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Mechlorethamine (Nitrogen Mustard)

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A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage.

Also Known As:

Nitrogen Mustard; Chlormethine; Mustargen; Mustine; Bis(2-chloroethyl)methylamine; Caryolysine; Cloramin; Embichin; Genopharm Brand of Mechlorethamine Hydrochloride; Mechlorethamine Hydrochloride; Mechlorethamine Hydrochloride N-Oxide; Mechlorethamine N-Oxide; Merck Brand of Mechlorethamine Hydrochloride; Merck Frosst Brand of Mechlorethamine Hydrochloride; Methylchlorethamine; Mitomen; NSC-10107; NSC-762; Nitrogranulogen; Nitromin; Hydrochloride N-Oxide, Mechlorethamine; Hydrochloride, Mechlorethamine; Mechlorethamine Hydrochloride N Oxide; Mechlorethamine N Oxide; N-Oxide, Mechlorethamine; N-Oxide, Mechlorethamine Hydrochloride; N-Oxide, Nitrogen Mustard; NSC 10107; NSC 762; NSC10107; NSC762; Nitrogen Mustard N Oxide; Oxide, Mechlorethamine; Chlorethazine; Mechlorethamine Oxide; Nitrogen Mustard N-Oxide; Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-

Networked: 1446 relevant articles (66 outcomes, 128 trials/studies)

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Drug Context: Research Results

Experts

1.	Wilson, William R: 6 articles (09/2015 - 04/2003)
2.	Laskin, Jeffrey D: 5 articles (12/2015 - 01/2011)
3.	Laskin, Debra L: 5 articles (12/2015 - 01/2011)
4.	Agarwal, Rajesh: 5 articles (05/2015 - 10/2012)
5.	Tewari-Singh, Neera: 5 articles (05/2015 - 10/2012)
6.	Inturi, Swetha: 5 articles (05/2015 - 10/2012)
7.	Jain, Anil K: 5 articles (05/2015 - 10/2012)
8.	Duvic, Madeleine: 5 articles (01/2015 - 03/2003)
9.	Malaviya, Rama: 4 articles (12/2015 - 12/2012)
10.	Gow, Andrew J: 4 articles (12/2015 - 01/2011)

Related Diseases

1.	Hodgkin Disease (Hodgkin's Disease) 10/01/1970 - "Long-term remission in Hodgkin's disease after nitrogen mustard therapy." 11/01/1959 - "[Clinical studies on nitrogen mustard and roentgen therapy of Hodgkin's disease]." 05/01/1998 - "[Hodgkin's disease in two children of mother treated with nitrogranulogen]." 12/01/1992 - "Four patients with fresh Hodgkin's disease were treated with MOPP/ABV hybrid regimen using nitrogen mustard-N-oxide hydrochloride (NH2-O). " 12/01/1992 - "[Four cases of Hodgkin's disease treated with MOPP/ABV hybrid regimen using nitrogen mustard-N-oxide hydrochloride]."
2.	Neoplasms (Cancer) 03/24/1955 - "The palliation and remission of cancer with combined corticosteroid and nitrogen mustard therapy; a report of 100 cases." 09/01/1979 - "Combined nitrogen mustard--radiation studies with a mouse tumor." 11/01/1965 - "A study on immunological therapy for cancer by using nitrogen mustard-treated cancer tissue." 01/01/1964 - "[STUDIES ON THE EFFECT OF NEW NITROGEN MUSTARD ANALOGES ON NK/LY TRANSPLANTABLE TUMORS]." 06/01/1961 - "Studies on the metabolism of ratascites-tumors with nitrogen mustard sensitive and resistant strains. "
3.	Mycosis Fungoides 01/01/2013 - "The use of a novel mechlorethamine, 0.02%, gel in the treatment of patients with mycosis fungoides is effective and safe. " 03/15/1999 - "To compare the efficacy of total skin electron beam therapy (TSEBT) with or without adjuvant topical nitrogen mustard (+/- HN2) with topical nitrogen mustard (HN2) alone as initial management of T2 and T3 mycosis fungoides (MF). " 01/01/1983 - "Remission of lesions in mycosis fungoides following topical application of nitrogen mustard. " 07/01/1980 - "In 10 patients with mycosis fungoides (MF) who were in clinical remission following local treatment with nitrogen mustard, cell-mediated immunity was investigated by means of tests for lymphocytes, forming rosettes in the peripheral blood, and the graft-vs-host reaction as well as intradermal skin tests. " 12/01/1968 - "In the present study, topically applied nitrogen mustard solution was used to control recurrences of mycosis fungoides following electron beam therapy in 11 patients. "
4.	Lymphoma (Lymphomas) 11/01/2002 - "Mechlorethamine is frequently used in the treatment of cutaneous lymphoma, but its application is limited in 30-80% of cases because of cutaneous intolerance. " 05/01/1997 - "A 21-year-old woman with malignant lymphoma received a large dose of nitrogen mustard followed by autologous bone marrow. " 01/01/1958 - "Antitumor effects of homologous immune serum, immune lymphocytes and nitrogen mustard against a rat lymphoma." 11/14/1953 - "[Nitrogen mustard gas therapy of tuberculous lymphoma]." 06/01/1953 - "The use of nitrogen mustard in the management of two pregnant lymphoma patients."
5.	Leukemia 05/01/1951 - "[Therapeutic efficacy of nitrogen mustard in a case of chronic lymphatic leukemia with diffuse cutaneous leukemia]." 01/01/2006 - "Therapeutic targets in the nitrogen mustard sensitivity of B-cell chronic lymphocyte leukemia (B-CLL)." 05/01/1994 - "The cumulative dose of mechlorethamine was the most important factor in determining leukemia risk. " 01/01/1989 - "The 10-year cumulative incidence of leukemia was zero in patients treated with limited RT alone, 2.4% in those treated with extended RT alone, 0% in those treated with a combination of RT and CT without nitrogen mustard, and 12.4% in those treated with RT + nitrogen mustard. " 01/01/1989 - "A dose response was observed, with the risk relative to general population incidence rates being 45 in patients having been treated with 1-59 mg (total dose) of nitrogen mustard, 211 in those treated with 60-119 mg, and 636 in those treated with greater than or equal to 120 mg. No other factors were found to be associated with leukemia risk. "

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Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Laparotomy