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Mallory-Weiss Syndrome

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A condition characterized by mucosal tears at the ESOPHAGOGASTRIC JUNCTION, sometimes with HEMATEMESIS. Typically it is caused by forceful bouts of retching or VOMITING.

Also Known As:

Gastroesophageal Laceration-Hemorrhage; Mallory-Weiss Laceration; Mallory-Weiss Tear; Mucosal Lacerations-Gastroesophageal Junction; Gastroesophageal Laceration Hemorrhage; Gastroesophageal Laceration-Hemorrhages; Junction, Mucosal Lacerations-Gastroesophageal; Junctions, Mucosal Lacerations-Gastroesophageal; Laceration, Mallory-Weiss; Laceration-Hemorrhage, Gastroesophageal; Laceration-Hemorrhages, Gastroesophageal; Lacerations-Gastroesophageal Junction, Mucosal; Lacerations-Gastroesophageal Junctions, Mucosal; Mallory Weiss Laceration; Mallory Weiss Syndrome; Mallory Weiss Tear; Mucosal Lacerations Gastroesophageal Junction; Mucosal Lacerations-Gastroesophageal Junctions; Syndrome, Mallory-Weiss

Networked: 80 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 46
- Gastrointestinal Diseases: 1735
  - Esophageal Diseases: 177
    - Esophageal Perforation: 448
      - Mallory-Weiss Syndrome: 80

Related Diseases

1.	Hemorrhage
2.	Shock
3.	Stomach Ulcer (Gastric Ulcer)
4.	Duodenal Ulcer (Curling's Ulcer)
5.	Confusion (Bewilderment)

Experts

1.	Kudo, Taiki: 1 article (05/2014)
2.	Sakamoto, Naoya: 1 article (05/2014)
3.	Haba, Shin: 1 article (05/2014)
4.	Onodera, Manabu: 1 article (05/2014)
5.	Kawakubo, Kazumichi: 1 article (05/2014)
6.	Kuwatani, Masaki: 1 article (05/2014)
7.	Kawahata, Shuhei: 1 article (05/2014)
8.	Kawakami, Hiroshi: 1 article (05/2014)
9.	Abe, Yoko: 1 article (05/2014)
10.	Eto, Kazunori: 1 article (05/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mallory-Weiss Syndrome:

1.	Epinephrine (Adrenaline)FDA LinkGeneric 06/01/2002 - "Thirty-five patients with Mallory-Weiss syndrome with spurting vessels or oozing in a university hospital were enrolled prospectively and randomly assigned to endoscopic hemoclip placement (18 patients) or endoscopic epinephrine injection (17 patients) performed by 4 endoscopists with similar clinical experiences. " 06/01/2002 - "This is an investigation of the respective efficacy and safety of endoscopic hemoclip placement and endoscopic epinephrine injection in Mallory-Weiss syndrome. " 07/01/2004 - "This study evaluated the respective efficacy and the safety of endoscopic band ligation and endoscopic epinephrine injection in Mallory-Weiss syndrome. " 06/01/2002 - "Endoscopic hemoclip placement and epinephrine injection for Mallory-Weiss syndrome with active bleeding." 01/01/1994 - "Hypertensive emergency and ventricular tachycardia after endoscopic epinephrine injection of a Mallory-Weiss tear."
2.	Boerhaave syndromeIBA 09/01/2009 - "Esophageal IMH may represent an intermediate stage between Mallory-Weiss tear (mucosal) and Boerhaave's syndrome (transmural). " 12/01/1992 - "The Mallory-Weiss syndrome and Boerhaave syndrome are distinct entities with some clinical similarities." 01/24/1981 - "[Mallory-Weiss syndrome, Boerhaave syndrome. " 10/01/1963 - "MALLORY-WEISS SYNDROME, BOERHAAVE SYNDROME, AND THEIR VARIANTS." 01/01/1982 - "The results of this study clarify the persistent confusion between the Mallory-Weiss syndrome and the Boerhaave's syndrome. "
3.	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 11/01/1995 - "Polyethylene glycol electrolyte lavage solution-induced Mallory-Weiss tear." 03/01/1992 - "I have reported two cases of Mallory-Weiss tear occurring after the patients drank an oral electrolyte/polyethylene glycol preparation before colonoscopy. " 05/01/1991 - "Mallory-Weiss tear associated with polyethylene glycol electrolyte lavage solution."
4.	Ipecac (Syrup of Ipecac)IBA 06/01/1984 - "Ipecac as a cause of the Mallory-Weiss syndrome." 10/01/1981 - "Mallory-Weiss syndrome: an unusual complication of ipecac-induced emesis."
5.	tebufenozide (Mimic)IBA 06/01/1993 - "The clinical presentation of mechanical gastritis and the Mallory-Weiss syndrome may mimic each other. " 05/01/1979 - "Historically, this condition may mimic the "Mallory-Weiss syndrome" and endoscopically, this lesion may be mistaken for "gastritis". "
6.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 09/01/2001 - "In our series, the patients with Mallory-Weiss syndrome with active bleeding or visible vessel presented a haemorrhage with a greater clinical and analytical repercussion. " 01/01/2012 - "On the day of the ESD, hematemesis was observed because of a Mallory-Weiss tear, and a visible vessel in the post-ESD ulcer was additionally treated endoscopically by coagulation. "
7.	Factor VIIa (Activated Factor VII)IBA 07/01/2008 - "Successful management of Mallory-Weiss syndrome in a haemophilia A patient with inhibitor by recombinant activated factor VII."
8.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 06/01/1989 - "The Authors report a case of Mallory-Weiss syndrome satisfactorily treated with Tissucol by endoscopy. " 06/01/1989 - "[Use of fibrin tissue adhesive (Tissucol) in Mallory-Weiss syndrome]."
9.	Vasopressins (Vasopressin)IBA 04/15/1971 - "Use of vasopressin in the Mallory-Weiss syndrome."
10.	Reserpine (Serpasil)FDA Link 10/01/1984 - "[A case of Mallory-Weiss syndrome as a complication of treatment with raupasil]."

Therapies and Procedures

1.	Endoscopic Hemostasis 10/01/1997 - "Endoscopic hemostasis may be effective in many of the conditions, but only Mallory-Weiss tear and Dieulafoy's lesion are encountered frequently enough to be clinically significant." 05/01/2014 - "One patient developed Mallory-Weiss syndrome, which required endoscopic hemostasis. " 01/01/2009 - "Endoscopic hemostasis with metallic hemoclips for iatrogenic Mallory-Weiss tear caused by endoscopic examination." 06/01/2002 - "Evaluation of endoscopic hemostasis in upper gastrointestinal bleeding related to Mallory-Weiss syndrome."
2.	Ligation 09/01/2006 - "This prospective study evaluated the efficacy and safety of endoscopic band ligation therapy for Mallory-Weiss syndrome. " 07/01/2000 - "Severe Mallory-Weiss tear after endoscopy treated by endoscopic band ligation." 09/01/2006 - "The study results suggest that endoscopic band ligation is an effective, safe, and easily learned procedure for treating upper gastrointestinal bleeding related to Mallory-Weiss syndrome." 04/07/2008 - "To compare the hemostatic efficacy and safety of two mechanical endoscopic methods: endoscopic band ligation (EBL) and endoscopic hemoclip placement (EHP) in patients with actively bleeding Mallory-Weiss syndrome (MWS). " 04/07/2008 - "Endoscopic band ligation and endoscopic hemoclip placement for patients with Mallory-Weiss syndrome and active bleeding."
3.	Sclerotherapy 01/01/2009 - "Applied endoscopic techniques including mucosal resection, sclerotherapy and endoscopic retrograde cholangiopancreatography (ERCP) have been advanced and iatrogenic complications including Mallory-Weiss tear (MWT) occasionally occur in daily endoscopic procedures. " 05/01/1990 - "Mallory-Weiss syndrome can also be observed as a cause of rebleeding in patients treated with chronic sclerotherapy. " 12/01/1994 - "The aim of this clinical study was to assess the usefulness of early endoscopic examination and sclerotherapy for severe or recurrent bleeding due to the Mallory-Weiss syndrome. " 08/01/1995 - "Endoscopic sclerotherapy for upper gastrointestinal bleeding due to Mallory-Weiss syndrome." 12/01/1994 - "Severe bleeding due to Mallory-Weiss syndrome can be successfully treated by sclerotherapy. "
4.	Surgical Instruments (Clip) 04/01/2010 - "The study involved 39 cases where hemostasis was attempted with bipolar forceps to deal with non-variceal upper gastrointestinal bleeding, including 28 cases of gastric ulcer, six cases of duodenal ulcer, three cases of bleeding after endoscopic submucosal dissection (ESD), one case of Mallory-Weiss syndrome and one case of postoperative bleeding from the anastomosed area. "
5.	Electrocoagulation (Electrocautery) 01/01/1983 - "Since Mallory-Weiss syndrome is a self-limiting disease in more than 90 percent of patients, conservative treatment, including multiple transfusion, electrocoagulation, and compression by a Sengstaken-Blakemore tube in descending order of use, is the treatment of choice, especially in the medically debilitated patient. " 09/01/1982 - "[Electrocoagulation for Mallory-Weiss syndrome]." 01/01/1993 - "Electrocoagulation was considered a success in patients with acute ulcers and cardiovascular disease, in cases of large erosive units of drug origin, in posteriorly located gastric ulcers, in Mallory-Weiss syndrome and in gastric cancer." 06/25/1987 - "Forty-four patients were randomly assigned to receive multipolar electrocoagulation or sham multipolar electrocoagulation if endoscopy revealed active bleeding from an ulcer (24 patients), a Mallory-Weiss tear (17), or a vascular malformation (3). "