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Marburg Virus Disease

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An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.

Also Known As:

Marburg Disease; Marburg Hemorrhagic Fever; Disease, Marburg; Fever, Marburg Hemorrhagic; Hemorrhagic Fever, Marburg

Networked: 17 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Virus Diseases: 1820
- RNA Virus Infections: 103
  - Viral Hemorrhagic Fevers: 57
    - Marburg Virus Disease: 17
  - Mononegavirales Infections: 1
    - Filoviridae Infections
      - Marburg Virus Disease: 17
Animal Diseases: 182
- Primate Diseases: 2
  - Monkey Diseases: 1
    - Marburg Virus Disease: 17

Related Diseases

1.	Infection
2.	Sepsis (Septicemia)
3.	Yellow Fever
4.	West Nile Fever
5.	Epidemic Louse-Borne Typhus (Typhus)

Experts

1.	Geisbert, Thomas W: 3 articles (10/2015 - 02/2007)
2.	Kemp, Alan: 2 articles (07/2009 - 08/2006)
3.	Nichol, Stuart T: 2 articles (07/2009 - 08/2006)
4.	Rollin, Pierre E: 2 articles (07/2009 - 08/2006)
5.	Swanepoel, Robert: 2 articles (07/2009 - 08/2006)
6.	Bausch, Daniel G: 2 articles (02/2007 - 08/2006)
7.	Ebihara, Hideki: 1 article (10/2015)
8.	Fenton, Karla A: 1 article (10/2015)
9.	Geisbert, Joan B: 1 article (10/2015)
10.	Mire, Chad E: 1 article (10/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Marburg Virus Disease:

1.	Viral RNAIBA 07/01/2010 - "The assay was further evaluated using viral RNA extracted from clinical specimens collected in the 2005 Marburg hemorrhagic fever outbreak in Angola and yielded positive results for samples containing MARV at greater than 10(4) 50% tissue culture infective doses/ml, exhibiting 78% (14 of 18 samples positive) consistency with the results of a reverse transcription-PCR assay carried out in the field laboratory. "
2.	InterferonsIBA 07/15/2013 - "Interferon-β therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever." 07/01/2001 - "The possibility of emergency prophylaxis of Marburg hemorrhagic fever with leukocytic and recombinant interferons was studied in experiments on Cercopithecus aethiops. " 07/01/2001 - "The use of interferon for emergency prophylaxis of marburg hemorrhagic fever in monkeys." 09/01/1996 - "[Experimental study of possible treatment of Marburg hemorrhagic fever with desferal, ribavirin, and homologous interferon]."
3.	Ribavirin (Virazole)FDA LinkGeneric 09/01/1996 - "[Experimental study of possible treatment of Marburg hemorrhagic fever with desferal, ribavirin, and homologous interferon]."
4.	Deferoxamine (Desferal)FDA LinkGeneric 09/01/1996 - "[Experimental study of possible treatment of Marburg hemorrhagic fever with desferal, ribavirin, and homologous interferon]."
5.	infliximab (Remicade)FDA Link 01/01/2004 - "[An experimental study of possibility of treatment of hemorrhagic fever Marburg by Remicade]." 01/01/2004 - "The effect of Remicade, administered according to different schemes, produced on the course of experimental Marburg hemorrhagic fever was studied. "
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/1998 - "The paper provides data on the effect of tumor necrosis factor (TNF) antiserum on the course of experimental Marburg hemorrhagic fever. " 01/01/1998 - "[Effects of tumor necrosis factor antiserum of the course of Marburg hemorrhagic fever]." 09/01/1996 - "It is suggested that tumor necrosis factor may contribute to development of Marburg hemorrhagic fever." 01/01/2004 - "Hence, it can be an evidence of a dual TNF-alpha role in the immunopathogenesis of Marburg hemorrhagic fever: on day 1 after infection the production of TNF-alpha is needed; whereas, if there is an overproduction of the cytokine, it is necessary to inhibit it. "
7.	VaccinesIBA 02/01/2007 - "Development of vaccines for Marburg hemorrhagic fever." 10/01/2015 - "Although both strains exhibit great similarity to pathogenic markers of human and nonhuman primate MARV infection, these data highlight several key differences in pathogenicity that may serve to guide the choice of strain and model used for development of vaccines or therapeutics for Marburg hemorrhagic fever."
8.	AntibodiesIBA 09/01/1999 - "Serum from a convalescent after Marburg disease and polyclonal antibodies from animals immunized with MBG recognized f35 and the MBG VP35. " 05/01/1997 - "The level of specific antibodies in the blood of Cercopithecus aethiops monkeys with experimental Marburg hemorrhagic fever appreciably affects the incidence of lethal outcomes in immunized animals infected with Marburg virus. " 05/01/1997 - "[Relationship between the level of specific antibodies with disease outcome in Cercopithecus aethiops monkeys in experimental Marburg disease]."
9.	CytokinesIBA 01/01/1998 - "It may be assumed that a course of death due to Marburg hemorrhagic fever in shocks brought about by inflammatory cytokines. "
10.	NucleoproteinsIBA 05/01/2005 - "In order to establish a diagnostic system for Marburg hemorrhagic fever by the detection of Marburg virus nucleoprotein, monoclonal antibodies to the recombinant nucleoprotein were produced. "

Therapies and Procedures

Therapeutics

07/01/2009 - "The lack of a mouse model has hampered an understanding of the pathogenesis and immunity of Marburg hemorrhagic fever (MHF), the disease caused by marburgvirus (MARV), and has created a bottleneck in the development of antiviral therapeutics. "
10/01/2015 - "Although both strains exhibit great similarity to pathogenic markers of human and nonhuman primate MARV infection, these data highlight several key differences in pathogenicity that may serve to guide the choice of strain and model used for development of vaccines or therapeutics for Marburg hemorrhagic fever."