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Lorazepam (Ativan)

A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.

Also Known As:

Ativan; Temesta; Tolid; AHP Brand of Lorazepam; Apo-Lorazepam; Apotex Brand of Lorazepam; Baxter Brand of Lorazepam; Desitin Brand of Lorazepam; Dolorgiet Brand of Lorazepam; Donix; Duralozam; Durazolam; Idalprem; Laubeel; Llorens Brand of Lorazepam; Lorazepam Medical; Lorazepam-neuraxpharm; Lorazepam-ratiopharm; Medical Brand of Lorazepam; Medix Brand of Lorazepam; Merck dura Brand of Lorazepam; Novartis Brand of Lorazepam; Novo-Lorazem; Novopharm Brand of Lorazepam; Nu-Loraz; Nu-Pharm Brand of Lorazepam; Orfidal Wyeth; Riemser Brand of Lorazepam; Sedicepan; Serra Pamies Brand of Lorazepam; Sinestron; Somagerol; Témesta; WY-4036; Wyeth Brand of Lorazepam; ct-Arzneimittel Brand of Lorazepam; lorazep von ct; neuraxpharm Brand of Lorazepam; ratiopharm Brand of Lorazepam; Apo Lorazepam; ApoLorazepam; Lorazepam AHP Brand; Lorazepam Apotex Brand; Lorazepam Baxter Brand; Lorazepam Desitin Brand; Lorazepam Dolorgiet Brand; Lorazepam Llorens Brand; Lorazepam Medical Brand; Lorazepam Medix Brand; Lorazepam Novartis Brand; Lorazepam Novopharm Brand; Lorazepam Nu-Pharm Brand; Lorazepam Riemser Brand; Lorazepam Wyeth Brand; Lorazepam ct-Arzneimittel Brand; Lorazepam neuraxpharm; Lorazepam neuraxpharm Brand; Lorazepam ratiopharm; Lorazepam ratiopharm Brand; Medical, Lorazepam; Novo Lorazem; NovoLorazem; Nu Loraz; Nu Pharm Brand of Lorazepam; NuLoraz; WY 4036; WY4036; Wyeth, Orfidal; ct Arzneimittel Brand of Lorazepam; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-

Networked: 950 relevant articles (127 outcomes, 153 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Benzazepines: 5
    - Benzodiazepines: 5199
      - Benzodiazepinones
        Lorazepam: 950
        lormetazepam: 40
        Somnium: 1
        3-(4-acetamido)-butyrril-lorazepam
        lopirazepam
        lorazepam acetate
        lorazepam glucuronide
        lorazepam hemisuccinate
        metoclophen-modified nausea suppository
        N-(2-hydroxyethyl)lorazepam

Experts

1.	Huang, Tiao-Lai: 10 articles (11/2013 - 04/2004)
2.	Ely, E Wesley: 8 articles (03/2012 - 01/2004)
3.	Silbergleit, Robert: 6 articles (08/2015 - 10/2011)
4.	Durkalski, Valerie: 5 articles (08/2015 - 10/2011)
5.	Hung, Yi-Yung: 5 articles (01/2013 - 04/2006)
6.	Girard, Timothy D: 5 articles (03/2012 - 01/2007)
7.	Shintani, Ayumi K: 5 articles (03/2012 - 01/2007)
8.	Conwit, Robin: 4 articles (02/2015 - 10/2011)
9.	MacLaren, Robert: 4 articles (05/2014 - 10/2005)
10.	Thompson, Jennifer L: 4 articles (03/2012 - 12/2007)

Related Diseases

1.	Seizures (Seizure) 06/01/1990 - "Our data confirmed clinical reports of lorazepam's effectiveness as a treatment for SE and suggest that a target serum concentration of 200 ng/ml should be effective in most cases and provide seizure protection for 24 hours following treatment." 03/25/1999 - "Treatment with intravenous lorazepam is associated with a significant reduction in the risk of recurrent seizures related to alcohol." 02/01/1984 - "With lorazepam there was a significant reduction in seizures, especially in those with focal and partial complex attacks. " 11/01/2014 - "The efficacy of sublingual Lorazepam for prolonged convulsions beyond sub-saharan Africa: raising more questions than answers." 10/01/1991 - "The diagnosis of seizures and the efficacy of treatment was assessed clinically and by EEG during the administration of lorazepam in three patients and on clinical grounds in four patients. "
2.	Catatonia 04/01/2006 - "Lorazepam is effective in rapidly relieving most cases of catatonia. " 02/01/2005 - "The uses of lorazepam and electroconvulsive therapy (ECT) have been proven to be effective in treating catatonia. " 01/01/2010 - "In this report, we describe two renal-insufficient patients with catatonia who had a good response to intramuscular lorazepam whereby the catatonic symptoms were relieved. " 01/01/2007 - "He was diagnosed with catatonia and was treated successfully with lorazepam. " 08/01/1996 - "Each of the five showed pronounced and rapid improvement after administration of low-dose lorazepam, which has previously been reported to be effective in the treatment of catatonia. "
3.	Vomiting 07/01/2002 - "This article reviews improvements made in antiemetic therapy and considers how the addition of lorazepam may further optimize the prevention and management of emesis at various stages of manifestation." 01/01/1996 - "The incidence of vomiting in the lorazepam group was significantly lower than in the placebo group (14.5% vs 45%). " 06/01/1991 - "Control of vomiting was achieved is 55% (complete 5%, partial 50%) of the patients receiving MCP alone and in 100 percent (complete 76.1%; partial 23.8%) of those receiving MCP plus lorazepam (p less than 0.001). " 07/01/2002 - "An overview of chemotherapy-induced emesis highlighting the role of lorazepam as adjuvant therapy." 12/01/1984 - "Lorazepam for chemotherapy-induced emesis."
4.	Status Epilepticus (Complex Partial Status Epilepticus) 08/01/2009 - "The authors convened concurrent focus groups of research staff and investigators involved in a pharmacokinetic study of lorazepam for status epilepticus (SE). " 01/01/1983 - "Clinical studies of lorazepam in status epilepticus." 09/01/2012 - "There was a wide variability in the management of status epilepticus, and intravenous lorazepam was underutilised." 09/01/2012 - "Status epilepticus occurred on 12 occasions (4.7%) with only three patients receiving lorazepam as treatment. " 04/01/2012 - "To evaluate the single dose pharmacokinetics of an intravenous dose of lorazepam in pediatric patients treated for status epilepticus (SE) or with a history of SE. "
5.	Nausea 01/01/1996 - "Lorazepam reduced the incidence and especially the intensity of nausea. " 04/30/1993 - "However, nausea was shorter in lorazepam arm (p < 0.01), and 80% of the patients preferred treatment with lorazepam (p < 0.003). " 01/01/1991 - "Patients who received lorazepam had, however, significantly fewer nausea episodes during first day post-chemotherapy (p less than 0.05). " 10/01/1994 - "Crossover analysis showed a highly significant effect of lorazepam in reducing the severity of nausea (p = .003); the severity of vomiting was also reduced, but less dramatically (p = .051). " 10/01/1994 - "The frequency of all degrees of nausea and vomiting was less with lorazepam, but the difference was not statistically significant. "

Related Drugs and Biologics

1.	Benzodiazepines
2.	Diazepam (Valium)
3.	Midazolam (Versed)
4.	Metoclopramide (Reglan)
5.	Dexamethasone (Maxidex)
6.	Phenytoin (Dilantin)
7.	Cisplatin (Platino)
8.	Alprazolam (Xanax)
9.	Diphenhydramine (Benadryl)
10.	Phenobarbital (Luminal)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Injections
3.	Premedication
4.	Anesthesia
5.	Intramuscular Injections