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Mastoiditis

Inflammation of the honeycomb-like MASTOID BONE in the skull just behind the ear. It is usually a complication of OTITIS MEDIA.
Also Known As:
Mastoiditides
Networked: 468 relevant articles (19 outcomes, 28 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Otitis Media
2. Sepsis (Septicemia)
3. Abscess
4. Sinusitis
5. Meningitis

Experts

1. Leibovitz, Eugene: 5 articles (08/2022 - 12/2008)
2. Hermansson, Ann: 4 articles (07/2015 - 12/2010)
3. Stenfeldt, Karin: 4 articles (07/2015 - 12/2010)
4. Kaplan, Daniel M: 3 articles (08/2022 - 10/2014)
5. Drela, Maria: 3 articles (11/2019 - 08/2018)
6. Haber, Karolina: 3 articles (11/2019 - 08/2018)
7. Mierzwiński, Józef: 3 articles (11/2019 - 08/2018)
8. Puricelli, Michael David: 3 articles (11/2019 - 08/2018)
9. Sinkiewicz, Anna: 3 articles (11/2019 - 08/2018)
10. Tyra, Justyna: 3 articles (11/2019 - 08/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mastoiditis:
1. Anti-Bacterial Agents (Antibiotics)IBA
2. Penicillins (Penicillin)FDA Link
3. Streptomycin (Streptomycin Sulfate)FDA Link
4. Sulfadiazine (Sulphadiazine)FDA Link
5. Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
05/01/2019 - "HPM was mostly associated with patients with GPA with otitis media and/or mastoiditis having either type of ANCA serology. "
02/01/2014 - "Myeloperoxidase-ANCA-positive hypertrophic pachymeningitis was characterized by: (i) an elderly female predominance; (ii) 82% of patients diagnosed with granulomatosis with polyangiitis (previously known as Wegener's granulomatosis) according to Watts' algorithm; (iii) a high frequency of patients with lesions limited to the dura mater and upper airways, developing headaches, chronic sinusitis, otitis media or mastoiditis; (iv) a low frequency of patients with the 'classical or generalized form' of granulomatosis with polyangiitis involving the entire upper and lower airways and kidney, or progressing to generalized disease, in contrast to proteinase 3-ANCA-positive hypertrophic pachymeningitis; (v) less severe neurological damage according to the modified Rankin Scale and low disease activity according to the Birmingham Vasculitis Activity Score compared with proteinase 3-ANCA-positive hypertrophic pachymeningitis; (vi) increased levels of CXCL10, CXCL8 and interleukin 6 in cerebrospinal fluids, and increased numbers of T cells, neutrophils, eosinophils, plasma cells and monocytes/macrophages in autopsied or biopsied dura mater with pachymeningitis, suggesting TH1-predominant granulomatous lesions in hypertrophic pachymeningitis, as previously reported in pulmonary or renal lesions of granulomatosis with polyangiitis; and (vii) greater efficacy of combination therapy with prednisolone and cyclophosphamide compared with monotherapy with prednisolone. "
6. Prednisolone (Predate)FDA LinkGeneric
01/01/2019 - "These improvements were seen after prednisolone administration for mastoiditis and following prednisolone administration for kidney transplantation. "
02/01/2014 - "Myeloperoxidase-ANCA-positive hypertrophic pachymeningitis was characterized by: (i) an elderly female predominance; (ii) 82% of patients diagnosed with granulomatosis with polyangiitis (previously known as Wegener's granulomatosis) according to Watts' algorithm; (iii) a high frequency of patients with lesions limited to the dura mater and upper airways, developing headaches, chronic sinusitis, otitis media or mastoiditis; (iv) a low frequency of patients with the 'classical or generalized form' of granulomatosis with polyangiitis involving the entire upper and lower airways and kidney, or progressing to generalized disease, in contrast to proteinase 3-ANCA-positive hypertrophic pachymeningitis; (v) less severe neurological damage according to the modified Rankin Scale and low disease activity according to the Birmingham Vasculitis Activity Score compared with proteinase 3-ANCA-positive hypertrophic pachymeningitis; (vi) increased levels of CXCL10, CXCL8 and interleukin 6 in cerebrospinal fluids, and increased numbers of T cells, neutrophils, eosinophils, plasma cells and monocytes/macrophages in autopsied or biopsied dura mater with pachymeningitis, suggesting TH1-predominant granulomatous lesions in hypertrophic pachymeningitis, as previously reported in pulmonary or renal lesions of granulomatosis with polyangiitis; and (vii) greater efficacy of combination therapy with prednisolone and cyclophosphamide compared with monotherapy with prednisolone. "
7. Interleukin-6 (Interleukin 6)IBA
8. Peptide Hydrolases (Proteases)FDA Link
9. Peroxidase (Myeloperoxidase)IBA
10. Cyclophosphamide (Cytoxan)FDA LinkGeneric

Therapies and Procedures

1. Therapeutics
2. Mastoidectomy
3. Conservative Treatment
4. Curettage
5. Cochlear Implants (Cochlear Implant)