Lobeline (Smokeless)

An alkaloid that has actions similar to NICOTINE on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation.

Also Known As:

Networked: 110 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lan, Qing: 7 articles (12/2015 - 11/2008)
2.	Hu, Wei: 5 articles (12/2015 - 01/2012)
3.	Chapman, Robert S: 5 articles (10/2014 - 11/2008)
4.	Li, Jihua: 4 articles (12/2015 - 02/2011)
5.	He, Xingzhou: 4 articles (01/2015 - 11/2008)
6.	Vermeulen, Roel: 4 articles (10/2014 - 02/2009)
7.	Raj, Hans: 4 articles (01/2011 - 10/2004)
8.	Anand, Ashima: 4 articles (01/2011 - 10/2004)
9.	Wei, Fusheng: 3 articles (12/2015 - 03/2012)
10.	Silverman, Debra T: 3 articles (12/2015 - 01/2004)

Related Diseases

1.	Shock 07/01/1993 - "Lobeline (19 mumol/kg, IP) administered immediately after inhibitory (passive) avoidance training improved retention performance assessed 24 h later, as rats that received this dose of lobeline took significantly longer to enter the shock compartment on the test day than rats that had been treated with vehicle. " 05/01/2003 - "Additionally, experimental studies evaluated the analysis of flammable organic solvents, propellants, military explosives, mixtures containing military explosives, shock-sensitive explosives, and gunpowders (i.e., smokeless, black, and Pyrodex powders). "
2.	Cough 05/01/1959 - "[Experimental study, in the chloralosed cat, of the antitussive effects of two synthetic antihistaminics, by means of the pleurotussigenic reflex & lobeline cough]." 01/15/2005 - "These two sets of results show unequivocally that the lobeline-induced cough is evoked reflexly; its magnitude in the conscious state could vary by subjective influences. " 01/15/2005 - "In order to examine, whether the lobeline-induced cough is a true reflex or a voluntary effort to get rid of its irritating sensations in the upper respiratory tract, we systematically studied the cough response to lobeline, of subjects who were unable to make conscious discriminations i.e. " 01/15/2005 - "How does lobeline injected intravenously produce a cough?" 12/01/1998 - "The time (sec) for cough threshold was negatively correlated to threshold dose of lobeline (r = -0.5, and P < 0.05). "
3.	Lung Neoplasms (Lung Cancer) 01/01/2014 - "To characterize HAP exposure related to solid fuel use and ventilation patterns, an exposure assessment study of 163 nonsmoking female heads of households enrolled from 30 villages was conducted in Xuanwei and Fuyuan, two neighboring rural counties with high incidence of lung cancer due to the burning of smoky coal (a bituminous coal, which in health evaluations is usually compared to smokeless coal--an anthracite coal available in some parts of the area). " 01/01/2015 - "Compared with subjects who using smokeless coal or wood, smoky coal use was statistically significantly associated with lung cancer risk (OR=7.7, 95%CI: 4.5-13.3). " 10/01/2014 - "We found lung cancer risk to vary substantially between different coal types, with a higher risk associated with smoky (i.e., bituminous) coal use compared to smokeless (i.e., anthracite) coal use. " 03/01/2012 - "Meanwhile, smokeless coals and wood seemed to have no significant relationship to the lung cancer incidence. " 01/01/2012 - "Compared with smokeless coal, use of smoky coal was associated with an increased risk of lung cancer death (for men, hazard ratio 36 (95% confidence interval 20 to 65); for women, 99 (37 to 266)). "
4.	Neoplasms (Cancer) 06/01/2013 - "Smokeless and dual tobacco use among males surviving childhood cancer: a report from the Childhood Cancer Survivor Study." 01/01/2014 - "Out of only tobacco chewers (smokeless), 83.3% were of oral cavity cancers, 6.7% were of oro- and hypopharynx and the rest were of others. " 06/01/2012 - "The prevalence of tobacco use, both cigarette smoking and smokeless, including iqmik (homemade smokeless tobacco prepared with dried tobacco leaves mixed with alkaline ash), and of tobacco-related cancer is high in Alaskan Native people (AN). " 11/01/1968 - "[Determination of the functional state of the respiratory center by means of the lobeline test in patients with tumors of the posterior cranial fossa]." 12/01/1999 - "tobacco users perceived weight control and reduction of tension as benefits; they accepted warning label as hazardous but reported smokeless not as harmful; they perceived heart disease and cancer as related to tobacco use; and 62% had tried to quit smoking. "
5.	Mouth Neoplasms (Oral Cancer) 01/01/2014 - "There is convincing evidence that smokeless (aka chewing) tobacco, often used as a component of betel quid, and betel quid without tobacco, are both strong and independent risk factors for oral cancer in these populations. " 01/01/2014 - "Assessment of cytogenic damage in the form of micronuclei in oral epithelial cells in patients using smokeless and smoked form of tobacco and non-tobacco users and its relevance for oral cancer." 06/01/2006 - "Reported herein are the results of a structured literature review that was undertaken to (a) determine if human buccal (mouth) cell changes are associated with smoking and smokeless ("chewing") tobacco, (b) tabulate different buccal cell alterations that have been reported, (c) delineate buccal cell assays that have been used successfully, (d) determine whether buccal cell changes correlate with oral cancer as defined in clinicopathologic investigations, and (e) assess the feasibility of developing a high-throughput buccal cell assay for screening smokers for the early detection of oral cancer. " 01/01/1996 - "In areas where tobacco is used in a smokeless form, oral cancer incidence is generally high. " 01/01/1995 - "This review article underscores the compounding but important roles of nutritional/dietary factors in the long-established causal link between abuse of alcohol and tobacco (smoking and smokeless) and oral cancer."

Related Drugs and Biologics

1.	Coal
2.	Codeine (Codeine Phosphate)
3.	Explosive Agents (Explosives)
4.	Solvents
5.	Methamphetamine (Desoxyn)
6.	Hemoglobins (Hemoglobin)
7.	Nicotine
8.	Histamine (Histamine Dihydrochloride)
9.	gamma-Aminobutyric Acid (GABA)
10.	Citric Acid (Citrate)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Self Administration (Administration, Self)
3.	Injections
4.	Intravenous Injections
5.	Transplants (Transplant)