Lymphogranuloma Venereum

Subacute inflammation of the inguinal lymph glands caused by certain immunotypes of CHLAMYDIA TRACHOMATIS. It is a sexually transmitted disease in the U.S. but is more widespread in developing countries. It is distinguished from granuloma venereum (see GRANULOMA INGUINALE), which is caused by Calymmatobacterium granulomatis.

Also Known As:

Networked: 214 relevant articles (4 outcomes, 24 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Urethritis
2.	Uterine Cervicitis (Cervicitis)
3.	Infection
4.	Neurosyphilis (General Paresis of the Insane)
5.	Hepatitis C

Experts

1.	Morré, Servaas A: 3 articles (12/2010 - 02/2008)
2.	de Vries, Henry J C: 3 articles (12/2010 - 02/2008)
3.	Borrego, Maria José: 2 articles (01/2014 - 12/2012)
4.	Ferreira, Rita: 2 articles (01/2014 - 12/2012)
5.	Borges, Vítor: 2 articles (01/2014 - 12/2012)
6.	Gomes, João Paulo: 2 articles (01/2014 - 12/2012)
7.	Ojcius, David M: 2 articles (01/2011 - 11/2004)
8.	Workowski, Kimberly A: 2 articles (12/2010 - 08/2006)
9.	Smelov, Vitaly: 2 articles (12/2010 - 03/2009)
10.	Pleijster, Jolein: 2 articles (12/2010 - 03/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lymphogranuloma Venereum:

1.	Azithromycin (Zithromax)FDA LinkGeneric 12/01/2003 - "Unusual presentation of early lymphogranuloma venereum in an HIV-1 infected patient: effective treatment with 1 g azithromycin." 01/01/1996 - "In both series, azithromycin treatment resulted in cure of both Haemophilus ducreyi culture-positive and culture-negative cases of GUD, including two cases subsequently diagnosed as lymphogranuloma venereum. " 08/04/2006 - "Included in these updated guidelines are an expanded diagnostic evaluation for cervicitis and trichomoniasis; new antimicrobial recommendations for trichomoniasis; additional data on the clinical efficacy of azithromycin for chlamydial infections in pregnancy; discussion of the role of Mycoplasma genitalium and trichomoniasis in urethritis/cervicitis and treatment-related implications; emergence of lymphogranuloma venereum protocolitis among men who have sex with men (MSM); expanded discussion of the criteria for spinal fluid examination to evaluate for neurosyphilis; the emergence of azithromycin- resistant Treponema pallidum; increasing prevalence of quinolone-resistant Neisseria gonorrhoeae in MSM; revised discussion concerning the sexual transmission of hepatitis C; postexposure prophylaxis after sexual assault; and an expanded discussion of STD prevention approaches." 12/17/2010 - "Included in these updated guidelines is new information regarding 1) the expanded diagnostic evaluation for cervicitis and trichomoniasis; 2) new treatment recommendations for bacterial vaginosis and genital warts; 3) the clinical efficacy of azithromycin for chlamydial infections in pregnancy; 4) the role of Mycoplasma genitalium and trichomoniasis in urethritis/cervicitis and treatment-related implications; 5) lymphogranuloma venereum proctocolitis among men who have sex with men; 6) the criteria for spinal fluid examination to evaluate for neurosyphilis; 7) the emergence of azithromycin-resistant Treponema pallidum; 8) the increasing prevalence of antimicrobial-resistant Neisseria gonorrhoeae; 9) the sexual transmission of hepatitis C; 10) diagnostic evaluation after sexual assault; and 11) STD prevention approaches." 04/01/2015 - "This article addresses factors that may be contributing to treatment failure for rectal chlamydia, including the pharmacokinetic properties of azithromycin and doxycycline in rectal tissue, the ability of chlamydia to transform into a persistent state that is less responsive to antimicrobial therapy, the impact of the rectal microbiome on chlamydia, heterotypic resistance, failure to detect cases of lymphogranuloma venereum and the performance of screening tests. "
2.	Chlortetracycline (Aureomycin)FDA Link 01/01/1953 - "[Treatment of lymphogranuloma inguinale with aureomycin]." 05/01/1952 - "[Aureomycin in the treatment of lymphogranuloma venereum; our experience in the gynecological clinic of the Faculdade de Medicina da Bahia]." 07/01/1951 - "Treatment of early lymphogranuloma venereum with aureomycin." 02/01/1951 - "Aureomycin therapy in lymphogranuloma venereum." 01/01/1951 - "Case of lymphogranuloma venereum treated with aureomycin."
3.	Immunoglobulin G (IgG)IBA 08/01/2008 - "He was diagnosed with lymphogranuloma venereum based on the histopathological findings and a high titre of IgG (1:1400)." 03/01/2006 - "Serum antibody titers for Chlamydia trachomatis were determined among 14 subjects and revealed strongly positive in 13 cases (1/512 to 1/16384) titers of IgG. These 22 patients with clinico-biologically confirmed anorectal lymphogranuloma venereum (ARLGV) were all homosexual men. " 07/01/2007 - "The use of serological titres of IgA and IgG in (early) discrimination between rectal infection with non-lymphogranuloma venereum and lymphogranuloma venereum serovars of Chlamydia trachomatis." 08/01/1983 - "Of 41 sera tested from patients with lymphogranuloma venereum, pelvic inflammatory disease, cervicitis, or urethritis there was a 90 and 63% correlation of positive results for IgG and IgM, respectively, by microimmunofluorescence and ELISA. " 11/01/1982 - "Rabbit immunoglobulin G (IgG) antibodies raised against the major outer membrane protein of the Chlamydia trachomatis lymphogranuloma venereum strain 434 neutralized the infectivity of the parasite for HeLa 229 cells. "
4.	Immunoglobulin M (IgM)IBA 08/01/1983 - "Of 41 sera tested from patients with lymphogranuloma venereum, pelvic inflammatory disease, cervicitis, or urethritis there was a 90 and 63% correlation of positive results for IgG and IgM, respectively, by microimmunofluorescence and ELISA. "
5.	Complement System Proteins (Complement)IBA 01/01/1963 - "All persons in the study were tested for lymphogranuloma venereum by the complement-fixation and Frei tests. " 09/01/1947 - "Studies on lymphogranuloma venereum; evaluation of the complement fixation test with lygranum." 05/01/1947 - "Studies on the complement fixation reaction in lymphogranuloma venereum." 06/01/1983 - "Histological examination of the rectal mass and a positive lymphogranuloma complement fixation test result confirmed the diagnosis of lymphogranuloma venereum. " 01/01/1977 - "The diagnosis of lymphogranuloma venereum was made by a fourfold rise in complement fixing antibody titer. "
6.	AntigensIBA 01/01/1997 - "Diagnosis of lymphogranuloma venereum was made by means of a positive immunofluorescence test (Total Ig titer of 1:512) and a positive detection of chlamydial antigens by ELISA in a semen sample. " 01/01/1996 - " The antigens were for Chlamydia trachomatis A-C (CTA-C), Chlamydia trachomatis D-K (CTD-K), Lymphogranuloma venereum (LGV 1-3), and C. " 02/01/1977 - "trachomatis protein antigen appears to be a useful serologic test for diagnosis of lymphogranuloma venereum." 02/01/1977 - "Serologic diagnosis of Lymphogranuloma venereum by counterimmunoelectrophoresis with a Chlamydia trachomatis protein antigen." 12/10/1949 - "Extraction of a specific antigen from the virus of lymphogranuloma venereum."
7.	Anti-Bacterial Agents (Antibiotics)IBA 04/07/1950 - "[Clinical use of chemotherapeutics and antibiotics in the treatment of ulcus molle and lymphogranuloma inguinale]." 11/01/1954 - "Rectal strictures of lymphogranuloma venereum; some observations from a five-year study of treatment with the broad spectrum antibiotics." 09/01/1953 - "The therapy of experimental psittacosis and lymphogranuloma venereum (inguinale) II. The activity of quinoxaline-1:4-dioxide and substituted and related compounds, with a note on the morphological changes induced in lymphogranuloma virus by these compounds and by antibiotics." 03/01/1953 - "The newer antibiotics in the treatment of rectal strictures of lymphogranuloma venereum." 12/30/1952 - "Antibiotics in treatment of lymphogranuloma venereum and granuloma inguinale."
8.	SolventsIBA 08/01/1948 - "Studies on lymphogranuloma venereum complement-fixing antigens; fractionation with organic solvents of antigens of the psittacosis-lymphogranuloma venereum group." 07/01/1947 - "Studies on lymphogranuloma venereum complement-fixing antigens; fractionation with organic solvents of antigens of the psittacosis lymphogranuloma venereum group."
9.	Doxycycline (Vibramycin)FDA LinkGeneric 02/01/2011 - "We present a series of 15 cases with lymphogranuloma venereum (LGV) with the aim of evaluating the response to a 21-day oral course of doxycycline (100mg twice daily). " 08/01/2010 - "Doxycycline failure in lymphogranuloma venereum." 03/01/2007 - "A diagnosis of lymphogranuloma venereum (LGV) was made and a three-week course of doxycycline was given. " 06/01/1968 - "[Study on doxycycline in the treatment of acute infections of the respiratory system and lymphogranuloma venereum]." 02/01/2012 - "Lymphogranuloma venereum and donovanosis are treated with 21 days of oral doxycycline. "
10.	Oxytetracycline (Terramycin)FDA Link 03/01/1953 - "Terramycin in early lymphogranuloma venereum." 05/01/1952 - "[Terramycin therapy of lymphogranuloma venereum]." 06/01/1951 - "The treatment of lymphogranuloma venereum with terramycin; report of twenty successfully treated cases." 10/01/1956 - "Intramuscular oxytetracycline (terramycin) in the treatment of chancroid, lymphogranuloma venereum, and granuloma inguinale." 09/01/1951 - "Terramycin in the treatment of chancroid, lymphogranuloma venereum, and granuloma inguinale."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/1957 - "Chemotherapy in bubonic lymphogranuloma venereum: a clinical and serological evaluation." 01/01/1950 - "[Chemotherapy of lymphogranuloma inguinale]." 07/01/1948 - "Chemotherapy of lymphogranuloma venereum." 06/01/1946 - "Studies on the chemotherapy of viruses in the psittacosis-lymphogranuloma venereum group; effect of certain chemotherapeutic agents on the growth of psittacosis virus (6BC strain) in tissues cultures and eggs." 07/01/1946 - "Studies on the chemotherapy of viruses in the psittacosis-lymphogranuloma venereum group; effect of certain chemotherapeutic agents on psittacosis virus (6BC strain) infections in mice."
2.	Aftercare (After-Treatment) 03/01/1956 - "Complement-fixation titres in tertiary lymphogranuloma venereum; a study of results after treatment with broad-spectrum antibiotics."
3.	Injections 06/01/1952 - "[Treatment of lymphogranuloma venereum by intracutaneous injections of lygranum]."
4.	Hysterectomy 06/01/1952 - "[Lymphogranuloma venereum of the abdominal wall following surgical incision for hysterectomy]."
5.	Enema (Enemas) 02/01/2008 - "Lymphogranuloma venereum proctitis in men who have sex with men is associated with anal enema use and high-risk behavior."