Loperamide (Imodium)

One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.

Also Known As:

Networked: 446 relevant articles (65 outcomes, 54 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Riddle, Mark S: 4 articles (07/2014 - 08/2007)
2.	Menéndez, Luis: 4 articles (11/2008 - 05/2003)
3.	Hidalgo, Agustín: 4 articles (11/2008 - 05/2003)
4.	Baamonde, Ana: 4 articles (11/2008 - 05/2003)
5.	Lembo, Anthony J: 3 articles (12/2015 - 07/2006)
6.	DuPont, Herbert L: 3 articles (04/2015 - 05/2007)
7.	Guan, Yun: 3 articles (11/2013 - 08/2008)
8.	Raja, Srinivasa N: 3 articles (11/2013 - 08/2008)
9.	Bashir, Samra: 3 articles (05/2013 - 01/2011)
10.	Araki, Yoko: 3 articles (01/2012 - 01/2010)

Related Diseases

1.	Diarrhea 01/01/2009 - "Best option for traveler's diarrhea: loperamide plus an antibiotic?" 02/01/1996 - "Loperamide was considered the most effective agent for controlling delayed diarrhea. " 03/01/1984 - "Most symptoms improved significantly on placebo compared with the baseline period, but three of these [diarrhea (P less than 0.01), urgency (P less than 0.01) and borborygmi (P less than 0.05)] showed a further significant improvement on loperamide. " 06/01/2005 - "Imodium is more effective than placebo at improving stool consistency and decreasing stool frequency in patients with IBS, and it may be an important component for treating diarrhea-predominant IBS. " 04/01/2013 - "There is a lack of significant studies which investigate the efficacy of loperamide in the symptomatic treatment of diarrhea. "
2.	Constipation 08/01/2013 - "Constipation induced by loperamide in SD rats was improved by administration of PSE. " 03/01/2012 - "This study examined the effects of fig (Ficus carica L.) paste for the treatment of loperamide-induced constipation in a rat model. " 07/20/2010 - "The present study was designed to evaluate the effect of LGP on Cl(-) secretion across rat distal colonic epithelium mounted in Ussing chambers, and on a rat constipation model induced by loperamide, respectively. " 10/01/2015 - "Loperamide was associated with more adverse effects, especially constipation." 01/01/2015 - "plantarum NCU116 enhanced gastrointestinal transit and alleviated in mice with loperamide-induced constipation. "
3.	Pain (Aches) 11/01/2014 - "The study demonstrates that topically applied loperamide encapsulated within liposomal systems has improved therapeutic efficacy over conventional formulations for the local treatment of acute peripheral inflammatory pain conditions where the skin has remained intact. " 05/01/1996 - "Throughout the 5 weeks of treatment an improved stool consistency (32%), reduced defecation frequency (36%), and reduced intensity of pain (30%) were found in the loperamide group. " 07/21/2009 - "Clinical studies have shown that it is just as effective as loperamide in resolving acute diarrhoea but with greater reduction in pain and abdominal distension. " 04/01/2014 - "Loperamide, a potent mu-opioid agonist, has documented analgesic action in various pain conditions. " 04/01/2014 - "Chronic spinal infusion of loperamide alleviates postsurgical pain in rats."
4.	Abdominal Pain (Pain, Abdominal) 01/01/1987 - "In a group with alternating bowel habits and abdominal pain (n = 21) there was also a statistically significant improvement in stool frequency and consistency as well as significantly fewer painful days during loperamide treatment. " 10/01/2003 - "Loperamide is superior to placebo in improvement of diarrhoea but not abdominal pain in IBS. " 07/01/2006 - "Loperamide is ineffective for relief of abdominal pain. " 11/01/2001 - "This patient who had normal rectal emptying had a very high volume tolerability with a maximum tolerable volume of 700 ml. In 4 of 7 patients abdominal pain persisted after the operation, and 3 developed diarrhoea, which required daily intake of loperamide. " 01/01/1987 - "It is concluded that loperamide can be considered an alternative symptomatic treatment in some IBS patients whose main symptoms are painless diarrhoea or alternating bowel habits associated with abdominal pain."
5.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 05/01/1996 - "A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome." 01/01/1987 - "The effect of loperamide was investigated in a double-blind, placebo-controlled study in 60 patients with irritable bowel syndrome (IBS). " 01/01/1987 - "Loperamide in treatment of irritable bowel syndrome--a double-blind placebo controlled study." 03/01/1984 - "Symptom scores, stool data, and the transit of a standard, solid meal were measured in 28 patients with irritable bowel syndrome (IBS) during baseline conditions and after five weeks of treatment with placebo and loperamide, given as a flexible dosage regime in the form of a double-blind, cross-over trial. " 01/01/1987 - "Loperamide treatment of the irritable bowel syndrome."

Related Drugs and Biologics

1.	Ciprofloxacin (Cipro)
2.	Octreotide (Sandostatin)
3.	Loperamide (Imodium)
4.	Azithromycin (Zithromax)
5.	Budesonide (Pulmicort)
6.	Cholestyramine Resin (Questran)
7.	Ofloxacin (Levofloxacin)
8.	bismuth subsalicylate (Pepto-bismol)
9.	acetorphan (ecadotril)
10.	Opioid Receptors (Opioid Receptor)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Analgesia
3.	Enema (Enemas)
4.	Psychology Biofeedback (Biofeedback)
5.	Palliative Care (Palliative Medicine)