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Marfan Syndrome (Marfan's Syndrome)

An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE; AORTIC ANEURYSM; and AORTIC DISSECTION. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome (type 1) is associated with mutations in the gene encoding FIBRILLIN-1 (FBN1), a major element of extracellular microfibrils of connective tissue. Mutations in the gene encoding TYPE II TGF-BETA RECEPTOR (TGFBR2) are associated with Marfan syndrome type 2.
Also Known As:
Marfan's Syndrome; Marfans Syndrome; Marfan Syndrome, Type I; Marfan Like Connective Tissue Disorder; Marfan Syndrome Type 1; Marfan Syndrome Type 2; Marfan Syndrome, Type II
Networked: 1773 relevant articles (37 outcomes, 139 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Aortic Aneurysm (Aneurysm, Aortic)
2. Thoracic Aortic Aneurysm
3. Aortic Dissection
4. Ectopia Lentis
5. Aortic Root Aneurysm

Experts

1. Dietz, Harry C: 42 articles (01/2020 - 04/2002)
2. Ramirez, Francesco: 33 articles (02/2022 - 03/2003)
3. Boileau, Catherine: 26 articles (01/2021 - 04/2002)
4. Reinhardt, Dieter P: 24 articles (05/2022 - 12/2002)
5. Jondeau, Guillaume: 22 articles (10/2022 - 05/2002)
6. Mulder, Barbara J M: 19 articles (12/2021 - 07/2002)
7. De Backer, Julie: 17 articles (11/2021 - 08/2009)
8. Robinson, Peter N: 17 articles (12/2019 - 09/2002)
9. Groenink, Maarten: 16 articles (12/2021 - 07/2002)
10. Zwinderman, Aeilko H: 16 articles (12/2021 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Marfan Syndrome:
1. Losartan (Cozaar)FDA LinkGeneric
2. Angiotensin Receptor AntagonistsIBA
3. Fibrillin-1IBA
4. Atenolol (Tenormin)FDA LinkGeneric
5. Adrenergic Agents (Adrenergic Drugs)IBA
6. Capsules (Microcapsules)IBA
7. Transforming Growth Factors (Transforming Growth Factor)IBA
8. Transforming Growth Factor beta (TGF-beta)IBA
9. DNA (Deoxyribonucleic Acid)IBA
10. Angiotensin IIIBA

Therapies and Procedures

1. Therapeutics
2. Replantation
3. Intraocular Lenses (Intraocular Lens)
4. Lenses
5. Prostheses and Implants (Prosthesis)