Lynestrenol

08/01/1987 - "Fifty patients with moderate or severe endometriosis received 5 mg/day lynestrenol for 6 months prior to microsurgery. "
01/01/1985 - "Before pregnancy an extensive process of nodular endometriosis of internal genital organs was diagnosed and treated with lynestrenol three times during the periods of several months."
06/01/1973 - "Marked transformation and involution phenomena were observed in relation to lynestrenol-induced pseudogravidal changes of mucus membrane in a small (nut-size) retrocervical endometriosis. "
02/01/1970 - "[Surgical treatment of endometriosis and long-term therapy with lynestrenol]."
01/01/1969 - "[Surgical and long-term lynestrenol treatment of endometriosis]."

01/01/2013 - "The reduction in uterine fibroid size was significantly greater in the leuprorelin group at 16 weeks compared to the progestogen lynestrenol group (MD -15.93 mm, 95% CI -18.02 to -13.84 mm, 46 women). "
06/01/2001 - "An unblinded trial versus lynestrenol in non anaemic women showed a superior effect of leuprorelin on the size of the leiomyoma, but again there were no data on a possible effect on the choice of surgical technique. "
07/01/2013 - "Progestin, such as lynestrenol induces small reduction in leiomyoma volume and moderate increase in hemoglobin level before surgery. "
12/01/2011 - "Progestin, such as lynestrenol induces small reduction in leiomyoma volume and moderate increase in hemoglobin level before surgery. "
01/01/2001 - "Lynestrenol did not offer any advantage over GnRH analogue therapy before fibroid surgery. "

12/01/1977 - "Cyclical thrombocytopenia with remission during lynestrenol treatment in a woman."

09/01/1969 - "1. Mestranol (oestrogen) prolonged, whilst lynestrenol (progestin) reduced, the duration of pentobarbitone and hexobarbitone sleep in mice, whilst the effects of barbitone were not altered.2. The effects of these steroids on pentobarbitone sleep were dose-related, did not show tachyphylaxis, and produced optimal effects after only 4 days pretreatment.3. The effects of lynestrenol were abolished by SKF 525A, whilst those of mestranol were markedly potentiated, suggesting a different mechanism and/or locus of action for mestranol and SKF 525A.4. Examination of plasma levels of pentobarbitone in mice pretreated with mestranol, lynestrenol or SKF 525A showed that lynestrenol increased whilst mestranol and SKF 525A reduced the rate of clearance of barbiturate from the plasma.5. The effects of lynestrenol disappeared when pentobarbitone was prevented from inducing hypothermia, whilst some significant prolongation of pentobarbitone sleep persisted in mestranol treated mice. "

07/01/2014 - "Comparison of the efficacy of micronized progesterone and lynestrenol in treatment of simple endometrial hyperplasia without atypia."