Lymphocytic Choriomeningitis

A form of meningitis caused by LYMPHOCYTIC CHORIOMENINGITIS VIRUS. MICE and other rodents serve as the natural hosts, and infection in humans usually occurs through inhalation or ingestion of infectious particles. Clinical manifestations include an influenza-like syndrome followed by stiff neck, alterations of mentation, ATAXIA, and incontinence. Maternal infections may result in fetal malformations and injury, including neonatal HYDROCEPHALUS, aqueductal stenosis, CHORIORETINITIS, and MICROCEPHALY. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)

Also Known As:

Networked: 149 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Persistent Infection
3.	Glomerulonephritis
4.	Viremia
5.	Proteinuria

Experts

1.	Botten, Jason: 4 articles (01/2018 - 12/2009)
2.	Watts, Tania H: 2 articles (12/2018 - 01/2018)
3.	Bruce, Emily A: 2 articles (01/2018 - 01/2018)
4.	King, Benjamin R: 2 articles (01/2018 - 01/2018)
5.	Ziegler, Christopher M: 2 articles (01/2018 - 01/2018)
6.	Buchmeier, Michael J: 2 articles (05/2010 - 12/2009)
7.	Bui, Huynh-Hoa: 2 articles (05/2010 - 12/2009)
8.	Grey, Howard: 2 articles (05/2010 - 12/2009)
9.	Kotturi, Maya F: 2 articles (05/2010 - 12/2009)
10.	Maybeno, Matt: 2 articles (05/2010 - 12/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lymphocytic Choriomeningitis:

1.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/01/1971 - "Cyclophosphamide-induced protection against acute lymphocytic choriomeningitis in mice." 10/01/1986 - "Bone marrow radiation chimeras have been used as virus-infected, cyclophosphamide-suppressed recipients to analyze the major histocompatibility complex (MHC) restriction constraints on the adoptive transfer of lymphocytic choriomeningitis by immune T cells. " 10/01/1985 - "Consequences of cyclophosphamide treatment in murine lymphocytic choriomeningitis: evidence for cytotoxic T cell replication in vivo." 02/01/1985 - "Participation of cyclophosphamide-resistant T cells in murine lymphocytic choriomeningitis." 02/01/1985 - "Adoptively transferred immune spleen cells induce fatal neurological disease in cyclophosphamide-suppressed recipients injected intracerebrally (ic) with a large, but not small, dose of neurotropic lymphocytic choriomeningitis (LCM) virus. "
2.	Glycogen Synthase Kinase 3IBA 02/16/2016 - "Injection of GSK-3 inhibitors in mice increased in vivo CD8(+) OT-I CTL function and the clearance of murine gamma-herpesvirus 68 and lymphocytic choriomeningitis clone 13 and reversed T cell exhaustion. "
3.	Messenger RNA (mRNA)IBA 07/01/1994 - "In the present study, injection of antiserum to IFN-alpha/beta prevented the development of lymphocytic choriomeningitis, was associated with the absence of detectable expression of early 2'-5' oligo-adenylate synthetase mRNA and coincided with viremia of lymphocytic choriomeningitis virus (LCMV) followed by establishment of a persistent infection. " 09/01/1985 - "Previous studies have reported that the 3' half of the small, S, RNA species of the WE strain of lymphocytic choriomeningitis (LCM) virus codes for the viral nucleoprotein in a subgenomic, viral-complementary, mRNA species (Romanowski, V. and Bishop, D.H.L. "
4.	AntigensIBA 01/01/1940 - "A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. CHARACTERISTICS OF THE ANTIGEN AND ITS USE IN PRECIPITIN REACTIONS." 06/30/1939 - "A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : I. SEPARATION OF SOLUBLE ANTIGEN FROM VIRUS." 01/01/2023 - "Both mixed bone marrow chimera and antigen-specific T cell adoptive cotransfer studies show a specific increase in Tfh cells among LXRβ-deficient CD4+ T cell population in response to immunization and lymphocytic choriomeningitis mammarenavirus (LCMV) infection. " 02/01/2001 - "In the first part of the present editorial [1], we recalled experimental and clinical data demonstrating that 1) UV, via their effects on Langerhans cells, and 2) some so-called immunodepressive viruses, such as measles, lymphocytic choriomeningitis agents, and some animal retroviruses, via their action on dendritic cells, can induce tolerance in some conditions concerning immunologic parameters and/or the antigen(s). " 11/19/1971 - "Persistent infection with lymphocytic choriomeningitis (LCM) virus activates a phenotypic expression of murine leukemia viruis-related antigen. "
5.	VaccinesIBA 01/01/1983 - "In adult mice with a normal immune system the vaccine only delayed the manifestation of fatal lymphocytic choriomeningitis, while it prevented its development in germfree mice with an underdeveloped lymphoid system, i.e. " 06/30/1938 - "IMMUNIZATION OF GUINEA PIGS AGAINST LYMPHOCYTIC CHORIOMENINGITIS WITH FORMOLIZED TISSUE VACCINES." 06/30/1938 - "Guinea pigs can be immunized against lymphocytic choriomeningitis by 2 or 3 injections with formolized vaccines prepared from a variety of infected guinea pig tissues. " 09/01/1991 - "Both, NDV vaccine and M pretreatments contributed to the development of fatal lymphocytic choriomeningitis, thus enhanced the cellular immune response to LCMV infection. " 01/01/1986 - "A single intraperitoneal treatment with live Newcastle Disease Virus (NDV) containing attenuated NDV vaccine, and with live infectious bursal disease virus (IBDV) containing attenuated IBDV vaccine, one day before intracerebral infection with lymphocytic choriomeningitis virus (LCMV) increased, whereas a similar treatment with inactivated NDV or IBDV vaccine did not influence the death rate of suckling mice from experimental lymphocytic choriomeningitis. "
6.	Antiviral Agents (Antivirals)IBA 01/01/1968 - "Further studies of antiviral activity of natural products on lymphocytic choriomeningitis infection." 12/01/2008 - "Intracranial infection of mice with lymphocytic choriomeningitis virus (LCMV) results in a lethal neurological disease termed lymphocytic choriomeningitis (LCM) that is mediated by antiviral CD8(+) T cells. " 01/01/1971 - "Lymphocytic choriomeningitis: an animal model of persistent viral infection with cellular injury mediated by host antiviral immune response." 05/01/1967 - "Antiviral activity of higher plants and propionin on lymphocytic choriomeningitis infection." 05/01/1966 - "Antiviral activity of higher plants on lymphocytic choriomeningitis infection in vitro and in vivo."
7.	RNA (Ribonucleic Acid)IBA 01/01/2018 - "We developed a high-throughput, smFISH assay and used it to quantitate lymphocytic choriomeningitis mammarenavirus (LCMV) replicative and transcriptional RNA species in individual cells at distinct time points following infection. " 06/01/2014 - "In mice persistently infected since birth with the prototypic arenavirus lymphocytic choriomeningitis viurs, viral antigen and RNA are readily detected in most organs and cell types but remarkably absent in skeletal muscle. " 06/01/1987 - "These results support the conclusion that in Tacaribe virus--as in Pichinde and lymphocytic choriomeningitis arenavirus-S RNA encodes the viral N and GPC proteins and has an 'ambisense' coding strategy. " 02/01/1985 - "Analyses of the 3' end sequences of the small, S, and large, L, RNA species of lymphocytic choriomeningitis (LCM) virus isolates ARM and WE, and DNA clones of LCM-WE, have shown that there are extensive RNA sequence homologies between the 3' ends of the two RNA species of both LCM strains. " 09/01/1985 - "Previous studies have reported that the 3' half of the small, S, RNA species of the WE strain of lymphocytic choriomeningitis (LCM) virus codes for the viral nucleoprotein in a subgenomic, viral-complementary, mRNA species (Romanowski, V. and Bishop, D.H.L. "
8.	NucleoproteinsIBA 12/01/2007 - "We have previously reported that lymphocytic choriomeningitis nucleoprotein (LCMV-NP) expressed in HEK cells (HEK-NP) induces cross-priming of CD8+ T cells in vivo. " 09/15/1994 - "A major portion of the nucleoprotein (amino acids 67 through 300) and the glycoprotein-2 of lymphocytic choriomeningitis (LCM) virus were synthesized by using recombinant technology and were injected together with SDS twice in portions of 5 micrograms into BALB/c mice. " 03/01/1989 - "Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia-recombinant virus expressing LCMV-WE nucleoprotein or glycoprotein." 09/01/1985 - "Previous studies have reported that the 3' half of the small, S, RNA species of the WE strain of lymphocytic choriomeningitis (LCM) virus codes for the viral nucleoprotein in a subgenomic, viral-complementary, mRNA species (Romanowski, V. and Bishop, D.H.L. " 01/01/1988 - "Of a total of 17 monoclonal antibodies (MAb) directed against structural proteins of the lymphocytic choriomeningitis (LCM) virus, 3 were specific for the viral nucleoprotein (p63) and attached to the plasma membrane of infected cells, as disclosed by the indirect immunofluorescence procedure and complement-mediated cytolysis. "
9.	EpitopesIBA 11/12/2001 - "Induction of specific CD8+ memory T cells and long lasting protection following immunization with Salmonella typhimurium expressing a lymphocytic choriomeningitis MHC class I-restricted epitope." 03/15/1998 - "The primary CTL response of BALB/c mice infected with the lymphocytic choriomeningitis (LCM) virus strain WE is directed exclusively against one major epitope, n118, whereas a viral variant, ESC, that does not express n118 induces CTL against minor epitopes. " 12/01/2009 - "The main hypothesis we tested in the present study was whether it is possible to design a universal vaccine strategy capable of inducing simultaneous HLA-restricted CD8+ T cell responses against 7 pathogenic arenaviruses (including the lymphocytic choriomeningitis, Lassa, Guanarito, Junin, Machupo, Sabia, and Whitewater Arroyo viruses), either through the identification of widely conserved epitopes, or by the identification of a collection of epitopes derived from multiple arenavirus species. " 04/01/2006 - "We tested whether a high concentration of Ag (GP33 peptide) would protect lymphocytic choriomeningitis (LCMV)-specific naive CD8 T cells (TCR transgenic P14 cells specific for the GP33 epitope of LCMV) and memory CD8 T cells (GP33-specific LCMV-immune cells) from depletion. " 01/01/2020 - "Our current understanding of MHC I-restricted epitopes come from the observance of CD8+ T cell responses against viral (vaccinia, lymphocytic choriomeningitis etc.) and model (chicken ovalbumin, hen egg lysozyme etc.) antigens. "
10.	Monoclonal AntibodiesIBA 12/01/1989 - "Impaired generation of anti-viral cytotoxicity against lymphocytic choriomeningitis and vaccinia virus in mice treated with CD4-specific monoclonal antibody." 08/01/1981 - "Monoclonal antibodies to lymphocytic choriomeningitis and pichinde viruses: generation, characterization, and cross-reactivity with other arenaviruses." 01/01/1989 - "Monoclonal antibodies (mAb) with specificity for the T cell-associated serine proteinase-1 of the mouse (MTSP-1) were used to study expression and storage of this enzyme in T lymphocytes during lymphocytic choriomeningitis (LCM) virus infection in vivo. " 01/01/1988 - "Of a total of 17 monoclonal antibodies (MAb) directed against structural proteins of the lymphocytic choriomeningitis (LCM) virus, 3 were specific for the viral nucleoprotein (p63) and attached to the plasma membrane of infected cells, as disclosed by the indirect immunofluorescence procedure and complement-mediated cytolysis. "

Therapies and Procedures

1.	Therapeutics 03/12/2013 - "To describe the pathogenesis and significance of viral infection in terms of host responses, resultant injury, and therapy, we focused on two RNA viruses: lymphocytic choriomeningitis (LCMV) and influenza (Flu). "
2.	Intraperitoneal Injections 01/01/1975 - "Intraperitoneal injection of nononcogenic lymphocytic choriomeningitis (LCM) virus in adult C3H mice causes a symptomless infection but stimulates specific cell-mediated and humoral immune responses. "
3.	Injections 06/30/1938 - "Guinea pigs can be immunized against lymphocytic choriomeningitis by 2 or 3 injections with formolized vaccines prepared from a variety of infected guinea pig tissues. "
4.	Immunotherapy 01/01/1964 - "PASSIVE IMMUNOPROPHYLAXIS AND IMMUNOTHERAPY OF INHALATION LYMPHOCYTIC CHORIOMENINGITIS IN GUINEA-PIGS."