Lymphotoxin-alpha (Lymphotoxin)

A tumor necrosis factor family member that is released by activated LYMPHOCYTES. Soluble lymphotoxin is specific for TUMOR NECROSIS FACTOR RECEPTOR TYPE I; TUMOR NECROSIS FACTOR RECEPTOR TYPE II; and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14. Lymphotoxin-alpha can form a membrane-bound heterodimer with LYMPHOTOXIN-BETA that has specificity for the LYMPHOTOXIN BETA RECEPTOR.

Also Known As:

Networked: 1092 relevant articles (12 outcomes, 110 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fu, Yang-Xin: 20 articles (04/2014 - 06/2002)
2.	Browning, Jeffrey L: 11 articles (03/2014 - 07/2003)
3.	Ware, Carl F: 11 articles (11/2013 - 07/2004)
4.	Pfeffer, Klaus: 9 articles (04/2015 - 05/2003)
5.	Nedospasov, Sergei A: 9 articles (03/2011 - 02/2004)
6.	Hunt, Nicholas H: 7 articles (02/2016 - 09/2003)
7.	Grogan, Jane L: 7 articles (01/2014 - 07/2009)
8.	Hehlgans, Thomas: 6 articles (12/2014 - 05/2003)
9.	Young, Judy: 5 articles (09/2015 - 07/2009)
10.	Karin, Michael: 5 articles (05/2015 - 10/2009)

Related Diseases

1.	Infection 03/01/2006 - "Expression of CCL21 in lymphotoxin (LT)-alpha-deficient mice is dramatically reduced, however MCMV infection further reduced CCL21 levels, suggesting that viral modulation of CCL21 was independent of LTalpha signaling. " 11/15/2009 - "This indicates that neither TNF nor lymphotoxin, which uses the same receptor, was required in mediating protective heterologous immunity against VV. Indeed, prior immunity to LCMV made the role of TNF in protection against VV infection much less important, even under conditions of lethal dose inoculum. " 01/01/2015 - "Finally, Nfkb2 connected lymphotoxin signal within the intestinal niche in reinforcing epithelial innate inflammatory RelA/NF-κB response to Citrobacter rodentium infection, while Nfkb2(-/-) mice succumbed to gut infections owing to stromal defects. " 01/01/2013 - "To explore the role of organized intestinal lymphoid tissues in infection by and immunity to rotavirus, lymphotoxin alpha-deficient (LTα(-/-)) mice that lack Peyer's patches and mesenteric lymph nodes were orally infected with murine rotavirus. " 10/01/2012 - "Infection with Toxoplasma gondii alters lymphotoxin expression associated with changes in splenic architecture."
2.	Inflammation 06/01/2014 - "LIGHT signals through the lymphotoxin β receptor in the colon to regulate the innate immune response and mediate recovery from intestinal inflammation." 03/15/2014 - "Whereas the lymphotoxin pathway was critical for the induction of the B cell chemoattractant CXCL13 in response to Nod1 agonists, B cell accumulation within the spleen following Nod1-induced systemic inflammation was independent of the lymphotoxin pathway. " 03/01/2013 - "Lymphotoxin-alpha (LT-alpha or LTA) is an inflammatory cytokine that is involved in the organization and maintenance of the inflammatory process and in the arrangement of cells at the site of inflammation. " 01/01/2012 - "Lymphotoxin-sensitive microenvironments in homeostasis and inflammation." 01/01/2011 - "Lymphotoxin alpha (LTα) is the closest homolog to TNFα and has been implicated in inflammation and autoimmunity since its original description in 1968. "
3.	Melanoma (Melanoma, Malignant) 01/01/2002 - "Mice suffering from melanoma can be cured by treatment with a recombinant antibody-lymphotoxin-alpha fusion protein. " 02/01/2001 - "A recombinant antibody-lymphotoxin-alpha fusion protein induced an adaptive immune response protecting mice from melanoma. " 12/01/1985 - "The A375 melanoma cell line was also sensitive to another human cytokine alpha-lymphotoxin (alpha-LT) derived from a human B cell line. " 01/01/1981 - "To determine whether this increased SCMC activity is due to the production of a lymphokine and related to the production of a lymphotoxin(LT)-like mediator, PBL from normal controls and PBL and SFL from RA patients were incubated either with a human melanoma cell line (IGR 3) or with cell-free synovial fluid (SF) from RA patients. " 02/01/1976 - "Spontaneous cytotoxicity (SCMC) of normal human lymphocytes against a human melanoma cell line: a phenomenon due to a lymphotoxin-like mediator."
4.	Neoplasms (Cancer) 03/01/2014 - "Lymphotoxin-alpha (LTA) polymorphism rs909253 has been reported to be a risk factor for cancers, but some results are inconsistent. " 03/01/2014 - "Positive association between lymphotoxin-alpha variation rs909253 and cancer risk: a meta-analysis based on 36 case-control studies." 02/20/2014 - "A quantitative biodistribution analysis performed with radioiodinated protein preparations in tumor-bearing mice revealed that TRAIL and lymphotoxin alpha1/beta2 were able to selectively accumulate at the tumor site, while all other members of the TNF superfamily abrogated the selective tumor targeting performance of the parental antibody or accumulated also in healthy tissues. " 08/15/2013 - "Together, our results support a key role for DCs and DC-derived lymphotoxin in the formation of tumor HEVs. " 08/15/2013 - "We found that lymphotoxin β was overexpressed in tumors containing high densities of HEVs (HEV(high)) and correlated to DC-LAMP, a marker of mature DCs. "
5.	Fever (Fevers) 09/01/1988 - "The influence of TNF-beta and hyperthermia on the cell cycle was examined. " 09/01/1988 - "In vitro combined treatment with TNF-beta (10,000 U/ml) and hyperthermia (at 43 degrees for 60 min) synergistically inhibited the proliferation of the cells. " 09/01/1992 - "Tumor necrosis factor-beta induces sleep, fever, and anorexia." 01/01/1992 - "The magnitude of fever induced by I.V. and I.C.V. injection of TNF beta was significantly greater than that induced by TNF alpha. " 09/01/2007 - "In phase I clinical trial of recombinant human lymphotoxin alpha (rhLTalpha), indomethacin was premedicated to alleviate chill and fever. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Immunoglobulins (Immunoglobulin)
3.	infliximab (Remicade)
4.	Glutamic Acid (Glutamate)
5.	N-Methylaspartate (NMDA)
6.	Fc Receptors (Fc Receptor)
7.	Interleukin-6 (Interleukin 6)
8.	Interleukins
9.	Interleukin-10 (Interleukin 10)
10.	Interferon-gamma (Interferon, gamma)

Related Therapies and Procedures

1.	Vitrectomy
2.	Transplants (Transplant)
3.	Ligation
4.	Drug Therapy (Chemotherapy)
5.	Kidney Transplantation