Lysophospholipase (Phospholipase B)

An enzyme that catalyzes the hydrolysis of a single fatty acid ester bond in lysoglycerophosphatidates with the formation of glyceryl phosphatidates and a fatty acid. EC 3.1.1.5.

Also Known As:

Phospholipase B; Lysolecithin-Lysolecithin Acyltransferase; Lysophospholipase A; Lysophospholipase A1; Lysophospholipase C; Lysophospholipase L2; Acyltransferase, Lysolecithin-Lysolecithin; L2, Lysophospholipase; Lysolecithin Lysolecithin Acyltransferase; Lecithinase B; Lysolecithinase; 2-Lysophosphatidylcholine acylhydrolase

Networked: 88 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Xu, Jin: 3 articles (06/2017 - 07/2007)
2.	Yu, Xinbing: 3 articles (06/2017 - 07/2007)
3.	Hashimura, Satoru: 2 articles (09/2020 - 01/2020)
4.	Hidaka, Mayumi: 2 articles (09/2020 - 01/2020)
5.	Inagaki, Yuji: 2 articles (09/2020 - 01/2020)
6.	Inoue-Fujiwara, Manami: 2 articles (09/2020 - 01/2020)
7.	Kido, Junichi: 2 articles (09/2020 - 01/2020)
8.	Matsuda, Risa: 2 articles (09/2020 - 01/2020)
9.	Matsui, Hirokazu: 2 articles (09/2020 - 01/2020)
10.	Nagata, Toshihiko: 2 articles (09/2020 - 01/2020)

Related Diseases

1.	Infections 05/01/1980 - "Determination of fecal phospholipase B activity constitutes a relatively simple, quantitative, and blood-free method of following the course of infection and its response to treatment, which might be of particular advantage in long term studies and preliminary therapeutic screening." 04/01/1994 - "The activity of lysophospholipase of human erythrocytes increased by about 3 orders of magnitude upon infection with Plasmodium falciparum. " 10/01/1982 - "Marked increases in phospholipase B activity were measured in spleen homogenates and sera of CD-1 mice given a primary infection of Plasmodium yoelii. " 03/01/1981 - "Rats given one infection showed a pronounced elevation of phospholipase B in the proximal half of the small intestine by the end of the 1st week, with a gradual decline to values within the range for uninfected controls by the 4th week. " 08/01/1980 - "Although the peak levels of lysophospholipase in the intestinal tissues occurred in both nulliparous and lactating mice by days 9 and 14 after infection with N. "
2.	Schistosomiasis haematobia (Schistosomiasis haematobium) 03/01/2008 - "Schistosome lysophospholipase may represent a new target for anti-schistosomal chemotherapy given that metrifonate, which targets the related enzyme acetylcholinesterase, is an effective and safe medicine for treatment of urinary schistosomiasis."
3.	Inflammation (Inflammations) 01/01/1977 - "The results, which support our hypothesis that inflammation, elevated phospholipase B activity, and reduction in worm burden are causally related, are discussed in light of similar findings reported earlier from our studies with Trichinella spiralis and Nippostrongylus brasiliensis." 01/01/1975 - "The association in mice of intestinal inflammation, elevated levels of phospholipase B, and expulsion of Trichinella spiralis." 01/01/1972 - "The action of purified phospholipase B in inflammation and immunity." 12/01/1992 - "Expression of the CLC gene confirms the authenticity of the CLC cDNA, the expression of lysophospholipase activity by this unique eosinophil and basophil constituent, and will facilitate the routine purification of the active enzyme for in vitro and animal model studies of its role (or roles) in eosinophil and basophil associated allergic inflammation and eosinophil-parasite interactions."
4.	Parasitic Diseases (Parasitic Disease) 01/01/1987 - "The results support a role for cell cooperation in the eosinophils production of lysophospholipase during a parasitic infection. " 10/15/2002 - "Previous studies have shown the high lysophospholipase activity of rat eosinophilic leukocytes and used this enzyme to measure the rise in eosinophilic population of peripheral tissues caused by parasitic infections. " 10/01/1979 - "The response was similar to that found in rodents infected with helminth parasites, thus demonstrating that phospholipase B is not unique to rodent models and is probably part of the complex immune response of the host in defense against parasitic infections."
5.	Pruritus (Itching) 04/01/2016 - "The present study aimed at evaluating autotaxin (ATX), a lysophospholipase recently identified as potential cause for cholestatic pruritus, in pediatric cholestatic diseases presenting with or without itching. " 10/01/2012 - "Recent experimental evidence implicated the lysophospholipase, autotaxin (ATX), and its product, lysophosphatidic acid (LPA), as potential mediators of cholestatic pruritus. "

Related Drugs and Biologics

1.	Enzymes
2.	Trichlorfon (Metrifonate)
3.	Thiabendazole (Mintezol)
4.	Niridazole
5.	Niclosamide
6.	Acetylcholinesterase
7.	Proteins (Proteins, Gene)
8.	Galectin 1 (LGALS1)
9.	Complementary DNA (cDNA)
10.	Annexin A1

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)