Lymphedema (Milroy Disease)

01/01/2013 - "These results suggested that VEGF-C and ESWT had a synergistic effect and were very effective in alleviating the symptoms of lymphedema and promoting lymphangiogenesis."
05/01/2008 - "Compared with control group, overexpression of VEGF-C enhanced lymphangiogenesis in vivo and mouse tail skin suffering chronic obstructive lymphedema was improved by VEGF-C gene significantly. "
07/01/2015 - "As a precursor to future clinical trials, the therapeutic efficacy and blood vascular side effects of VEGF-C and VEGF-C156S were compared in a large animal model of secondary lymphedema. "
05/01/2008 - "To study the therapeutic effect of vascular endothelial growth factor C (VEGF-C) gene for chronic obstructive lymphedema in mouse tail model which may provide a new treatment for lymphedema. "
07/01/2011 - "Exogenous VEGF-C augments the efficacy of therapeutic lymphangiogenesis induced by allogenic bone marrow stromal cells in a rabbit model of limb secondary lymphedema."

10/01/2013 - "We performed a retrospective analysis of 107 BCRL patients to identify the efficacy of CDP and the predictors of lymphedema severity and response to CDP. "
03/15/2004 - "With a decrease in lymphedema of 60%, CDP may provide relief for patients with lymphedema following groin dissection. "
02/01/2015 - "The aim of this study was to analyze our experience with the treatment of male genital lymphedema and to describe our integrated concept, which combines perioperative complex decongestive physiotherapy (CDP) with surgical reduction. "
12/01/2007 - "In a study of Japanese women with lymphedema, CDP comprising a two-phase treatment program was clearly effective."
03/01/2000 - "Because little is known of its possible mode of action on a molecular level, this preliminary study evaluated CDP in patients with peripheral leg lymphedema as to the potential role of gene expression in the inflammatory response. "

03/01/1999 - "In both groups, the volume of arm lymphedema decreased (14.9% in Group A and 13.2% in Group B) (N.S.), the overall clinical score improved (12.9 +/- 4.3 to 5.7 +/- 3.5 in Group A and from 11.7 +/- 3.7 to 4.7 +/- 3.9 in Group B) (N.S.), and the overall efficacy of coumarin was similarly good or excellent (71.9% in Group A and 68.6% in Group B) (N.S.). "
01/01/1990 - "A randomized double blind study versus placebo has confirmed the occurrence of significant improvement of these mild swelling cases, and recommend the use of coumarin as supplemental therapy in mild lymphedema."
01/01/2005 - "However, it seems without doubt that the majority of studies conducted thus far suggest that coumarin (and other benzopyrones, i.e., the ruto-sides, which do not have hepatotoxic effects and which are often discussed in aggregate with coumarin) is effective in treating lymphedema, particularly when used in conjunction with complex physical therapy. "
02/04/1999 - "Coumarin has been reported to be effective for the treatment of women with lymphedema; we undertook a study in which we attempted to replicate those findings. "
09/01/1996 - "A study was performed on the use of an ideal phlebolymphological association (Tonka Beans, Gingko Biloba, Melilotus Officinalis) as a practical standpoint in the treatment of lymphedema of lower limbs in order to create an efficacious dose of Coumarin, Benzopyrones and Ginkolidi. "

05/01/2013 - "Although lymphedema can be cured by anastomosis of a lymph vessel (LV) to a vein, the operative procedure is extremely difficult because LNs and LVs are too small and indistinct to be identified. "
11/01/2014 - "In all cases, a lymphatic vessel that caused an intractable lymphorrhea was successfully anastomosed to a recipient vessel (to an intact lymphatic vessel in one case, and to a venule in three cases), and the lymphorrhea was completely cured without lymphorrhea recurrence or lymphedema development. "
10/01/2008 - "Defects in its formation or disruption of the vessels result in lymphedema, the effective treatment of which is hampered by limited understanding of factors regulating lymph vessel formation. "
02/01/2015 - "Our findings in this large set of patients undergoing autologous lymph vessel Tx to an upper limb confirm that this microsurgical technique significantly and persistently improves lymph drainage in patients with lymphedema. "
06/01/2013 - "Obvious damage to the lymph vessels was found in all of the 36 lower extremity lymphedema cases with different lengths of history, including vessel disruption in 21 and lymphatic regeneration in 15. "

09/01/2005 - "A significant reduction of lymphedema occurred in the sodium selenite-treated group. "
06/01/2007 - "Schrauzer, Treatment of secondary lymphedema of the arm with physical decongestive therapy and sodium selenite: a review, Am. J. "
05/01/2003 - "Additionally, our results suggest that sodium selenite has a positive effect on secondary-developing lymphedema caused by radiation therapy alone or by irradiation after surgery."
08/01/2000 - "Treatment of secondary lymphedema of the arm with physical decongestive therapy and sodium selenite: a review."
09/15/1997 - "Intensive treatment with decongestive physical therapy in combination with sodium selenite shows significant improvement in the reduction of the volume of the limb and in the histophysiology of secondary lymphedema after mastectomy or Wertheim-operation. "

01/01/2012 - "Indocyanine green (ICG) lymphography is superior to lymphoscintigraphy for diagnostic imaging of early lymphedema of the upper limbs."
01/01/2015 - "Indocyanine green (ICG) lymphography has been reported to be useful for the evaluation of secondary lymphedema, but no study has reported characteristic findings of ICG lymphography in primary lymphedema. "
05/01/2011 - "The purpose of this study was to describe, analyze, and classify characteristic indocyanine green lymphography findings to uniformly guide surgical management of lymphedema using this modality. "
11/01/2015 - "Correlation between indocyanine green (ICG) patterns and real-time elastography images in lower extremity lymphedema patients."
01/01/2015 - "Indocyanine Green Lymphography Findings in Primary Leg Lymphedema."

08/01/2006 - "The modified Charles procedure for the treatment of penoscrotal lymphedema is easily reproducible and allows better local hygiene, easier ambulation, voiding in the standing position, resuming sexual intercourse, and finally, better cosmetic results in the affected area with remarkable improvement in quality of life."
05/01/2005 - "Even medical management of penoscrotal lymphedema is not effective for most patients, surgery is a safe and effective procedure that gives excellent functional and cosmetic results."
07/01/2015 - "We report a case of a 27-year-old male with primary lymphedema complicated by large painful ENV lesions on his left foot that we excised surgically with good functional and cosmetic results as validated by the patient. "
09/01/2013 - "Adipose-derived stem cells were harvested from human lipoaspirate of the upper extremity from age-matched patients with lymphedema (n = 3) or subcutaneous adipose tissue from control patients undergoing cosmetic procedures (n = 3). "
04/01/2007 - "Penile and scrotal lymphedema causes significant functional, cosmetic and psychological problems. "

05/01/2007 - "SIR was replaced with Prograf with significant improvement in the lymphedema over the next 6 months. "
05/01/2015 - "Although no change in lymphedema was observed after 21 months despite dosage reduced, it improved markedly after changeover to tacrolimus. "
05/01/2015 - "[Sirolimus-induced lymphedema in a kidney-transplant recipient: Partial recovery after changeover to tacrolimus]."

12/01/1981 - "Lymphangiography, using oily radiopaque Lipiodol Ultra Fluid has been shown to increase lymphedema in one-third of the patients with obstructive lymphedema and to cause lymphatic obliteration (demonstrated histologically). "
12/01/1981 - "Allergy is another possible contributor, but the evidence from this series suggests that Lipiodol may act as a direct irritant when it is not rapidly cleared, as in the case of obstructive lymphedema, and proceed to obliteration of the residual lymphatics. "
12/01/2012 - "Lipiodol leak to the scrotum was observed in patients no. 2 and 3. Lymphaticopelvic fistula and genital lymphatic hyperplasia were seen in patient no. 1. Genital lymphedema diminished within 1 week and almost disappeared in two cases (patients no. 1 and 3) or significantly improved (patient no. 2). "

12/01/2011 - "A total of 1115 titles were indentified from the databases; 1109 obvious irrelevant studies were excluded by examining the titles, abstracts, full texts because of duplicates, no RCT, different modality of drainage, drain for lymphedema, application of fibrin sealant and so on. "
07/01/2008 - "A randomized phase III trial of VH fibrin sealant to reduce lymphedema after inguinal lymph node dissection: a Gynecologic Oncology Group study."
07/01/2008 - "VH fibrin sealant in inguinal lymphadenectomies does not reduce leg lymphedema and may increase the risk for complications in the vulvar wound."
07/01/2008 - "To evaluate VH fibrin sealant's influence on lower extremity lymphedema after inguinal lymphadenectomy in vulvar cancer patients. "
11/01/2014 - "Our aim was to assess the efficacy of a new low-thrombin fibrin glue in reducing the serous output from the axillary surgical wound in patients undergoing axillary node dissection for breast cancer, and its long-term effects on lymphedema. "

03/01/2015 - "According to Campis evaluation standard to assess efficacy, the results were excellent in 3 cases, good in 6 cases, and improved in 2 cases n Using modified side-to-end lymphaticovenular anastomosis may be effective in the treatment of upper limb lymphedema after mastectomy."
06/01/2013 - "Our results demonstrate that Phase I CDT treatment is very effective for post mastectomy lymphedema, and particularly if it is provided in earlier stages of disease. "
09/01/2015 - "Therefore, the results of this study showed that the CDT with a home program is an effective treatment for reducing post mastectomy lymphedema. "
10/01/2011 - "CDT combined with long-term self management is effective in treating post mastectomy lymphedema. "
05/01/2015 - "Efficacy of manual lymphatic drainage and intermittent pneumatic compression pump use in the treatment of lymphedema after mastectomy: a randomized controlled trial."

06/01/2011 - "Results document a significant improvement in quality of life and underscore success of autologous lymphatic vessel transplantation as a therapy for lymphedema."
03/01/2006 - "LN transplantation is a safe procedure permitting good long-term results, disappearance, or a noteworthy improvement, in postmastectomy lymphedema, especially in the early stages of the disease."
09/01/1994 - "We evaluated the use of transplantation of the greater omentum in the management of chronic lymphedema in 21 patients. "
10/01/1985 - "Experimental autologous lymphatic duct transplantation is technically feasible and therapeutically effective in the treatment of chronic lymphedema of the extremity. "
12/01/2013 - "The presented vascularized lymph node flap can be applied to transplantation studies, lymphedema studies, and to studies on immunological mechanism of tolerance and rejection."

10/01/2014 - "Although there is a significant reduction in the lymphedema rate with sentinel lymph node biopsy compared to axillary lymph node dissection, there is some risk after sentinel lymph node biopsy. "
03/01/2007 - "In conclusion, this questionnaire survey suggested that leaving the retroperitoneum open after lymphadenectomy is significantly effective in reducing the incidence of leg lymphedema, which impairs patients' quality of life more than expected by physicians."
09/01/2006 - "This surgical modality is effective in preventing lymphedema in lower extremities after intrapelvic para-aortic lymph node dissection."
10/01/2015 - "The aim of this study was to confirm a causal relationship between removal of circumflex iliac nodes to the distal external iliac nodes (CINDEIN) and lower-extremity lymphedema after systematic lymphadenectomy in patients with uterine corpus malignancies. "
08/01/2015 - "This study demonstrates a 19.7 percent incidence of lymphedema following axillary lymphadenectomy. "

12/01/2009 - "This pilot study explored the feasibility of conducting a larger trial to investigate whether the early use of compression stockings is effective in preventing leg lymphedema. "
02/01/2014 - "Efficacy of a short course of complex lymphedema therapy or graduated compression stocking therapy in the treatment of post-thrombotic syndrome."
09/01/1996 - "To assess the efficacy of compression therapy alone, we report herein the long-term results of leg lymphedema using elastic stockings. "
12/01/2015 - "Additional testing and recommendations were made in 49/54 (90.7%) e-consults, including lower-extremity venous duplex ultrasonography with reflux testing, duplex ultrasonography of the carotid artery, computed tomography, magnetic resonance imaging, non-invasive physiology arterial studies, laboratory tests, medications, compression stockings, and sequential lymphedema compression therapy. "
02/01/2014 - "We found a short course of lymphedema therapy and compression stockings offer similar benefit in patients with PTS; however, larger studies are needed to further explore the potential use of CLT in PTS, particularly in patients with more severe disease. "

07/01/2009 - "Although currently there is no single treatment proven effective for lymphedema in every patient, suction-assisted lipectomy has been shown to be effective in some patients. "
12/01/2015 - "Liposuction is a safe and effective option for carefully selected patients with advanced lymphedema. "
07/01/2006 - "Ultrasonic assisted liposuction combined with elastic compression is safe and effective for the treatment of primary limb lymphedema."
01/01/2009 - "Treatment of upper limb lymphedema with combination of liposuction, myocutaneous flap transfer, and lymph-fascia grafting: a preliminary study."
12/01/2015 - "Eligibility criteria for liposuction included (i) unilateral, non-pitting, International Society of Lymphology stage II/III lymphedema; (ii) limb volume difference greater than 25 %; and (iii) previously ineffective conservative therapies. "