Mannich Bases

Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as the equivalent of an alpha,beta unsaturated ketone in synthesis or can be reduced to form physiologically active amino alcohols.

Also Known As:

Networked: 78 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Deng, Yong: 8 articles (01/2022 - 01/2017)
2.	Cao, Zhongcheng: 5 articles (01/2021 - 01/2017)
3.	Qiang, Xiaoming: 5 articles (01/2020 - 01/2017)
4.	Song, Qing: 4 articles (01/2021 - 01/2019)
5.	Tan, Zhenghuai: 4 articles (01/2021 - 01/2017)
6.	Li, Yan: 4 articles (01/2019 - 01/2017)
7.	Luo, Li: 3 articles (01/2017 - 01/2017)
8.	Yang, Xia: 3 articles (01/2017 - 01/2017)
9.	Enyedy, Éva A: 2 articles (01/2022 - 01/2021)
10.	Liu, Zhuoling: 2 articles (01/2022 - 01/2021)

Related Diseases

1.	Malaria 01/01/2005 - "Other potential malaria chemoprophylactic drugs such as third-generation antifol compounds and Mannich bases have reached advanced preclinical testing. " 04/23/2009 - "Pyronaridine, a Mannich base anti-malarial with high efficacy against drug resistant Plasmodium falciparum, is currently evaluated as a fixed dose combination with artesunate for the treatment of uncomplicated malaria. " 10/01/1992 - "The activities of Mannich base antimalarials, including pyronaridine, have been explored against drug-sensitive (Plasmodium berghei N) and chloroquine-resistant (Plasmodium yoelii NS) rodent malaria parasites in vivo. " 12/01/1984 - "The chemotherapy of rodent malaria, XXXVII. The in vivo action of two Mannich bases, WR 194,965 and WR 228,258 and an 8-aminoquinoline WR 225,448."
2.	Seizures (Absence Seizure) 10/01/2016 - "The new N-Mannich bases were effective in maximal electroshock or pentylenetetrazole seizures screens; and the most interesting compound 4 (1-{[4-(1-phenyethyl)-piperazin-1-yl]methyl}-3',4'-dihydro-1'H,2H,5H-spiro[imidazolidine-4,2'-naphthalene]-2,5-dione) displayed anticonvulsant activity in both the aforementioned tests. "
3.	Neoplasms (Cancer) 11/15/2015 - "Synthesis, biological evaluation and structure-activity relationship studies of isoflavene based Mannich bases with potent anti-cancer activity." 07/01/2017 - "In particular, thioxoflavone 4 and the thioxoflavone Mannich base derivatives 5a and 5d showed the best antiproliferative activity on all three human cancer cell lines; they are promising candidates worthy of further development. " 07/01/2017 - "The results showed that most of the thioxoflavones and their Mannich base derivatives exhibited potential antiproliferative activities on the tested cancer cell lines, with IC50 values ranging from 9.16 to 55.50 μM. " 07/15/2015 - "The synthesized Mannich bases were screened for in vitro growth inhibition against a panel of 3 different human cancer cell lines. " 09/15/2013 - "The nature of Mannich base substituent on C-2 atom at the aromatic ring may be critical in the search for selectivity towards a particular cancer cell."
4.	Neuroblastoma 08/01/2020 - "In this study, we have targeted the P53 pathway by novel Mannich base (3FB3FA8H) which can be a future prospect to cure neuroblastoma. " 08/01/2020 - "Novel Mannich base 3FB3FA8H induces apoptosis by upregulating P53 pathway in neuroblastoma cells." 11/15/2015 - "The resulting Mannich bases exhibited prominent anti-proliferative effects against SHEP neuroblastoma and MDA-MB-231 breast adenocarcinoma cell lines. "
5.	Hepatocellular Carcinoma (Hepatoma) 05/14/2016 - "The present study was designed to evaluate the antitumor effects of the synthetic Mannich base 1,3-bis-((3-hydroxynaphthalen-2-yl)phenylmethyl)urea (1,3-BPMU) against HEP-G2 hepatoma cells and diethylnitrosamine (DEN)-induced hepatocarcinoma (HCC) in albino rats. " 06/01/2020 - "Novel Mannich base derivatives of glabridin were synthesized and their antiproliferative activity were performed along with our previously reported glabridin-chalcone hybrids molecules (GCHMs) against various human cell lines MDA-MB-231 (breast adenocarcinoma), HEK-293 (embryonic kidney cell line), K562 (leukemia), MCF-7 (breast adenocarcinoma), HeLa (cervix adenocarcinoma), HepG2 (hepatocellular carcinoma) and WRL-68 (hepatic carcinoma). "

Related Drugs and Biologics

1.	Antimalarials (Antimalarial Agents)
2.	Anticonvulsants (Antiepileptic Drugs)
3.	pyronaridine
4.	Imidazolidines
5.	Pentylenetetrazole (Metrazol)
6.	Artesunate
7.	naphthalene
8.	Antioxidants
9.	Acids
10.	Thymol

Related Therapies and Procedures

1.	Transplantation
2.	Drug Therapy (Chemotherapy)