Lymphopenia (Lymphocytopenia)

06/01/2009 - "Safety and efficacy of treatment using interleukin-2 in a patient with idiopathic CD4(+) lymphopenia and Mycobacterium avium-intracellulare."
05/01/2008 - "Further studies with different schedules and doses of IL-2 will be required to optimize the protective effect of IL-2 on irradiation-induced lymphocytopenia in humans."
05/01/2008 - "This preliminary study showed that low-dose IL-2 was sufficient to reduce, even though not to completely abrogate, RT-induced lymphocytopenia. "
11/01/2005 - "These studies suggest that IL-2 and lymphopenia are primary modulators of CD4(+)CD25(+) T(reg) cell homeostasis."
11/01/2005 - "Mouse studies showed that IL-2 therapy induced expansion of existent T(reg) cells in normal hosts, and IL-2-induced T(reg) cell expansion was further augmented by lymphopenia. "

01/01/2015 - "Taken together, the data documents that AKP-11 treatment cause milder and reversible lymphopenia with milder adverse effects while maintaining therapeutic efficacy similar to that observed with FTY720, thus indicating therapeutic potential of AKP-11 for treatment of MS and related autoimmune disorders. "
06/01/2003 - "FTY 720, which induces lymphopenia, has previously been shown to display protective effects in models of I-R. "
09/01/2011 - "Differences along the pharmacological pathways that mediate vascular leak and lymphopenia were demonstrated, suggesting that distinct S1P(1) mechanisms mediate the adverse effects and efficacy of fingolimod."
07/01/2003 - "In humans, FTY720 causes dose-dependent peripheral blood lymphopenia, a reduced incidence of acute rejection episodes and only one apparent adverse reaction - a negative chronotropic effect - particularly after the loading dose. "
02/01/2007 - "Results of this study suggest that FTY720 is effective at inducing a peripheral lymphopenia in cats without any toxic side effects. "

11/01/1997 - "Although highly efficacious in destroying the malignant B-cells, fludarabine also causes T-cell lymphopenia and immunosuppression. "
08/15/1995 - "In addition, immunologic deficits may persist even in patients in complete remission; lymphopenia, predominantly involving the CD4 population, is universal after fludarabine therapy. "
11/01/2003 - "In PsA fludarabine induces significant peripheral, but modest, synovial lymphopenia, and a trend towards improved clinical response."
09/01/1998 - "Fludarabine treatment of patients with severe, refractory RA resulted in significant lymphopenia, suppression of lymphocyte function, and clinical improvement in the high dose group. "
07/01/2012 - "All patients developed a fludarabine dose-dependent lymphocytopenia. "

04/01/2010 - "Lymphopenia occurred in 80% of patients, who needed more treatment pulses (P = 0.002) and thus larger total amounts of oral (P = 0.006) and intravenous (P = 0.02) cyclophosphamide to eventually achieve remission. "
02/16/1984 - "Sequential studies during such treatment showed that cyclophosphamide caused lymphopenia, particularly among T helper cells, resulting in a significant fall in the immunoregulatory (helper/suppressor) cell ratio. "
03/01/2012 - "Lymphopenia was induced by cyclophosphamide. "
01/01/2012 - "Finally, in mice with cyclophosphamide induced lymphopenia, the administration of P3 mAb accelerated the recovery of both CD4(+) and CD8(+) T cells. "
06/01/2010 - "Fischer 344 female rats were injected with cyclophosphamide (CY) as a lymphopenia (LP) model. "

01/01/2015 - "These factors include lymphopenia, renal biopsy results, and cytomegalovirus DNA levels detected by polymerase chain reaction. "
02/01/2013 - "sCD163 correlated with plasma EBV-DNA, and associated with B symptoms, stage, and lymphopenia. "
10/28/2010 - "In addition, macaques vaccinated with the VEEV DNA had reduced febrile reactions, lymphopenia, and clinical signs of disease postchallenge as compared to negative control macaques. "
06/10/2009 - "Congenic DRF.(f/f) rats are protected from type 1 diabetes (T1D) by 34 Mb of F344 DNA introgressed proximal to the gimap5 lymphopenia gene. "
01/15/2003 - "After 3 months, continued detection of pp65 antigenemia or CMV DNA in plasma or peripheral blood leukocytes and lymphopenia (fewer than 300 lymphocytes/mm(3)) were strong predictors of late CMV disease and death. "

06/15/2000 - "Together, these observations suggest that activation of T cells in vivo, presumably by alloantigens, predisposes the cells to spontaneous apoptosis, and this phenomenon is associated with lymphopenia. "
10/01/1989 - "The gene for the T lymphocyte alloantigen, RT6, is not linked to either diabetes or lymphopenia and is not defective in the BB rat."
11/01/1986 - "Immunologic abnormalities included absolute T-cell lymphopenia and markedly reduced in vitro lymphocyte responses to phytohemagglutinin and to alloantigen in the mixed lymphocyte reaction. "
11/01/1991 - "A number of T-cell abnormalities including lymphopenia, poor cell-mediated responsiveness to alloantigen, and an absence of an RT6+ T-cell subset are associated with disease susceptibility. "
12/01/1998 - "Anemia, lymphopenia, hypogammaglobulinemia, profound anti-F1 cytotoxicity, and the loss of cytotoxic potential against third party alloantigen is seen in acute lethal GVH disease. "

11/01/1995 - "Studies have shown that T cell depleting antibodies produce profound peripheral blood lymphopenia but they are less effective in depleting lymphocytes in the joint. "
12/01/1969 - "The anti-mouse and anti-guinea pig antilymphocyte sera (ALS) prepared for this study were shown to contain cytoxic and leucoagglutinating antibodies, and were capable of producing severe lymphopenia in these animals. "
12/01/2013 - "The complete blood count test showed a severe lymphopenia and anaemia, and the cat tested positive for feline immunodeficiency virus (FIV) antibodies by enzyme-linked immunosorbent assay. "
06/01/2013 - "Though treatment with T-cell depleting antibodies was associated with consecutive CD4+ T lymphopenia in the whole cohort, the number of patients who received T-cell depleting antibodies was comparable between PCP and control patients (p=0.754). "
02/01/2010 - "In SSc, the presence of antitopoisomerase and anti-U1 RNP antibodies and lymphopenia correlated with the higher IFN scores (P = 0.005, P = 0.001, and P = 0.004, respectively); a missense mutation in IFNAR2 was significantly associated with the IFN score. "

01/01/2014 - "The lymphopenia was neither triggered by caspase-dependent apoptosis nor macrophage-mediated clearance of T cells, nor diminished survival of naïve or recently activated T cells due to paucity of IL-7. "
09/01/2015 - "Studies administering higher lymphocyte doses and/or IL-7 should be considered to restore severe treatment-related lymphopenia in HGG. "
12/16/2010 - "The purpose of this study was to evaluate, in simian immunodeficiency virus-infected rhesus macaques, the relevance of IL-7 therapy as a means to overcoming IFN-α-induced lymphopenia. "
05/01/2006 - "These studies suggest an important role for interleukin-7 in the treatment of patients with lymphopenia."
09/01/2015 - "Severe lymphopenia was not accompanied by elevated serum interleukin-7 (IL-7) levels. "

08/01/1975 - "These studies indicated that hydrocortisone administration caused a transient lymphocytopenia by a preferential depletion of the recirculating portion of the intravascular lymphocyte pool"
04/01/2013 - "However, in the decreasing salinity experiments, lymphopenia, neutrophilia and monocytosis were observed in the peripheral blood without modification of the packed cell volume, plasma protein or plasma cortisol levels. "
08/01/2008 - "Cortisol levels are elevated in patients with RSV and Ebola, and cortisol was higher in SARS patients with lymphopenia before any steroid therapy. "
12/23/2006 - "During the journey the dolphins had an increased plasma concentration of cortisol, and lymphopenia, eosinopenia and mild neutrophilia, indicating a stress response. "
03/01/2006 - "Cortisol levels and lymphocytopenia seem not to be related. "

01/01/1995 - "Severe lymphocytopenia (< 1,000/microliters) was observed at all dose levels of 2-CdA. "
05/15/1994 - "Although responses to 2-CdA are durable in the majority of patients with HCL, the uncertain long-term consequences of the observed CD4+ lymphocytopenia suggest caution in the broad application of this therapy."
11/01/2002 - "The course of disease in our patient provides evidence for sustained therapeutic efficacy of 2-CDA in chronic plaque psoriasis in the absence of severe side effects except asymptomatic lymphopenia."
08/01/1999 - "2-CdA induces lymphocytopenia, which may explain the improvement in this patient's psoriasis."
01/01/1999 - "However, 2-CdA administration often results in severe neutropenia and lymphocytopenia both responsible for the infectious complications observed in these patients. "

04/01/2001 - "Despite the severe lymphopenia, the patient tolerated intensive chemotherapy well and at 18 months, remains in complete remission."
02/01/2007 - "Preclinical studies have shown that the induction of lymphopenia by chemotherapy or radiation can enhance the antitumor efficacy of several distinct, cell-based immunotherapeutic approaches. "
11/01/2011 - "Correlations between pre-treatment lymphopenia (lymphocyte count < 1,000/μl) and the occurrence of hematological toxicity and efficacy of first-line palliative chemotherapy were investigated. "
01/01/2011 - "This study suggests that lymphopenia could be an independent prognostic marker to predict unfavorable OS and PFS in patients with PTCL-NOS treated with anthracycline-containing chemotherapy and can be used to further stratify high-risk patients using IPI scores."
01/01/2011 - "The aim of this study was to evaluate whether lymphopenia at diagnosis would have an adverse effect on survival in patients with PTCL-NOS treated with anthracycline-containing chemotherapy. "

01/01/2014 - "Significant pretreatment lymphopenia may impact the outcomes of immunotherapy and deserves additional investigation."
01/01/2013 - "A prominent side effect of TMZ is induction of profound lymphopenia, which some suggest may be incompatible with immunotherapy. "
01/27/2003 - "Lymphocytopenia (grade 3-4 CTC) occurred in 48.5% (34 out of 70) fully monitored patients following TMZ and was present after immunotherapy in two patients. "
01/15/2010 - "Recent work has suggested that the lymphopenia period occurring after various immunosuppressive or chemotherapy treatments may provide an interesting opportunity for adoptive antitumor immunotherapy. "
03/01/2012 - "The objective of this study was to determine the effectiveness of tumor vaccine immunotherapy combined with immune reconstruction using tumor-bearing host immune cells in lymphopenia, and to investigate the role of tumor-bearing host T cells activated in vitro during immunotherapy. "

02/01/2002 - "An improved outcome for this otherwise fatal syndrome could be achieved with newborn screening for lymphopenia so that transplantation could be performed under favorable thymopoietic conditions."
10/01/2009 - "In this study, we investigated the relationship between CD4 lymphopenia and the development of posttransplant malignancy (PTM) after induction therapies in renal transplant recipients (RTR). "
12/01/2014 - "Those with severe disease were more likely to be neutropenic (P = .02), but otherwise did not differ by age (P = .27), hematopoietic stem cell transplant recipient status (P = .19), or presence of lymphopenia (P = .09). "
10/01/2014 - "Collectively, our results imply that any setting of T cell lymphopenia or reduced CD40 function, including B cell recovery following transplantation, will impact the naive B cell repertoire. "
06/01/2013 - "In conclusion, PCP risk was associated with higher age and related to both thymic functional impairment and long-lasting CD4+ T-lymphopenia that started already before transplantation. "

11/01/2014 - "Radiotherapy-induced lymphopenia was associated with poorer overall survival in patients with NSCLC treated with hypofractionated radiotherapy. "
11/01/2014 - "Radiotherapy can result in lymphopenia, which has been linked to poorer survival. "
01/01/2014 - "Ionizing radiation causes a series of hematological alterations especially profound lymphocytopenia during and after the radiotherapy course. "
01/01/2010 - "Lymphocyte counts before radiotherapy/TMZ of less than 1200/microl predict severe lymphopenia during radiotherapy/TMZ."
01/01/2010 - "Minimal lymphocyte counts during radiotherapy/TMZ and lymphocyte counts before radiotherapy/TMZ showed close linear correlation by linear regression analysis (p < 0.0001, R(2) = 0.569), and the most important predictor for CTC grade 4 lymphopenia was lymphocyte count before radiotherapy/TMZ less than 1200/microl by multivariate analysis (p < 0.0321, Exp = 13.2). "

10/15/2014 - "Oral administration of compound 10d to rats was shown to induce lymphopenia at 3 mg/kg."
01/01/2014 - "Oral administration of PAG quickly restored CP-induced lymphopenia and erythropenia in a dose-dependent manner. "
01/01/2011 - "The result obtained showed that handling, loading and transportation induced lymphopenia, neutrophilia, liveweight loss, and mortality, which was alleviated by oral administration of AA, E, and AA + E at doses of 60 mg, 30 mg, and 60 + 30 mg per kg bodyweight, respectively, 30 minutes before being loaded and transported. "
04/15/2009 - "Oral administration of the lead molecule 11c (PPI-4667) demonstrated potent and dose-responsive lymphopenia."
12/13/2007 - "After oral administration in mice, both compounds evoked lymphopenia, but their duration of action differed markedly."