Magnesium Sulfate (Sulfate, Magnesium)

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)

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Networked: 1437 relevant articles (155 outcomes, 280 trials/studies)

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Drug Context: Research Results

Experts

1.	Rouse, Dwight J: 15 articles (11/2015 - 01/2003)
2.	Sibai, Baha M: 12 articles (08/2014 - 06/2002)
3.	Mercer, Brian M: 9 articles (10/2015 - 10/2006)
4.	Mori, Kentaro: 8 articles (01/2014 - 04/2008)
5.	Mittendorf, Robert: 8 articles (07/2011 - 05/2002)
6.	Pryde, Peter G: 8 articles (07/2011 - 05/2002)
7.	Varner, Michael W: 7 articles (10/2015 - 08/2008)
8.	O'Sullivan, Mary J: 7 articles (10/2015 - 08/2008)
9.	Malone, Fergal D: 7 articles (10/2015 - 08/2008)
10.	Thorp, John M: 7 articles (10/2015 - 08/2008)

Related Diseases

1.	Eclampsia 07/01/2010 - "Despite the presence of high-quality evidence that magnesium sulfate is safe and effective at preventing and treating eclampsia, its use is extremely limited in many low-income countries. " 12/01/2001 - "Magnesium sulfate (MgSO4) is widely used for the treatment of eclampsia. " 02/01/1999 - "The data show that it is as effective as magnesium sulfate in preventing eclampsia, with less maternal and fetal side effects. " 03/01/2002 - "Magnesium sulfate therapy has been demonstrated to be both safe and effective in preventing neurological complications in obstetrical patients with eclampsia. " 04/01/1997 - "The results of this study are in support of a recent randomized trial on the efficacy of magnesium sulfate as a prophylactic agent against eclampsia. "
2.	Premature Obstetric Labor (Premature Labor) 06/01/2009 - "Magnesium sulfate is effective in delaying delivery for at least 48 hours in patients with preterm labor when used in higher dosages. " 02/01/1984 - "Magnesium sulfate has been recommended as a safe and effective agent for inhibiting preterm labor. " 01/01/1995 - "In conclusion, guidelines for prescribing intravenous magnesium sulfate to inhibit premature labor in singletons are equally safe and effective for twin gestations." 03/01/2000 - "This study was conducted to observe the relationship between the alteration of 6-keto-PGF 1 alpha and TXB2 in cervical mucus of patients with threatened preterm labor and the efficacy of magnesium sulfate treatment, and to examine whether they could act as markers of efficacy and prognosis in treatment of preterm labor. " 03/01/1992 - "To observe the efficacy of magnesium sulfate in the treatment of preterm labor, 65 uncomplicated cases of preterm labor between 28 and 36 weeks of gestation were studied prospectively during Sep. "
3.	Seizures (Seizure) 03/01/2012 - "Magnesium sulfate was effective in controlling convulsions in 98.1% of women. " 02/01/2009 - "Low dose i.v. magnesium sulfate regimen is equally effective in prevention of convulsion recurrence and maternal deaths in eclamptic women when compared with an i.m. " 01/01/1997 - "In addition, the efficacy of magnesium sulfate in the prevention and control of eclamptic convulsion has been validated in randomized controlled trials performed worldwide. " 10/01/2012 - "Magnesium sulfate is the first-line treatment for the prevention of primary and recurrent eclamptic seizures. " 06/01/2002 - "Data were collected regarding the relationship of the patient's first seizure to delivery, prodromal symptoms, neuroimaging studies, use of magnesium sulfate, antihypertensive therapy, and follow-up medical care. "
4.	Asthma (Bronchial Asthma) 10/01/2000 - "Children treated with 40 mg/kg of intravenous magnesium sulfate for moderate to severe asthma showed remarkable improvement in short-term pulmonary function." 09/01/2000 - "However, magnesium sulfate appears to be safe and beneficial for patients who present with severe acute asthma. " 01/01/2000 - "Magnesium sulfate appears to be safe and beneficial in patients who present with severe acute asthma." 09/01/1989 - "Intravenous magnesium sulfate may represent a beneficial adjunct therapy in patients with moderate to severe asthma who show little improvement with beta-agonists." 02/01/2000 - "Magnesium sulfate is effective for severe acute asthma treated in the emergency department."
5.	Pre-Eclampsia (Preeclampsia) 02/01/2015 - "Magnesium sulfate affords protection against oxidative damage during severe preeclampsia." 11/01/2014 - "Cerebral oximetry assessed by near-infrared spectrometry during preeclampsia: an observational study: impact of magnesium sulfate administration." 05/01/2014 - "The aim of this study was to determine the amount of magnesium sulfate involved when we diagnose a severe preeclampsia in pregnant women. " 05/01/2012 - "Randomized controlled study comparing effect of magnesium sulfate with placebo on fetal umbilical artery and middle cerebral artery blood flow in mild preeclampsia at ≥ 34 weeks gestational age." 01/01/2012 - "Treatment approaches for preeclampsia in low-resource settings: A randomized trial of the Springfusor pump for delivery of magnesium sulfate."

Related Drugs and Biologics

1.	Magnesium
2.	Terbutaline (Brethaire)
3.	Phenytoin (Dilantin)
4.	Ritodrine (Yutopar)
5.	Nifedipine (Adalat)
6.	Calcium Gluconate (CBG)
7.	Calcium
8.	N-Methylaspartate (NMDA)
9.	Amiodarone (Amiodarona)
10.	Diazepam (Valium)

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1.	Tocolysis
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3.	General Anesthesia
4.	Ligation
5.	Hysterectomy