Medrogestone

6,17-Dimethylpregna-4,6-diene-3,20-dione. A synthetic progestational hormone with actions similar to those of progesterone. It is used in the treatment of menstrual irregularities and has also been employed in the treatment of prostatic hypertrophy and endometrial carcinoma.

Also Known As:

Networked: 26 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pasqualini, Jorge R: 3 articles (12/2009 - 10/2007)
2.	Ebert, C: 2 articles (12/2001 - 12/2001)
3.	Becker, S: 1 article (12/2018)
4.	Cezar, T C: 1 article (12/2018)
5.	De Wilde, R L: 1 article (12/2018)
6.	Krentel, H: 1 article (12/2018)
7.	Pletzer, K R: 1 article (12/2018)
8.	Schweppe, K W: 1 article (12/2018)
9.	Torres-De La Roche, L A: 1 article (12/2018)
10.	Pasqualini, Jorge Raul: 1 article (02/2009)

Related Diseases

1.	Mastodynia 12/01/2001 - "Cyclic administration of the low-dose progestins medrogestone and dydrogesterone proved to be an effective and safe treatment of mastodynia and mastopathy. " 12/01/2001 - "In a controlled, randomized, double-blind, parallel-group study we treated 31 women with mastopathy/mastodynia with the progestins medrogestone (10 mg/day) or dydrogesterone (10 mg/day) from day 14 to day 25 for six cycles. "
2.	Mood Disorders (Mood Disorder) 02/01/1996 - "With the exception of vertigo, mood depression, mood disorder, loss of libido, and dryness of skin, where tibolone was found to be more effective than conjugated estrogens/medrogestone, climacteric symptoms improved significantly in both groups over the 6-month study period. "
3.	Vertigo (Positional Vertigo) 02/01/1996 - "With the exception of vertigo, mood depression, mood disorder, loss of libido, and dryness of skin, where tibolone was found to be more effective than conjugated estrogens/medrogestone, climacteric symptoms improved significantly in both groups over the 6-month study period. "
4.	Breast Neoplasms (Breast Cancer) 09/01/1972 - "Disseminated breast cancer: evaluation of hormonal therapy utilizing stilbestrol and medrogestone (AY-62022) singly and in combination." 01/01/1999 - "It is concluded that the inhibition provoked by Medrogestone on the reductive 17beta-HSD activity involved in the local biosynthesis of the biologically active estrogen estradiol, may constitute a new therapeutic approach for the treatment of breast cancer." 01/01/1999 - "Effect of Medrogestone on 17beta-hydroxysteroid dehydrogenase activity in the hormone-dependent MCF-7 and T-47D human breast cancer cell lines." 07/01/1999 - "Control of sulfatase and sulfotransferase activities by medrogestone in the hormone-dependent MCF-7 and T-47D human breast cancer cell lines." 07/01/1999 - "In the present study, we explored the effect of the progestin medrogestone on the sulfatase and sulfotransferase activities in the hormone-dependent MCF-7 and T-47D human breast cancer cell lines. "
5.	Hemorrhage 09/01/1996 - "Four medrogestone-treated patients dropped out due to unscheduled bleeding. " 09/01/1996 - "A low dose of medrogestone added to transdermal estradiol induced incomplete transformation of endometrium and oligo-amenorrhea more frequently than MPA, but it increased the chances of irregular bleeding. " 12/10/2002 - "Bleeding patterns in peri and postmenopausal women taking a continuous combined regimen of estradiol with norethisterone acetate or a conventional sequential regimen of conjugated equine estrogens with medrogestone." 12/10/2002 - "The aim of this study was to compare the incidence of women presenting irregular bleeding episodes following 9 months of treatment with a low dose continuous combined hormone replacement therapy consisting of estradiol (E(2)) and norethisterone acetate (NETA) versus a sequential hormone replacement therapy consisting of conjugated equine estrogens (CEE) and medrogestone (MG). " 09/01/1996 - "We evaluated bleeding pattern and endometrium following the administration of two of the most common types of progestogens used in hormone replacement therapy, medroxyprogesterone acetate (MPA) and medrogestone acetate. "

Related Drugs and Biologics

1.	Conjugated (USP) Estrogens (Premarin)
2.	Progestins (Progestagens)
3.	tibolone
4.	Dydrogesterone
5.	Medrogestone
6.	Hormones (Hormone)
7.	Sulfatases
8.	Estradiol (Delestrogen)
9.	Sulfotransferases
10.	Minerals

Related Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
2.	Therapeutics
3.	Glycemic Control