Alcoholic Liver Diseases (Alcoholic Liver Disease)

Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.

Also Known As:

Networked: 2316 relevant articles (48 outcomes, 277 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Fibrosis (Cirrhosis)
2.	Alcoholism (Alcohol Abuse)
3.	Alcoholic Hepatitis
4.	Neoplasms (Cancer)
5.	Hepatitis

Experts

1.	McClain, Craig J: 19 articles (03/2015 - 06/2002)
2.	Petersen, Dennis R: 17 articles (03/2015 - 04/2005)
3.	French, Samuel W: 17 articles (12/2013 - 07/2002)
4.	Szabo, Gyongyi: 16 articles (08/2015 - 09/2005)
5.	Gao, Bin: 16 articles (04/2015 - 01/2002)
6.	Zhou, Zhanxiang: 15 articles (12/2015 - 03/2002)
7.	Song, Zhenyuan: 15 articles (09/2014 - 07/2002)
8.	Lucey, Michael R: 13 articles (05/2014 - 05/2005)
9.	Halsted, Charles H: 13 articles (10/2013 - 01/2002)
10.	Albano, Emanuele: 12 articles (03/2015 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Alcoholic Liver Diseases:

1.	Ethanol (Ethyl Alcohol)IBA 03/01/2013 - "Chronic-binge ethanol feeding leads to high blood alcohol levels; thus, this simple model will be very useful for the study of alcoholic liver disease (ALD) and of other organs damaged by alcohol consumption." 01/01/2015 - "Since oxidative stress is one of the major pathological events during the progression of alcoholic liver diseases, the protective effects and mechanisms of M30 on ethanol-induced hepatocyte injury were investigated in this study. " 05/01/2001 - "Tuma; (2) The formation and clearance of MAA adducts in ethanol-fed rats, by Simon Worrall; (3) Immune responses to MAA adducts may play a role in the development of alcoholic liver disease, by Lynell W. " 05/15/2014 - "Over the last four decades, chronic ethanol feeding studies in rodents using either ad libitum feeding or intragastric infusion models have significantly enhanced our understanding of the pathogenesis of alcoholic liver disease (ALD). " 09/01/2012 - "The present study concluded that BVBF possess potent hepatoprotective effect against ethanol-induced hepatic toxicity and it may have a great potential role in the management of alcoholic liver disease."
2.	PropylthiouracilFDA Link 01/01/2002 - "This systematic review could not demonstrate any significant efficacy of propylthiouracil on any clinically important outcomes (mortality, liver related mortality, liver complications, and liver histology) of patients with alcoholic liver disease and propylthiouracil was associated with adverse events. " 01/01/1991 - "Propylthiouracil shows considerable promise in the out-patient treatment of alcoholic liver disease. " 01/01/2002 - "The objectives were to assess the efficacy of propylthiouracil on mortality, clinical symptoms and complications, liver biochemistry, and liver histology in patients with alcoholic liver disease. " 01/01/2011 - "Accordingly, there is no evidence for using propylthiouracil for alcoholic liver disease outside randomised clinical trials." 01/01/2011 - "Randomised clinical trials have addressed the question whether propylthiouracil has any beneficial effects in patients with alcoholic liver disease. "
3.	SilymarinIBA 01/01/2001 - "Although there were no clinical end-points in the four trials considered in patients with alcoholic liver disease, histological findings were reported as improved in two out of two trials, improvement of prothrombin time was significant (two trials pooled) and liver transaminase levels were consistently lower in the silymarin-treated groups. " 12/01/2014 - "Liverubin™, water soluble active Silymarin, in the popularly prescribed doses of 140-mg tid is observed to be a promising safe and effective drug in cases of alcoholic liver disease. " 12/01/1992 - "It is concluded that in this trial, Silymarin did not change the evolution or mortality of alcoholic liver disease." 12/01/1992 - "A controlled trial on the use of Silymarin in patients with alcoholic liver disease was performed. " 12/01/1992 - "[Controlled study of the effect of silymarin on alcoholic liver disease]."
4.	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 01/01/1976 - "GGTP is very helpful for differentiation and long time observation of alcoholic liver disease, especially with regards controlling abstinence of alcohol." 12/01/1997 - "The sensitivity of gamma-glutamyltransferase which was low in men and women without alcoholic liver disease, improved in groups with moderate or severe alcoholic liver disease: not less than 80% in men and up to 100% in women. " 07/01/2005 - "The present study was designed to establish the role of Gamma-glutamyl transpeptidase (gamma-GT) and mean corpuscular volume (MCV) in alcoholic liver disease (ALD). " 04/01/2013 - "The Serum Gamma Glutamyl Transpeptidase - A Non invasive Diagnostic Bio Marker of Chronic Anicteric Non Alcoholic Liver Diseases." 07/01/2005 - "Utility of gamma-glutamyl transpeptidase and mean corpuscular volume in alcoholic liver disease."
5.	Immunoglobulin A (IgA)IBA 06/01/1988 - "From these studies, the authors conclude that IgA deposition in the liver is not specific for alcoholic liver disease but may reflect the reduced metabolism of damaged liver. " 08/01/1983 - "This study demonstrates a correlation between characteristic IgA deposition in the liver and IgA deposition in and around superficial dermal capillaries in alcoholic liver disease. " 02/01/1982 - "The purpose of this study was to characterize circulating IgA and the IgA deposited in the glomeruli of patients with alcoholic liver disease. " 03/14/2005 - "In alcoholic liver disease with high level of serum IgA, the incidence of the complex was 66.7%, which was higher than that in CH. " 01/01/2003 - "Serum IgA is specifically increased in alcoholic liver disease, which has been considered an IgA-associated disorder. "
6.	IronIBA 02/01/1991 - "Confirmation of the efficacy of hepatic tissue iron index in differentiating genetic haemochromatosis from alcoholic liver disease complicated by alcoholic haemosiderosis." 02/01/1991 - "This study confirms that the hepatic tissue iron index is a useful means of differentiating patients with genetic haemochromatosis from those with alcoholic liver disease. " 09/01/2014 - "Patients with alcoholic liver disease (ALD) often display disturbed iron indices. " 06/01/2013 - "Iron stores assessment in alcoholic liver disease." 09/01/2012 - "Our findings therefore suggest that iron could CPY2E1-independently enhance the oxidative stress induced by alcohol, which probably contributes to the pathogenesis of alcoholic liver disease. "
7.	Aldehyde DehydrogenaseIBA 06/01/2015 - "The present study tested the efficacy of Alda-1, a specific aldehyde dehydrogenase 2 (ALDH2) activator, in treating alcoholic liver disease. " 11/01/2003 - "To study the relationship between aldehyde dehydrogenase (ALDH) gene polymorphism and alcoholic liver disease, and investigate the genetic pathogenesis of alcoholic liver disease (ALD). " 01/01/1989 - "Hepatic lipid peroxidation and aldehyde dehydrogenase activity in alcoholic and non alcoholic liver disease." 03/01/1986 - "Actively drinking alcoholics had significantly lower erythrocyte aldehyde dehydrogenase activity than controls (P less than 0.01) but abstaining alcoholic liver disease and non-alcoholic liver disorder subjects did not. " 03/01/1986 - "Erythrocyte aldehyde dehydrogenase activity was assayed in actively drinking alcoholics, patients with alcoholic liver disease who claimed to be abstaining, patients with non-alcoholic liver disorders and normal controls. "
8.	SteroidsIBA 01/01/2006 - "To assess the beneficial and harmful effects of anabolic-androgenic steroids for patients with alcoholic liver disease based on the results of randomised clinical trials. " 01/01/2006 - "Randomised clinical trials have examined the effects of anabolic-androgenic steroids for alcoholic liver disease. " 01/01/2003 - "The objectives were to assess the beneficial and harmful effects of anabolic-androgenic steroids for patients with alcoholic liver disease based on the results of randomised clinical trials. " 01/01/2003 - "Randomised clinical trials have examined the effects of anabolic-androgenic steroids for alcoholic liver disease. " 01/01/2006 - "This systematic review could not demonstrate any significant beneficial effects of anabolic-androgenic steroids on any clinically important outcomes (mortality, liver-related mortality, liver complications, and histology) of patients with alcoholic liver disease."
9.	S-Adenosylmethionine (Ademetionine)IBA 11/01/2006 - "S-adenosylmethionine (SAM) has emerged as a potential therapeutic for treating alcoholic liver disease through mechanisms that appear to involve decreases in oxidative stress and proinflammatory cytokine production as well as the alleviation of steatosis. " 03/28/2006 - "JNK pathway modulator agents and AdoMet may be components of promising therapies for alcoholic liver disease (ALD) treatment." 10/01/2004 - "These data further support improving the S-adenosylmethionine-to-SAH ratio and removal of intracellular SAH as potential therapeutic options in alcoholic liver disease." 07/01/2002 - "Hepatic deficiency of S-adenosylmethionine (AdoMet) is a critical acquired metabolic abnormality in alcoholic liver disease (ALD) and in many experimental models of hepatotoxicity. " 11/01/2000 - "Role of S-adenosylmethionine in hyperhomocysteinemia and in the treatment of alcoholic liver disease."
10.	Carbon MonoxideIBA 06/01/2006 - "co-cultures) are being used with promising results that advance our understanding of alcoholic liver disease." 12/01/2005 - " alcohol misuse, alcoholic liver disease, and the co-existence of other pathologies such as ischemic heart disease were frequently contributory factors. " 04/01/2002 - "This suggests that, through steatosis, insulin resistance could be a co-factor of alcoholic liver disease. " 04/01/1999 - "Secondly, it shows the rare co-existence of alcoholic liver disease and vasculitis." 02/01/2014 - "EXCLUSION CRITERIA WERE AS FOLLOWS: decompensated liver disease, alcoholic liver disease or alcohol intake of 40 g or more per week; co-infection with human immunodeficiency virus, hepatitis C virus, or hepatitis D virus. "

Therapies and Procedures

1.	Liver Transplantation 11/01/2006 - "Efficacy of 6-month pretransplant abstinence for patients with alcoholic liver disease undergoing living donor liver transplantation." 02/01/2016 - "Predictors of heavy drinking after liver transplantation for alcoholic liver disease in Denmark (1990-2013): a nationwide study with competing risks analyses." 10/01/2014 - "Although up to 50% of patients with alcoholic liver disease (ALD) resume alcohol consumption after liver transplantation (LT), numerous studies indicate that long-term results are not compromised. " 04/01/2014 - "Because most liver transplantation (LT) studies for alcoholic liver disease (ALD) were performed on deceased donor LT, little was still known following living donor LT (LDLT). " 01/01/2011 - "Mental health and quality of life in alcoholic liver disease patients after liver transplantation: a prospective controlled study."
2.	Transplantation (Transplant Recipients) 05/01/2002 - "The incidence of de novo malignancy was significantly greater in patients who underwent transplantation for alcoholic liver disease compared with other groups (P <.001). " 05/01/2001 - "Of 64 patients who underwent transplantation for alcoholic liver disease (ALD) between May 1996 and November 1999, a total of 49 surviving patients (40 men, 9 women) were available for study. " 10/01/2015 - "Recidivism in Liver Transplant Recipients With Alcoholic Liver Disease: Analysis of Demographic, Psychosocial, and Histology Features." 04/01/2015 - "Alcoholic liver disease was associated with anxiety and depression in the short term after transplantation. " 07/07/2014 - "Challenges in transplantation for alcoholic liver disease."
3.	Transplants (Transplant) 01/01/2010 - "As graft challenge due to recurrent underlying disease can best be eliminated and controlled in patients transplanted for alcoholic liver disease (ALD) we analysed liver biopsies of ALD patients during a 10-year follow-up with special emphasis on donor age and parenchymal quality. " 10/01/2013 - "This study suggests that it may not be beneficial to wait for more definitive treatment, like liver transplant in alcoholic liver disease patients, since the liver tissue remained largely with the same degree of pathology six months out, regardless of treatment." 05/01/2003 - "The present study indicates that patients can resume heavy alcohol consumption after LT for alcoholic liver disease (ALD) and their grafts can be injured because of poor compliance with immunosuppressive drugs and alcohol-related liver injury. " 10/01/2015 - "Demographic, psychosocial, and histology features were evaluated as risk factors toward harmful recidivism in 148 recipients of liver transplant with alcoholic liver disease. " 10/01/2015 - "We sought to identify risk factors for recidivism and survival in recipients of liver transplant with alcoholic liver disease. "
4.	Oral Administration 04/01/2015 - "Future clinical trials may demonstrate that oral administration of DEC may be suitable for the treatment of alcoholic liver disease and other liver diseases." 12/10/2008 - "Oral administration of heat-killed Lactobacillus brevis SBC8803 ameliorates alcoholic liver disease in ethanol-containing diet-fed C57BL/6N mice." 07/01/1998 - "These observations suggest that oral administration of a low-carbohydrate liquid ethanol diet may provide an affordable alternative to the technically demanding intragastric feeding model for experimental studies of alcoholic liver disease." 07/01/1982 - "In patients with alcoholic liver disease the elimination half-life after oral administration of two 250-mg enteric-coated tablets was 3.2 +/- 0.5 hours, significantly different from that in normal subjects, probably due to impaired metabolism. " 01/01/1989 - "4. In spite of the changes detected in subjects with alcoholic liver disease, curves of blood ethanol concentration after oral administration of 0.4 g of ethanol/kg were indistinguishable between the alcoholic hepatitis group and the control group. "
5.	Sclerotherapy 04/30/1992 - "[Preventive sclerotherapy in alcoholic liver diseases and esophageal varices]." 06/20/1991 - "For unknown reasons, prophylactic sclerotherapy is associated with increased mortality among men with moderate-to-severe alcoholic liver disease and esophageal varices. " 06/20/1991 - "Prophylactic sclerotherapy for esophageal varices in men with alcoholic liver disease. " 06/20/1991 - "Sclerotherapy is an effective treatment for bleeding esophageal varices in patients with alcoholic liver disease. " 06/20/1991 - "We conducted a prospective, randomized trial comparing prophylactic sclerotherapy and sham therapy in 281 men with alcoholic liver disease who had at least three variceal channels and no history of variceal bleeding. "