, Carlo Giovanni: 1 article (05/2015)
9. Chen, Wei: 1 article (05/2015)
10. Xu, Xianrong: 1 article (05/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Melkersson-Rosenthal Syndrome:
1. Clofazimine (Lamprene)FDA Link
2. SteroidsIBA
3. Adrenal Cortex Hormones (Corticosteroids)IBA
4. adalimumab (Humira)FDA Link
5. Histamine Antagonists (Antihistamines)IBA
6. tranilast (N 5')IBA
7. Fluconazole (Zonal)FDA LinkGeneric
8. Sulfasalazine (Azulfidine)FDA LinkGeneric
9. LymecyclineIBA
10. FumaratesIBA

Therapies and Procedures

1. Intralesional Injections
2. Decompression
3. Injections
4. Oral Medicine
5. Lasers (Laser)