Ludwig's Angina (Ludwigs Angina)

Severe cellulitis of the submaxillary space with secondary involvement of the sublingual and submental space. It usually results from infection in the lower molar area or from a penetrating injury to the mouth floor. (From Dorland, 27th ed)

Also Known As:

Networked: 55 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Vomiting
2.	Nausea
3.	Exanthema (Rash)
4.	Diarrhea
5.	Infection

Experts

1.	Aryal, Madan Raj: 1 article (01/2015)
2.	Chu, Yum-Kung: 1 article (01/2015)
3.	Pathak, Ranjan: 1 article (01/2015)
4.	Karmacharya, Paras: 1 article (01/2015)
5.	Supplee, Suzanne: 1 article (01/2015)
6.	Shen, Shu-Huei: 1 article (01/2015)
7.	Li, Wing-Yin: 1 article (01/2015)
8.	Yang, Rong-Hsin: 1 article (01/2015)
9.	Mukherjee, Soma: 1 article (05/2013)
10.	Maru, Laxmi: 1 article (05/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ludwig's Angina:

1.	Clavulanic Acid (Potassium Clavulanate)FDA LinkGeneric 03/01/1992 - "Treatment was discontinued in one loracarbef-treated patient because Ludwig's angina, unrelated to the study drug, was diagnosed and in five amoxicillin/clavulanate-treated patients because of diarrhea (two patients), rash (two patients), and nausea and vomiting (one patient). "
2.	Amoxicillin (Wymox)FDA LinkGeneric 03/01/1992 - "Treatment was discontinued in one loracarbef-treated patient because Ludwig's angina, unrelated to the study drug, was diagnosed and in five amoxicillin/clavulanate-treated patients because of diarrhea (two patients), rash (two patients), and nausea and vomiting (one patient). "
3.	loracarbef (Lorax)FDA Link 03/01/1992 - "Treatment was discontinued in one loracarbef-treated patient because Ludwig's angina, unrelated to the study drug, was diagnosed and in five amoxicillin/clavulanate-treated patients because of diarrhea (two patients), rash (two patients), and nausea and vomiting (one patient). "
4.	Anti-Bacterial Agents (Antibiotics)IBA 12/01/2006 - "In the preantibiotic era, Ludwig angina was frequently fatal; however, antibiotics and aggressive surgical treatment have significantly lowered mortality." 08/01/2003 - "In the pre-antibiotic era, Ludwig's angina was frequently fatal; however, antibiotics and aggressive surgical intervention have significantly reduced mortality. " 11/01/1980 - "Thus, aggressive management of Ludwig's angina, with respect to airway, antibiotics, and early surgical intervention, has resulted in a significant drop in the mortality rate of this disease which once led "almost uniformly to a fatal ending."" 07/01/2012 - "The appropriate use of parenteral antibiotics, airway protection techniques, and formal surgical drainage of the infection remains the standard protocol of treatment in advanced cases of Ludwig's angina." 03/01/2000 - "Despite the availability of antibiotics deep neck space infections with anaerobic germs (Ludwig's angina) still carry the potential for significant morbidity and mortality with delayed treatment. "
5.	Penicillins (Penicillin)FDA Link 02/01/1983 - "A fatal case of Ludwig's angina is reported in which penicillin was used as the sole antibiotic. " 01/01/1950 - "[Ludwig's angina treated with penicillin]." 09/01/1949 - "[Use of penicillin in a grave case of Ludwig's angina]." 06/01/1945 - "The Use of Penicillin in Ludwig's Angina."
6.	Warfarin (Coumadin)FDA LinkGeneric 02/01/2011 - "Warfarin-induced sublingual hematoma mimicking Ludwig angina: Conservative management of a potentially life-threatening condition." 01/01/2015 - "Warfarin induced sublingual hematoma: a Ludwig angina mimic." 04/01/2013 - "Sublingual hematoma secondary to short-acting anticoagulants such as warfarin has been labeled "pseudo-Ludwig's angina" to distinguish it from the classic syndrome of localized infection and swelling involving the upper airway. "
7.	Lidocaine (Xylocaine)FDA LinkGeneric 08/01/2001 - "There were eight 'other' complications suffered by 11 patients: necrotising fasciitis (n=l), herpes zoster (n=l), Ludwig's angina (n=l), infections of the submandibular (n=l), parapharyngeal (n=2), masticator (n=2) and submasseteric spaces (n =2), and reaction to local anaesthesia (2ml of 2 per cent lignocaine hydrochloride) (n=1). "
8.	Factor VIII (Coagulation Factor VIII)IBA 07/01/1985 - "This report describes the management of Ludwig's angina in a patient with severe classical hemophilia with a high titer of inhibitors to factor VIII." 07/01/1985 - "Management of Ludwig's angina in a patient with severe hemophilia A with factor VIII inhibitors: report of case."
9.	DNA (Deoxyribonucleic Acid)IBA 11/01/2001 - "Lateral pharyngeal space abscess was the most common DNA (43%), followed by submandibular space abscess, Ludwig's angina, and retropharyngeal space abscess (28%, 17%, and 12%, respectively). "
10.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 12/10/1949 - "[Favorable evolution of Ludwig's angina treated with high doses of ascorbic acid]."

Therapies and Procedures

1.	Airway Management 02/01/2011 - "Charts were studied for age, presence of true Ludwig angina, presence of airway compromise, airway management, morbidity/mortality, and the requirement for surgical airway. " 01/01/2011 - "Recently, management of Ludwig's angina has evolved from aggressive airway management into a more conservative one. " 06/01/2004 - "All patients with Ludwig's angina who received medical, metabolic, airway management, and surgical treatment from January 1, 1983 to December 31, 2000. " 12/01/1999 - "Airway management in Ludwig's angina." 05/01/1999 - "Ludwig angina: a review of current airway management."
2.	Tracheotomy 11/01/2001 - "Tracheotomy is indicated in patients with Ludwig's angina." 11/01/2001 - "Seventy-five percent of patients with true Ludwig's angina underwent tracheotomy. " 10/01/1994 - "Tracheotomy for Ludwig's angina." 07/01/1953 - "Ludwig's angina; report of a case requiring tracheotomy." 12/01/2008 - "The objectives of our cases presentation are to avoid mouth examination of Ludwig's angina if we are not ready for performing tracheotomy and to be aware of the possible development of disseminated intravascular coagulation and post decannulation emphysema."
3.	Tracheostomy 06/01/1985 - "A re-evaluation of the role of tracheostomy in Ludwig's angina." 08/01/1974 - "Ludwig's angina: use of fiberoptic laryngoscopy to avoid tracheostomy." 10/01/2003 - "[Selective ventilation via tracheostomy in a patient with mediastinitis and Ludwig's angina]." 07/01/1999 - "Because airway control still remains a top priority in Ludwig's angina, feasible options of airway control should be prepared before induction of anesthesia if tracheostomy was required in a patient with this disease." 07/01/1999 - "A 71-year-old woman with cellulitis of the floor of the mouth, referred to as "Ludwig's angina", underwent emergency tracheostomy under general anesthesia, for the control of airway narrowing caused by sublingual and submandibular swelling with tongue elevation. "
4.	Surgical Decompression 06/01/1985 - "Ten cases of Ludwig's angina that required surgical decompression in addition to intravenous antibiotic therapy are reviewed. " 11/01/1975 - "A severe case of Ludwig's Angina which was treated along the historical lines of surgical decompression is presented. " 03/01/2011 - "Does surgical decompression in Ludwig's angina decrease hospital length of stay?"
5.	Anesthesia 01/01/2008 - "Awake fiberoptic intubation under topical anesthesia may be the ideal method to secure the airway in advanced cases of Ludwig's angina. " 04/01/1953 - "MORBIDITY conference; anesthesia in Ludwig's angina." 07/01/1999 - "Because airway control still remains a top priority in Ludwig's angina, feasible options of airway control should be prepared before induction of anesthesia if tracheostomy was required in a patient with this disease."