Luciferases

Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.

Also Known As:

Networked: 3805 relevant articles (59 outcomes, 293 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gambhir, Sanjiv S: 17 articles (09/2012 - 03/2002)
2.	Curiel, David T: 16 articles (11/2013 - 11/2002)
3.	Nishikawa, Makiya: 16 articles (09/2013 - 11/2004)
4.	Lang, Florian: 15 articles (01/2015 - 08/2009)
5.	Burbelo, Peter D: 14 articles (02/2015 - 01/2008)
6.	Hashida, Mitsuru: 13 articles (09/2013 - 11/2004)
7.	Chen, Xiaoyuan: 13 articles (06/2013 - 11/2006)
8.	Wang, Lei: 11 articles (12/2014 - 03/2008)
9.	Yamashita, Fumiyoshi: 11 articles (09/2013 - 11/2004)
10.	Iadarola, Michael J: 11 articles (01/2012 - 01/2008)

Related Diseases

1.	Neoplasms (Cancer) 07/18/2003 - "This assay has been used for a pilot screen of 2800 compounds from the Cancer Research-UK collection, identifying five compounds showing a consistent significant reduction of MYCN-dependent luciferase activity (>50%) in repeated screens. " 03/22/2004 - "This study shows that in vivo imaging of luciferase-transfected tumour cells is a useful tool to investigate the dynamics of disseminated tumour growth and efficacy of anticancer treatment in orthotopic models of peritoneal cancer in rats. " 08/01/2010 - "Two different bioluminescent mouse cancer models demonstrate the utility of a new red-shifted thermostable luciferase, Ppy RE-TS, that improved the in vivo imaging performance when compared with wild-type P. " 01/01/2016 - "To demonstrate the efficacy of using an adenoviral vector for the detection of NE tumors, we have constructed a pair of adenoviral vectors which, in combination, can conditionally replicate and release Gaussia luciferase into the circulation after infecting the NE tumors. " 01/01/2014 - "In vivo, efficacy of bioconjugates or free drugs against luciferase-transduced tumor cells was assessed by bioluminescence optical imaging, and by recording mice survival. "
2.	Infection 04/01/2007 - "Analysis of five recombinant replicative adenoviruses with promise for clinical application showed that Ad5/3-Delta24 produced the most luciferase release 1 week after infection and achieved the earliest and highest peak luciferase release level. " 01/01/2009 - "cruzi induced a significant reduction of luciferase level for both pseudotypes in all the infection schemes (p<0.001), T. " 03/01/2005 - "In short, this luciferase imaging study is useful to monitor the efficacy of anti-leishmanial drugs on live cell culture and to trace leishmanial infection in animal models." 04/01/2013 - "The improved sensitivity of the luciferase reporter also facilitated time of addition studies validating the utility of this system for characterizing the early steps of HCV infection. " 12/01/2009 - "Here, we describe for the first time and validate the use of a luciferase-tagged recombinant Mycobacterium bovis BCG for non-invasive bioluminescent imaging of 1) bacterial dissemination in tissues, 2) the efficacy of treatment with anti-mycobacterial drugs and 3) the role of adaptive immune responses in controlling mycobacterial infection in vivo."
3.	Anoxia (Hypoxia) 08/17/2007 - "The addition of MT into the cultures of H9c2 cells relieved the HG suppression of hypoxia-induced luciferase activity. " 05/01/2000 - "Mutation in this sequence eliminated both the hypoxia-induced HIF-1 binding and luciferase expression. " 06/15/2015 - "Our studies showed EPO-mediated activation of HIF-1α led to subsequent binding of HIF-1α to hypoxia response elements (HREs) within the PlGF promoter, as demonstrated by luciferase transcription reporter assays and ChIP analysis of the endogenous gene. " 01/15/2011 - "In this study, we use transgenic mice expressing luciferase under the control of NF-κB to demonstrate that hypoxia activates NF-κB in the heart and lungs of mice in vivo. " 10/01/2002 - "Studies using luciferase reporter constructs revealed a significant increase in activity in cells subjected to hypoxia, which was lost in truncated constructs lacking the HIF-1 site. "
4.	Neoplasm Metastasis (Metastasis) 08/01/2015 - "The study used 2-photon microscopy to map the presence/distribution of fluorescently labeled, quiescent cells and luciferase expression to determine the presence of growing bone metastases. " 06/20/2015 - "The in vivo mouse model using orthotopically xenografted CWR22Rv1 cell line transfected with luciferase-reporter confirmed in vitro cell line studies showing TR4 increased PCa metastasis via decreasing the miR-373-3p expression. " 02/15/2015 - "Finally, the orthotopic xenografted mice studies using the luciferase expressing CWR22Rv1 cells found that TR4 enhanced PCa metastasis and this increased metastasis was reversed when the CCR2 antagonist was injected into the mice. " 01/01/2014 - "The aim of the study was to understand the role of BTK in myeloma cell growth and metastasis using the stably BTK knockdown luciferase-expressing INA6 myeloma line. " 01/01/2013 - "While these studies were facilitated by monitoring post-surgical spontaneous metastases using whole body bioluminescence imaging, we observed that the luciferase-tagged parental line showed altered growth and diminished metastatic properties compared to its untagged counterpart. "
5.	Breast Neoplasms (Breast Cancer) 10/01/2015 - "In the present study, miR-205 was significantly downregulated in breast cancer samples and it was identified to directly target the 3'-untranslated region (3'-UTR) of AMOT in breast cancer MCF-7 cells by luciferase assay. " 12/01/2013 - "The present study investigated the total estrogenic activity of fruits and vegetables by calculating the 17-β-estradiol equivalent quantity (EEQ) using two in vitro tests: the human breast cancer cell line (MCF-7 BUS) proliferation assay (E-screen test) and the luciferase-transfected human breast cancer cell line (MELN) gene-reporter assay. " 06/01/2012 - "The aim of this study was to establish a bioluminescent MDA-MB-231 cell line stably expressing luciferase and green fluorescent protein for the generation of a xenografted model of human triple-negative breast cancer (TNBC) in nude mice. " 03/06/2007 - "In comparison, the interaction of hGH with the same receptor ECD did not demonstrate any significant dependence on pH. We also present an initial investigation of the pH dependence of hPRL function in rat Nb2 cell proliferation assays and a STAT5 luciferase gene reporter assay in the T47D human breast cancer cell line, whose results are consistent with our biophysical studies. " 05/01/2001 - "MDA-MB-435 breast cancer cells (435/Bcl-x(L)), which overexpress the Bcl-x(L) gene, were labeled with the luciferase gene and injected orthotopically into homozygous athymic Balb/c (nude) mice to study the metastatic behavior of the breast cancer cells. "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Proteins (Proteins, Gene)
3.	docetaxel (Taxotere)
4.	Carbon Monoxide
5.	Messenger RNA (mRNA)
6.	Thymidine Kinase
7.	NF-kappa B (NF-kB)
8.	Antigens
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	beta-Galactosidase (Lactaid)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Transplantation (Transplant Recipients)
4.	Intravenous Injections
5.	Immunotherapy