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Mefenamic Acid (Pontal)

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A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.

Also Known As:

Pontal; APS Brand of Mefenamic Acid; Antigen Brand of Mefenamic Acid; Apo-Mefenamic; Apotex Brand of Mefenamic Acid; Ashbourne Brand of Mefenamic Acid; Chemidex Brand of Mefenamic Acid; Clonmel Brand of Mefenamic Acid; Contraflam; Coslan; Dysman; Elan Brand of Mefenamic Acid; Farmasierra Brand of Mefenamic Acid; First Horizon Brand of Mefenamic Acid; Gödecke Brand of Mefenamic Acid; Mefac; Mefacit; Mefenaminic Acid; Mefic; Nu-Mefenamic; Nu-Pharm Brand of Mefenamic Acid; PMS-Mefenamic Acid; Parke Davis Brand of Mefenamic Acid; Parkemed; Pfizer Brand of Mefenamic Acid; Pharmascience Brand of Mefenamic Acid; Pinalgesic; Pinewood Brand of Mefenamic Acid; Ponalar; Ponalgic; Ponmel; Ponstan; Ponstan Forte; Ponstel; Ponsyl; Rowa Brand of Mefenamic Acid; Warner-Lambert Brand of Mefenamic Acid; Acid, Mefenamic; Acid, Mefenaminic; Apo Mefenamic; ApoMefenamic; Forte, Ponstan; Nu Mefenamic; Nu Pharm Brand of Mefenamic Acid; NuMefenamic; PMS Mefenamic Acid; Warner Lambert Brand of Mefenamic Acid; Benzoic acid, 2-((2,3-dimethylphenyl)amino)-

Networked: 298 relevant articles (32 outcomes, 51 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Carboxylic Acids: 83
  - Carbocyclic Acids
    - Benzoic Acids: 18
      - Aminobenzoic Acids
        Anthranilic Acids: 3
        Fenamates: 13
        Mefenamic Acid: 298
        1-O-(2-(2,3-dimethylphenyl)aminobenzoyl)glucopyranuronic acid
        1-O-(2-(3-carboxy-2-methylphenyl)aminobenzoyl)glucopyranuronic acid
        1-O-(2-(3-hydroxymethyl-2-methylphenyl)aminobenzoyl)glucopyranuronic acid
        mefenamic acid diethylaminoethyl ester
        mefenamic acid glutathione thioester

Experts

1.	Bhat, Abdul-Shakoor: 3 articles (03/2008 - 03/2005)
2.	Krishna, Vamsi: 3 articles (03/2008 - 03/2005)
3.	Kumar, Dinesh: 3 articles (03/2008 - 03/2005)
4.	Prakash, Vellanki Ravi: 3 articles (03/2008 - 03/2005)
5.	Tandan, Surendra Kumar: 3 articles (03/2008 - 03/2005)
6.	Vermeulen, Nico P E: 2 articles (12/2014 - 04/2014)
7.	Venkataraman, Harini: 2 articles (12/2014 - 04/2014)
8.	Commandeur, Jan N M: 2 articles (12/2014 - 04/2014)
9.	Prestes-Carneiro, Luiz Euribel: 2 articles (03/2013 - 02/2006)
10.	Tanmahasamut, Prasong: 2 articles (09/2012 - 08/2012)

Related Diseases

1.	Pain (Aches) 01/01/1980 - "Analysis of data from 87 patients showed that mefenamic acid was equally effective in relieving pain and was less likely to produce adverse side-effects." 05/01/2006 - "A study in Kerman, Islamic Republic of Iran in 2002 compared the effectiveness of fennel and mefenamic acid on pain relief in primary dysmenorrhoea. " 01/01/2015 - "The pain score was increased with mefenamic acid (P = 0.003), which was significant on VAS. " 01/01/2011 - "The NNT for at least 50% pain relief over 6 hours with a single dose of mefenamic acid 500 mg compared to placebo was 4.0 (2.7 to 7.1), and the NNT to prevent use of rescue medication over 6 hours was 6.5 (3.6 to 29). " 05/01/2006 - "In the fennel group, 80% of girls and in the mefenamic acid group, 73% of girls showed complete pain relief or pain decrease, while 80% in the fennel group and 62% in the mefenamic acid group no longer needed to rest. "
2.	Dysmenorrhea (Menstrual Pain) 01/01/1980 - "It is concluded that the mefenamic acid is safe and effective in most patients for the relief of primary dysmenorrhea and represents a rational short-term therapy for this syndrome." 02/01/2003 - "The essence of fennel can be used as a safe and effective herbal drug for primary dysmenorrhea, however, it may have a lower potency than mefenamic acid in the dosages used for this study." 11/01/2014 - "Comparative evaluation of the efficacy of herbal drugs (fennelin and vitagnus) and mefenamic acid in the treatment of primary dysmenorrhea." 11/01/2014 - "The aim of this study was to compare the effects of herbal products (fennelin and vitagnus) and mefenamic acid in the treatment of primary dysmenorrhea. " 04/01/2014 - "The aim of this study was to assess the effect of Dill compared to mefenamic acid on primary dysmenorrhea. "
3.	Menorrhagia 09/01/1990 - "A well controlled double blind prospective trial was undertaken to determine the efficacy of mefenamic acid in the treatment of menorrhagia. " 02/01/1983 - "Clinical trial of the efficacy of mefenamic acid in relief of menorrhagia and/or dysmenorrhoea." 11/01/1981 - "Efficacy of mefenamic acid in patients with a complaint of menorrhagia." 11/01/1981 - "Sixty-nine patients with a convincing history of menorrhagia completed a 4-cycle double-blind randomized placebo-controlled crossover trial of mefenamic acid taken during menstruation. " 05/01/1980 - "Studies in menorrhagia: (a) mefenamic acid, (b) endometrial prostaglandin concentrations."
4.	Hemorrhage 11/01/1986 - "Women with leiomyomata almost always exhibited large volumes of menstrual bleeding, which was invariably reduced by myomectomy and sometimes helped by mefenamic acid. " 09/01/2013 - "This study aimed to compare the effect of mefenamic acid and vitex agnus castus on IUD induced bleeding. " 09/01/2013 - "Mefenamic acid and vitex agnus were both effective on IUD induced bleeding; however, mefenamic acid was more effective." 09/01/2013 - "In the mefenamic acid group, the decreased bleeding was significantly more than the vitex agnus group. " 09/01/2013 - "Mefenamic acid and vitex agnus significantly decreased bleeding. "
5.	Migraine Disorders (Migraine) 04/19/2000 - "It might be concluded that mefenamic acid is safe and effective for treatment of acute menstrual migraine." 04/19/2000 - "Treatment of menstrual migraine with prostaglandin synthesis inhibitor mefenamic acid: double-blind study with placebo." 05/01/1986 - "The study suggests that mefenamic acid and propranolol are equally effective for migraine prophylaxis." 05/01/1986 - "There were no significant effects of mefenamic acid or propranolol on average duration or severity of migraine attacks. " 05/01/1986 - "The prophylactic effects of the antiprostaglandin agent mefenamic acid on migraine attacks were compared with propranolol or placebo in a double-blind crossover study of 29 patients. "

Related Drugs and Biologics

1.	Aspirin (Acetylsalicylic Acid)
2.	Ibuprofen (Motrin)
3.	nimesulide (Aulin)
4.	Acetaminophen (Paracetamol)
5.	Tranexamic Acid (AMCA)
6.	Norethindrone (Norethisterone)
7.	Levonorgestrel (Plan B)
8.	Diclofenac (SR 38)
9.	Naproxen (Naprosyn)
10.	Ketoprofen (Orudis)

Related Therapies and Procedures

1.	Obstetrical Anesthesia
2.	Aftercare (After-Treatment)
3.	Light Coagulation
4.	Curettage
5.	Oral Surgery (Maxillofacial Surgery)