Mansonelliasis

Infection with nematodes of the genus MANSONELLA. Symptoms include pruritus, headache, and articular swelling.

Also Known As:

Acanthocheilonema perstans Infection; Dipetalonema perstans Infection; Mansonella perstans Infections; Mansonellosis; Acanthocheilonema perstans Infections; Dipetalonema perstans Infections; Infection, Acanthocheilonema perstans; Infection, Dipetalonema perstans; Infection, Mansonella perstans; Infections, Acanthocheilonema perstans; Infections, Dipetalonema perstans; Infections, Mansonella perstans; Mansonella perstans Infection; Mansonelliases; Mansonelloses; perstans Infection, Acanthocheilonema; perstans Infection, Dipetalonema; perstans Infection, Mansonella; perstans Infections, Acanthocheilonema; perstans Infections, Dipetalonema; perstans Infections, Mansonella

Networked: 35 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Parasitic Diseases: 4870
  - Helminthiasis: 527
    - Nematode Infections: 949
      - Secernentea Infections
        Spirurida Infections: 3
        Filariasis: 1098
        Mansonelliasis: 35

Related Diseases

1.	Onchocerciasis
2.	Body Weight (Weight, Body)
3.	Infections
4.	Loiasis
5.	Filarial Elephantiasis (Lymphatic Filariasis)

Experts

1.	Nutman, Thomas B: 3 articles (10/2009 - 01/2003)
2.	Hoerauf, Achim: 2 articles (01/2019 - 01/2016)
3.	Layland, Laura E: 2 articles (01/2019 - 01/2016)
4.	Ritter, Manuel: 2 articles (01/2019 - 01/2016)
5.	Fontes, Gilberto: 2 articles (03/2018 - 06/2014)
6.	Medeiros, Jansen Fernandes: 2 articles (03/2018 - 06/2014)
7.	Coulibaly, Siaka Y: 2 articles (10/2009 - 07/2009)
8.	Coulibaly, Yaya I: 2 articles (10/2009 - 07/2009)
9.	Diallo, Abdallah A: 2 articles (10/2009 - 07/2009)
10.	Doumbia, Salif S: 2 articles (10/2009 - 07/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mansonelliasis:

1.	Ivermectin (Mectizan)FDA Link 01/01/2016 - "MDA with ivermectin induced significant reduction in the endemicity of mansonellosis in the decidious equatorial rainforest. " 12/01/2003 - "Impact of long-term ivermectin (Mectizan) on Wuchereria bancrofti and Mansonella perstans infections in Burkina Faso: strategic and policy implications." 12/01/1999 - "Ivermectin treatment of mansonellosis in Trinidad." 09/01/1998 - "Single dose of ivermectin to control mansonellosis in Trinidad: a four-years follow-up study." 12/01/1996 - "Ivermectin treatment of mansonellosis in Blanchisseuse, Trinidad, West Indies."
2.	Doxycycline (Periostat)FDA LinkGeneric 01/01/2019 - "The Efficacy of Doxycycline Treatment on Mansonella perstans Infection: An Open-Label, Randomized Trial in Ghana." 10/08/2009 - "A randomized trial of doxycycline for Mansonella perstans infection." 01/01/2023 - "Doxycycline is used for treatment of Mansonella perstans infection. " 01/21/2010 - "Doxycycline for Mansonella perstans infection."
3.	Albendazole (Albenza)FDA Link 12/01/2016 - "While most cases are asymptomatic, mansonelliasis can be associated with angioedema, arthralgia, swellings, pain in the scrotum or in serous cavities such as the pleura, the peritoneum, the pericardium, etc. Mansonelliasis can be really hard to treat, but it has been shown that an intensive treatment using albendazole can clear the parasite. " 03/01/2009 - "A randomised, double-blind field trial of ivermectin alone and in combination with albendazole for the treatment of Mansonella perstans infections in Uganda." 03/01/2009 - "The effect of a single dose of ivermectin alone (150-200microg/kg body weight) or in combination with albendazole (total of 400mg) in Mansonella perstans infection was assessed in a randomised, double-blind field trial in two endemic communities in Mukono and Luwero districts of Uganda. " 06/01/2021 - "Albendazole is also used for treatment of filarial infections (lymphatic filariasis, onchocerciasis, loiasis, mansonellosis, and dirofilariasis) alone or in combination with other drugs, such as ivermectin or diethylcarbamazine. "
4.	Anti-Bacterial Agents (Antibiotics)IBA 05/08/2023 - "The new genomes provide a valuable resource for further studies on symbiosis, evolution, and the discovery of new antibiotics to treat mansonellosis." 11/15/2014 - "Before generalizing the use of antibiotics for mansonellosis, further clarification of the obligatory nature of the endosymbiosis in this nematode is needed. " 08/01/2003 - "The absence of Wolbachia in both filarial species therefore discourages the use of antibiotics as an adjunct or alternative approach to current treatment concepts for both loiasis and mansonelliasis perstans."
5.	Mebendazole (Anti-Worm)FDA Link 06/01/1987 - "Patients harbouring Loa loa and/or Mansonella perstans infections, or presenting typical filarial symptomatology, were treated with mebendazole, a drug shown to be efficient in other parasitoses. " 01/01/1983 - "Treatment of Dipetalonema perstans infections with mebendazole." 10/01/2022 - "However, 30% of patients with loiasis and mansonellosis experienced treatment failure (with diethylcarbamazine and levamisole-mebendazole, respectively). " 01/01/2021 - "The ivermectin and mebendazole-based mass drug administration (iMDA and mMDA) treatment regimens deployed by the WHO´s Elimination of Neglected Tropical Diseases (ESPEN) programme and its forerunners have, however, likely impacted significantly on the mansonellosis disease burden, principally by reducing the transmission of M. "
6.	Proteins (Proteins, Gene)FDA Link 12/01/2000 - "Use of the recombinant Onchocerca volvulus protein Ov20/OvS1 for the immunodiagnostic differentiation between onchocerciasis and mansonelliasis and for the characterization of hyperreactive onchocerciasis (sowda)." 12/01/2000 - "The protein Ov20/OvS1 was used as antigen in ELISA and Western blot in order to differentiate onchocerciasis from African mansonelliasis and to characterize the hyperreactive form of Onchocerca volvulus infection (sowda). " 01/01/2019 - "We studied the spontaneous and inducible cellular production of chemokines (C-X-C motif) ligand 9 (CXCL9) [monokine induced by interferon (IFN)-γ (MIG)], CXCL-10 [inducible protein (IP)-10], chemokine (C-C motif) ligand 24 (CCL24) (eotaxin-2), CCL22 [macrophage-derived chemokine (MDC)], CCL13 [monocyte chemotactic protein-4 (MCP-4)], CCL18 [pulmonary and activation-regulated chemokine (PARC)], CCL17 [thymus- and activation-regulated chemokine (TARC)] and interleukin (IL)-27 in mansonelliasis patients (Mp-PAT) and mansonelliasis-free controls (CTRL). "
7.	InterleukinsIBA 12/16/2010 - "Maternal Mansonella perstans infection was associated with higher interleukin (IL)-10 responses to both immunogens but no reduction in gamma interferon (IFN-γ), IL-5 and IL-13 responses; other maternal helminth infections showed little effect. " 01/01/2019 - "We studied the spontaneous and inducible cellular production of chemokines (C-X-C motif) ligand 9 (CXCL9) [monokine induced by interferon (IFN)-γ (MIG)], CXCL-10 [inducible protein (IP)-10], chemokine (C-C motif) ligand 24 (CCL24) (eotaxin-2), CCL22 [macrophage-derived chemokine (MDC)], CCL13 [monocyte chemotactic protein-4 (MCP-4)], CCL18 [pulmonary and activation-regulated chemokine (PARC)], CCL17 [thymus- and activation-regulated chemokine (TARC)] and interleukin (IL)-27 in mansonelliasis patients (Mp-PAT) and mansonelliasis-free controls (CTRL). "
8.	Diethylcarbamazine (Hetrazan)FDA Link 10/01/2022 - "However, 30% of patients with loiasis and mansonellosis experienced treatment failure (with diethylcarbamazine and levamisole-mebendazole, respectively). " 06/01/2021 - "Albendazole is also used for treatment of filarial infections (lymphatic filariasis, onchocerciasis, loiasis, mansonellosis, and dirofilariasis) alone or in combination with other drugs, such as ivermectin or diethylcarbamazine. "
9.	Chemokine CCL22IBA 01/01/2019 - "We studied the spontaneous and inducible cellular production of chemokines (C-X-C motif) ligand 9 (CXCL9) [monokine induced by interferon (IFN)-γ (MIG)], CXCL-10 [inducible protein (IP)-10], chemokine (C-C motif) ligand 24 (CCL24) (eotaxin-2), CCL22 [macrophage-derived chemokine (MDC)], CCL13 [monocyte chemotactic protein-4 (MCP-4)], CCL18 [pulmonary and activation-regulated chemokine (PARC)], CCL17 [thymus- and activation-regulated chemokine (TARC)] and interleukin (IL)-27 in mansonelliasis patients (Mp-PAT) and mansonelliasis-free controls (CTRL). "
10.	Chemokine CCL17IBA 01/01/2019 - "We studied the spontaneous and inducible cellular production of chemokines (C-X-C motif) ligand 9 (CXCL9) [monokine induced by interferon (IFN)-γ (MIG)], CXCL-10 [inducible protein (IP)-10], chemokine (C-C motif) ligand 24 (CCL24) (eotaxin-2), CCL22 [macrophage-derived chemokine (MDC)], CCL13 [monocyte chemotactic protein-4 (MCP-4)], CCL18 [pulmonary and activation-regulated chemokine (PARC)], CCL17 [thymus- and activation-regulated chemokine (TARC)] and interleukin (IL)-27 in mansonelliasis patients (Mp-PAT) and mansonelliasis-free controls (CTRL). "

Therapies and Procedures

1.	Therapeutics 06/01/2014 - "Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment. " 10/01/2022 - "Case management would benefit from more effective therapies for loiasis and mansonellosis." 01/01/2021 - "However, a potentially far greater mansonellosis disease burden impact is likely to come from short-course curative anti-Wolbachia therapeutics, which are presently being developed for onchocerciasis and lymphatic filariasis treatment. "
2.	Mass Drug Administration 01/01/2021 - "The ivermectin and mebendazole-based mass drug administration (iMDA and mMDA) treatment regimens deployed by the WHO´s Elimination of Neglected Tropical Diseases (ESPEN) programme and its forerunners have, however, likely impacted significantly on the mansonellosis disease burden, principally by reducing the transmission of M. "